Psychological disorders in rheumatoid arthritis: a growing consensus?

Creed, Francis

doi:10.1136/ard.49.10.808

Cited by 112 publications

(65 citation statements)

References 36 publications

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“…Anxiety and depressive disorders occur in 20-25% of patients with RA. 205 In contrast with an increased incidence of MDD in RA, a decreased risk of schizophrenia has been reported in patients with RA. 206 The development of psychiatric symptoms in patients with RA may be, at least in part, the result of chronic physical symptoms such as pain and disability.…”

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confidence: 99%

Brain-immune interactions and disease susceptibility

2005

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Many studies have established the routes by which the immune and central nervous (CNS) systems communicate. This network of connections permits the CNS to regulate the immune system through both neuroendocrine and neuronal pathways. In turn, the immune system signals the CNS through neuronal and humoral routes, via immune mediators and cytokines. This regulatory system between the immune system and CNS plays an important role in susceptibility and resistance to autoimmune, inflammatory, infectious and allergic diseases. This review focuses on the regulation of the immune system via the neuroendocrine system, and underlines the link between neuroendocrine dysregulation and development of major depressive disorders, autoimmune diseases and osteoporosis.

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confidence: 99%

Brain-immune interactions and disease susceptibility

2005

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“…Psychologic distress was measured using the Symptom Checklist 90 Revised (SCL-90-R) (16), a widely used and well-validated 90-item self-report symptom inventory that reflects the psychologic symptom patterns of psychiatric and medical patients. Nine primary symptom dimensions are assessed: 1) somatization, 2) obsessive-compulsive, 3) interpersonal sensitivity, 4) depression, 5) anxiety, 6) hostility, 7) phobic anxiety, 8) paranoid ideation, and 9) psychoticism. Given that the SCL-90-R does not yield psychiatric diagnoses as such, it is important to clarify what these scales mean.…”

Section: Subjectsmentioning

confidence: 99%

Psychosocial contributors to mental and physical health in patients with systemic lupus erythematosus

Dobkin

Fortin

Joseph

et al. 1998

Arthritis & Rheumatism

101

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“…7 The prevalence of depression among individuals with arthritis can be very high, ranging from 17 to 27 %, depending on the type of arthritis and definition of depression. [9][10][11][12] It has been estimated that among adults in the age group of 54-65 years, 18.1 % of major depression is attributable to arthritis. 10 A greater proportion of individuals with osteoarthritis are reported to have depression (12.4 %) as compared to individuals without osteoarthritis.…”

Section: Introductionmentioning

confidence: 99%

Healthcare Expenditures Associated with Depression Among Individuals with Osteoarthritis: Post-Regression Linear Decomposition Approach

Agarwal

Sambamoorthi

2015

J GEN INTERN MED

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BACKGROUND: Depression is common among individuals with osteoarthritis and leads to increased healthcare burden. The objective of this study was to examine excess total healthcare expenditures associated with depression among individuals with osteoarthritis in the US. DESIGN: Adults with self-reported osteoarthritis (n= 1881) were identified using data from the 2010 Medical Expenditure Panel Survey (MEPS). Among those with osteoarthritis, chi-square tests and ordinary least square regressions (OLS) were used to examine differences in healthcare expenditures between those with and without depression. Post-regression linear decomposition technique was used to estimate the relative contribution of different constructs of the Anderson's behavioral model, i.e., predisposing, enabling, need, personal healthcare practices, and external environment factors, to the excess expenditures associated with depression among individuals with osteoarthritis. All analysis accounted for the complex survey design of MEPS. KEY RESULTS: Depression coexisted among 20.6 % of adults with osteoarthritis. The average total healthcare expenditures were $13,684 among adults with depression compared to $9284 among those without depression. Multivariable OLS regression revealed that adults with depression had 38.8 % higher healthcare expenditures (p<0.001) compared to those without depression. Postregression linear decomposition analysis indicated that 50 % of differences in expenditures among adults with and without depression can be explained by differences in need factors. CONCLUSIONS: Among individuals with coexisting osteoarthritis and depression, excess healthcare expenditures associated with depression were mainly due to comorbid anxiety, chronic conditions and poor health status. These expenditures may potentially be reduced by providing timely intervention for need factors or by providing care under a collaborative care model.

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Psychological disorders in rheumatoid arthritis: a growing consensus?

Cited by 112 publications

References 36 publications

Brain-immune interactions and disease susceptibility

Brain-immune interactions and disease susceptibility

Psychosocial contributors to mental and physical health in patients with systemic lupus erythematosus

Healthcare Expenditures Associated with Depression Among Individuals with Osteoarthritis: Post-Regression Linear Decomposition Approach

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