Psychological Aspects of Chronic Pelvic Pain in Women With Endometriosis

Jacob, Mary Casey

doi:10.1007/978-1-4613-8404-5_27

Cited by 4 publications

(3 citation statements)

References 44 publications

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“…54 All in all, because each condition individually has a strong impact on pelvic pain, 41,61,123 the quality of life of patients with both conditions, or with CPP, is consequently markedly reduced. 17,117,121,128 Encouraging reports of progress towards new therapies based on preclinical research are tempered by relatively low success rates in subsequent clinical trials. A major factor for this discrepancy may relate to reproducibility, reliability, and robustness of the animal models used and whether they adequately reflect the full spectrum of symptoms and disease pathophysiology in patients, 50 especially regarding pain.…”

Section: Introductionmentioning

confidence: 99%

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Preclinical models of endometriosis and interstitial cystitis/bladder pain syndrome: an Innovative Medicines Initiative-PainCare initiative to improve their value for translational research in pelvic pain

Nunez-Badinez

Leo

Laux-Biehlmann

et al. 2021

Pain

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Endometriosis (ENDO) and interstitial cystitis/bladder pain syndrome (IC/BPS) are chronic pain conditions for which better treatments are urgently needed. Development of new therapies with proven clinical benefit has been slow. We have conducted a review of existing preclinical in vivo models for ENDO and IC/BPS in rodents, discussed to what extent they replicate the phenotype and pain experience of patients, as well as their relevance for translational research. In 1009 publications detailing ENDO models, 41% used autologous, 26% syngeneic, 18% xenograft, and 11% allogeneic tissue in transplantation models. Intraperitoneal injection of endometrial tissue was the subcategory with the highest construct validity score for translational research. From 1055 IC/BPS publications, most interventions were bladder centric (85%), followed by complex mechanisms (8%) and stress-induced models (7%). Within these categories, the most frequently used models were instillation of irritants (92%), autoimmune (43%), and water avoidance stress (39%), respectively. Notably, although pelvic pain is a hallmark of both conditions and a key endpoint for development of novel therapies, only a small proportion of the studies (models of ENDO: 0.5%-12% and models of IC/BPS: 20%-44%) examined endpoints associated with pain. Moreover, only 2% and 3% of publications using models of ENDO and IC/BPS investigated nonevoked pain endpoints. This analysis highlights the wide variety of models used, limiting reproducibility and translation of results. We recommend refining models so that they better reflect clinical reality, sharing protocols, and using standardized endpoints to improve reproducibility. We are addressing this in our project Innovative Medicines Initiative-PainCare/Translational Research in Pelvic Pain.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preclinical models of endometriosis and interstitial cystitis/bladder pain syndrome: an Innovative Medicines Initiative-PainCare initiative to improve their value for translational research in pelvic pain

Nunez-Badinez

Leo

Laux-Biehlmann

et al. 2021

Pain

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“…Often, sociocultural factors play a role as well: women tend to trivialize menstrual pain because they often face lack of understanding within their families (familial clustering). 7 – 9 The gold standard for a conclusive diagnosis is invasive laparoscopy with biopsy.…”

Section: Introductionmentioning

confidence: 99%

CYFRA 21-1 in urine: a diagnostic marker for endometriosis?

Gjavotchanoff¹

2015

IJWH

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Diagnostic workup of endometriosis usually involves laparoscopic inspection and histological examination of biopsies. Unequivocal laboratory parameters for this ailment have not been available in routine diagnostic evaluations thus far. In this study, we examined urine concentrations of cytokeratin 19 (CYFRA 21-1), a structural protein specific for epithelia. We performed immunoassays for CYFRA 21-1 in urine samples from women afflicted with endometriosis throughout their menstrual cycle. We observed a significant increase in CYFRA 21-1 concentrations, corrected by creatinine levels, in the late follicular phase as compared with the level in healthy controls. We conclude that cyclically increased CYFRA 21-1 concentrations in urine could serve as a valuable noninvasive diagnostic parameter in the workup of clinically manifesting endometriosis.

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The Role of the Mental Health Professional in the Management of Chronic Pelvic Pain

Greenfeld¹,

Jacob²

1998

Chronic Pelvic Pain

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Psychological Aspects of Chronic Pelvic Pain in Women With Endometriosis

Cited by 4 publications

References 44 publications

Preclinical models of endometriosis and interstitial cystitis/bladder pain syndrome: an Innovative Medicines Initiative-PainCare initiative to improve their value for translational research in pelvic pain

Preclinical models of endometriosis and interstitial cystitis/bladder pain syndrome: an Innovative Medicines Initiative-PainCare initiative to improve their value for translational research in pelvic pain

CYFRA 21-1 in urine: a diagnostic marker for endometriosis?

The Role of the Mental Health Professional in the Management of Chronic Pelvic Pain

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Psychological Aspects of Chronic Pelvic Pain in Women With Endometriosis

Cited by 4 publications

References 44 publications

Preclinical models of endometriosis and interstitial cystitis/bladder pain syndrome: an Innovative Medicines Initiative-PainCare initiative to improve their value for translational research in pelvic pain

Preclinical models of endometriosis and interstitial cystitis/bladder pain syndrome: an Innovative Medicines Initiative-PainCare initiative to improve their value for translational research in pelvic pain

CYFRA 21-1 in urine: a diagnostic marker for&nbsp;endometriosis?

The Role of the Mental Health Professional in the Management of Chronic Pelvic Pain

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CYFRA 21-1 in urine: a diagnostic marker for endometriosis?