Psychological Correlates of Survival on Renal Dialysis

Ziarnik, Jon P.; Freeman, Charles W.; Sherrard, Donald J.; Calsyn, Donald A.

doi:10.1097/00005053-197703000-00007

Cited by 44 publications

(21 citation statements)

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“…Depression was also associated with mortality (30,31) and morbidity (21) in patients living with different transplanted organs. Most of the studies analyzing this question in dialysis patients also confirmed that depression was associated with negative outcome both in hemodialysis and peritoneal dialysis patients (1,6,(32)(33)(34)(35)(36)(37).…”

Section: Discussionmentioning

confidence: 89%

Depressive Symptoms and Mortality in Patients After Kidney Transplantation: A Prospective Prevalent Cohort Study

Novák

Molnar

Szeifert

et al. 2010

Psychosomatic Medicine

110

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Section: Discussionmentioning

confidence: 89%

Depressive Symptoms and Mortality in Patients After Kidney Transplantation: A Prospective Prevalent Cohort Study

Novák

Molnar

Szeifert

et al. 2010

Psychosomatic Medicine

110

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“…Clinical depression and subthreshold depressive symptoms are associated with increased mortality rates in dialysis patients (1)(2)(3)(4)(5)(6)(7)(8) and after kidney transplantation (9). However, little is known about the longitudinal association between elevated depressive symptoms with a decline in kidney function, subsequent new-onset (incident) stage 3 to 4 CKD, or clinical renal outcomes such as ESRD and acute kidney injury (AKI) in individuals who are not yet on dialysis (10,11).…”

Section: Introductionmentioning

confidence: 99%

“…In dialysis patients, the prevalence of depression is high, ranging from 20 to 35% (1)(2)(3)(4)(5)(6)(7)(8)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21), which in part reflects a psychologic response to substantial disease burden. Studying depressive symptoms in individuals at risk for CKD provides unique opportunities to identify early risk factors for renal disease progression that cannot be achieved by studying dialysis patients (10).…”

Section: Introductionmentioning

confidence: 99%

Longitudinal Association of Depressive Symptoms with Rapid Kidney Function Decline and Adverse Clinical Renal Disease Outcomes

Kop¹,

Seliger²,

Fink³

et al. 2011

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives Depression is a risk indicator for adverse outcomes in dialysis patients, but its prognostic impact in individuals who are not yet on dialysis is unknown. This study examines whether depressive symptoms are longitudinally associated with renal function decline, new-onset chronic kidney disease (CKD), ESRD, or hospitalization with acute kidney injury (AKI).Design, setting, participants, & measurements Depressive symptoms were measured in a longitudinal cohort study with the 10-item Centers for Epidemiologic Studies Depression scale using a previously validated cut-off value (Ն8). CKD at study entry and during follow-up was defined as an estimated GFR (eGFR) Ͻ 60 ml/min per m 2 . Outcomes were rapid decline in eGFR (Ͼ3 ml/min per m 2 per year), new-onset CKD, ESRD (U.S. Renal Data System-based), and AKI (based on adjudicated medical record review). The median follow-up duration was 10.5 years.Results Depressed participants (21.2%) showed a higher prevalence of CKD at baseline compared with nondepressed participants in multivariable analysis. Depression was associated with a subsequent risk of rapid decline in eGFR, incident ESRD, and AKI, but not incident CKD in unadjusted models. In multivariable analyses, only associations of depressive symptoms with AKI remained significant.Conclusions Elevated depressive symptoms are associated with subsequent adverse renal disease outcomes. The depression-related elevated risk of AKI was independent of traditional renal disease risk factors and may in part be explained by the predictive value of depression for acute coronary syndromes and heart failure hospitalizations that can be complicated by AKI.

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“…Many previous studies considered depression as an important factor that determines the patient's survival (12)(13)(14)(15), but they did not succeed in measuring or controlling physiological factors that can reflect the severity of disease.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Depression in Continuous Ambulatory Peritoneal Dialysis Patients

et al. 2002

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It is well known that depression and sense of hopelessness worsen the quality of life in end-stage renal disease (ESRD) patients receiving dialysis. However, the characteristics of depression in continuous ambulatory peritoneal dialysis (CAPD) patients have not been analyzed in detail. We performed this study to investigate the severity of depression and the factors affecting depression in CAPD patients. With 96 CAPD patients, we evaluated each patient's depressive mood and hopelessness with CES-D (Center for Epidemiologic Studies Depression) scale and Beck Hopelessness Scale. We also evaluated the degree of stress of each patient with internal individual stress scale. Most CAPD patients experienced severe depression compared with the general population. Their depression was better explained by psychological factors, such as stress and sense of hopelessness, than by demographic or physical factors. On the basis of these findings, we suggest that the treatment of depression in CAPD patients might be possible by modulation of psychological factors.

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Psychological Correlates of Survival on Renal Dialysis

Cited by 44 publications

References 0 publications

Depressive Symptoms and Mortality in Patients After Kidney Transplantation: A Prospective Prevalent Cohort Study

Depressive Symptoms and Mortality in Patients After Kidney Transplantation: A Prospective Prevalent Cohort Study

Longitudinal Association of Depressive Symptoms with Rapid Kidney Function Decline and Adverse Clinical Renal Disease Outcomes

Analysis of Depression in Continuous Ambulatory Peritoneal Dialysis Patients

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