Psychological Burden and Gender Differences in Methamphetamine-Dependent Individuals in Treatment

Simpson, Jamie L.; Grant, Kathleen M.; Daly, Patrick M.; Kelley, Stephanie; Carlo, Gustavo; Bevins, Rick A.

doi:10.1080/02791072.2016.1213470

Cited by 46 publications

(41 citation statements)

References 40 publications

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“…This is consistent with a study from Iran, which indicated that female methadone patients experienced side effects because of MA dependence (8). A study from the US indicated that MA-dependent females showed adverse health impacts of MA use (12).…”

Section: Discussionsupporting

confidence: 90%

Methamphetamine Dependence Among Iranian Female Methadone Patients: A Cross-Sectional Survey of Three Cities of Iran

Tavakoli¹,

Effatpanah

Moradi

et al. 2018

Iran J Psychiatry Behav Sci

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Background: Methamphetamine (MA) dependence is a health concern in Iran (Persia). One main impacted group is female methadone patients. Objectives: The aim of this paper was to briefly report the prevalence of MA dependence among female methadone patients in 3 large cities of Iran. The other aim was to report the status of psychological well-being and social functioning among MA-dependent and non-MA dependent participants. Methods: In the first survey of Iran, 570 females were recruited from 38 main methadone clinics in Mashhad, Karaj, and Isfahan. A researcher-designed questionnaire was used to collect baseline demographics, details of MA use, and treatment history. Results: Of them, 266 females were MA-dependent. In other words, the prevalence of MA dependence among females was 46.6%. The length of MA dependence was 5 years. The adverse health impacts of high doses of methadone use were the main self-reported reasons for MA dependence. These adverse health impacts included depression (n = 118, 44.36%), oversleeping (n = 88, 33.08%), and low physical energy to do the housework (n = 60, 22.55%). However, lifetime MA treatment was only 25%. The prevalence of MA dependence was significantly associated with poor psychological well-being (P < 0.01) and social dysfunction (P < 0.01) among MA dependent females compared with non-MA dependent females. Conclusions: Methamphetamine dependence was common and associated with serious health problems. Special treatment services should be provided for these females.

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Section: Discussionsupporting

confidence: 90%

Methamphetamine Dependence Among Iranian Female Methadone Patients: A Cross-Sectional Survey of Three Cities of Iran

Tavakoli¹,

Effatpanah

Moradi

et al. 2018

Iran J Psychiatry Behav Sci

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“…This issue demands an effective treatment. Comorbidities, such as poor mental health, can reduce positive drug treatment outcomes (14). Further studies are suggested in this regard.…”

Section: Discussionmentioning

confidence: 99%

Methamphetamine Dependence, Psychological Well-being, Criminality and High Risk Sexual Behaviors in Female-Only Methadone Services in Tehran and Karaj, Iran

Massah

Shishehgar

2018

Iran J Psychiatry Behav Sci

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Background: Methamphetamine (MA) abuse is a health concern among drug abuse patients in Iran. Objectives: This study aimed at determining the prevalence of MA dependence among a group of female methadone users and investigating the current psychological well-being, high risk sexual and criminality behaviors, and the status of receiving MA treatment. Methods: This study was a cross-sectional survey conducted in Iran. The study was conducted at 5 central female-only methadone services in Tehran and Karaj, during years 2011 to 2013. A questionnaire was devised to collect baseline data. The general health questionnaire-28 and the Opiate Treatment Index were used to assess psychological well-being, and criminality and high-risk sexual behaviors. Results: Overall, 245 females were registered at these sites. Of them, 201 females (82%) were dependent on MA while on treatment. Duration of MA dependence was 6 years. However, only 14.3% of the participants reported lifetime MA treatment. No participant was on MA treatment. Participants reported high rates of MA-related depression (76.4%), anxiety (68.4%), social dysfunction (41.2%), and somatic symptoms (38.2%), respectively. Untreated MA dependence in methadone treatment was associated with engagement in high-risk sexual behaviors (43.8%) and criminality (28.7%). Only 10% of the participants reported receiving a lifetime matrix model. All of them reported that the Matrix model was long and it was not easily available in methadone services. Conclusions:The study showed that the high prevalence for MA dependence and its adverse health impacts while receiving MA treatment remained the same. Effective psychosocial treatments should be delivered for MA dependence among female methadone users.

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“…Increased rates of depression, psychosis, and suicide have also been reported in females compared to males (Glasner-Edwards et al, 2008AB; Mahoney et al, 2010). Female METH users also reported a greater severity of drug use and psychological burden than their male counterpart (Simpson et al, 2016), further demonstrating the importance of investigating gender differences in METH users.…”

Section: 0 Introductionmentioning

confidence: 99%

The neurochemical consequences of methamphetamine self-administration in male and female rats

Johansen

McFadden

2017

Drug and Alcohol Dependence

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Background Methamphetamine (METH) is an addictive substance that is used in both males and females. Few preclinical studies have focused on understanding sex-differences in the neurochemical consequences of contingent METH. The purpose of the current study was to investigate potential sex-differences in the neurochemical consequences of METH self-administration. Methods Male and female adult rats were given extended access to METH or saline self-administration for 7 d. Following self-administration, hippocampal brain-derived neurotrophic factor (BDNF) and striatal dopamine transporter (DAT) were assessed via western blotting. Results Male and female rats had similar METH intake. METH self-administration reduced striatal DAT in both sexes, but only males that self-administered METH had elevated hippocampal BDNF levels. Conclusions Sex-differences exist in the neurochemical consequences of METH self-administration. These differences may lead to sex-specific vulnerability to the toxic effects of METH.

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Psychological Burden and Gender Differences in Methamphetamine-Dependent Individuals in Treatment

Abstract: Overall, this study suggests that, unlike many other illicit drugs, severity of use and problems associated with use were not elevated in METH-dependent men compared to women. In fact, several factors indicated more severe patterns of use or risk factors in women.

Cited by 46 publications

References 40 publications

Methamphetamine Dependence Among Iranian Female Methadone Patients: A Cross-Sectional Survey of Three Cities of Iran

Methamphetamine Dependence Among Iranian Female Methadone Patients: A Cross-Sectional Survey of Three Cities of Iran

Methamphetamine Dependence, Psychological Well-being, Criminality and High Risk Sexual Behaviors in Female-Only Methadone Services in Tehran and Karaj, Iran

The neurochemical consequences of methamphetamine self-administration in male and female rats

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