Psychological distress in breast cancer patients during oncological inpatient rehabilitation: incidence, triggering factors and correlation with treatment-induced side effects

Hass, Holger G.; Seywald, M; Wöckel, Achim; Muco, Blerta; Tanriverdi, Miro; Stepien, Jürgen

doi:10.1007/s00404-022-06657-3

Cited by 10 publications

(8 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast to the study of women with BC already cited, mental distress and sleep disorders were less pronounced in the collective of men with MBC (47.0 vs. 60.4% and 37.2 vs. 51.9%) possibly due to the significantly higher patient age of the men (62.0 ± 10.6 vs. 55.7 ± 10.4 years). A significant correlation between younger age and higher distress levels in women with BC was recently reported by other research groups and our team [19][20][21].…”

Section: Discussionsupporting

confidence: 80%

Male Breast Cancer: Therapy-Induced Toxicities, Psychological Distress, and Individual Patient Goals during Oncological Inpatient Rehabilitation

Hass¹,

Herzberger²,

Wöckel³

et al. 2022

Oncol Res Treat

View full text Add to dashboard Cite

Introduction. Male breast cancer (MBC) is a rare malignancy that accounts for less than 1% of all cancers in men and less than 1% of all breast cancers worldwide. Understandably, due to the low incidence of this rare cancer there is a lack of prospective clinical data. Aim of this retrospective study was the analysis of therapy-induced toxicities as well as the assessment of psychological distress in the affected men during oncological inpatient rehabilitation. Methods. 51 MBC patients were evaluated for presence of treatment-induced side effects, toxicities and psychological distress (using German version of the 11-stage NCCN distress thermometer; cut-off ≥5) during oncological indoor rehabilitation. The collected data was checked for correlation with socio-demographic and clinical factors (SPSS 22). Results. The mean age was 62.0 ± 10.6 years, in 96% a hormone-dependent breast tumor (ER+) and in over 75% overweigt or obesity (BMI > 25/>30) was diagnosed. Most reported side effects included weakness/fatigue (74.5%), arthralgia after surgery/chemotherapy (43.1%), chemotherapy-induced polyneuropathy (CIPN; 36.3%) and/or lymphedema (13.7%). Psychological distress was detected in 24 cases (47.0%; ≥5), in 13 cases even with significantly high levels (25.5%; ≥7). There was no correlation between psychological distress and clinical factors such as age, performed treatment (e.g. chemotherapy) or therapy-induced side effects (e.g. lymphedema) in our small collective. Conclusions. Psychological distress and somatic side effects are common in MBC. These data demonstrate the importance of routine screening for psychological distress and the high need for psycho-oncological therapy (regardless of gender) in multimodal oncological rehabilitation.

show abstract

Section: Discussionsupporting

confidence: 80%

Male Breast Cancer: Therapy-Induced Toxicities, Psychological Distress, and Individual Patient Goals during Oncological Inpatient Rehabilitation

Hass¹,

Herzberger²,

Wöckel³

et al. 2022

Oncol Res Treat

View full text Add to dashboard Cite

show abstract

“…TNBC is also often associated with genetic factors, which can further increase the burden. Overall, the psychological impact of TNBC can be significant, requiring specialized support and care to address the emotional and mental well-being of patients facing this challenging form of breast cancer ( 7 , 32 – 34 ).…”

Section: Discussionmentioning

confidence: 99%

App-based support for breast cancer patients to reduce psychological distress during therapy and survivorship – a multicentric randomized controlled trial

Wolff,

Seidel,

Wuelfing

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

IntroductionThe negative impact of unmanaged psychological distress on quality of life and outcome in breast cancer survivors has been demonstrated. Fortunately, studies indicate that distress can effectively be addressed and even prevented using evidence-based interventions. In Germany prescription-based mobile health apps, known as DiGAs (digital health applications), that are fully reimbursed by health insurances, were introduced in 2020. In this study, the effectiveness of an approved breast cancer DiGA was investigated: The personalized coaching app PINK! Coach supports and accompanies breast cancer patients during therapy and follow-up.MethodsPINK! Coach was specifically designed for breast cancer (BC) patients from the day of diagnosis to the time of Follow-up (aftercare). The app offers individualized, evidence-based therapy and side-effect management, mindfulness-based stress reduction, nutritional and psychological education, physical activity tracking, and motivational exercises to implement lifestyle changes sustainably in daily routine. A prospective, intraindividual RCT (DRKS00028699) was performed with n = 434 patients recruited in 7 German breast cancer centers from September 2022 until January 2023. Patients with BC were included independent of their stage of diseases, type of therapy and molecular characteristics of the tumor. Patients were randomized into one of two groups: The intervention group got access to PINK! over 12 weeks; the control group served as a waiting-list comparison to “standard of care.” The primary endpoint was psychological distress objectified by means of Patient Health Questionnaire-9 (PHQ-9). Subgroups were defined to investigate the app’s effect on several patient groups such as MBC vs. EBC patients, patients on therapy vs. in aftercare, patients who received a chemotherapy vs. patients who did not.ResultsEfficacy analysis of the primary endpoint revealed a significant reduction in psychological distress (least squares estimate -1.62, 95% confidence interval [1.03; 2.21]; p<0.001) among intervention group patients from baseline to T3 vs, control group. Subgroup analysis also suggested improvements across all clinical situations.ConclusionPatients with breast cancer suffer from psychological problems including anxiety and depression during and after therapy. Personalized, supportive care with the app PINK! Coach turned out as a promising opportunity to significantly improve psychological distress in a convenient, accessible, and low-threshold manner for breast cancer patients independent of their stage of disease (EBC/MBC), therapy phase (aftercare or therapy) or therapy itself (chemotherapy/other therapy options). The app is routinely available in Germany as a DiGA. Clinical Trial Registration: DRKS Trial Registry (DRKS00028699).

show abstract

“…Da die Inzidenz psychischer Komorbiditäten in der Onkologie nach aktueller Datenlage mit jüngerem Alter und weiblichem Geschlecht korreliert, sind insbesondere Brustkrebs-Patientinnen häufig betroffen [19,20].…”

Section: Lungentoxizitäten Unter Der Therapie Mit Antikörper-drug-kon...unclassified

“…Diese therapeutischen Erfolge werden jedoch teils mit vielfältigen Nebenwirkungen und Toxizitäten im somatischen sowie psychovegetativen Bereich erkauft ( Abb. 1 ) 3 . So berichten die Patientinnen neben den typischen Nebenwirkungen einer systemischen Chemotherapie (Alopezie, Diarrhö-Neigung, Blutbildveränderungen, Hauttoxizitäten etc.)…”

Section: Einleitung – Moderne Multimodale Therapie Des Mammakarzinomsunclassified

Onkologische Rehabilitation bei Mammakarzinom

Hass

2024

Rehabilitation (Stuttg)

Self Cite

View full text Add to dashboard Cite

Die Prognose des Mammakarzinoms hat sich durch eine zunehmend individualisierte Therapie deutlich verbessert. Allerdings kann es infolge der multimodalen Behandlung und dem Einsatz neuer Medikamente zu einer Vielzahl von somatischen und psychischen Folgestörungen kommen. Nachfolgend werden typische sowie neue Therapie-induzierte Nebenwirkungen erörtert und die zur Rehabilitation notwendigen Maßnahmen vorgestellt.

show abstract

Psychological distress in breast cancer patients during oncological inpatient rehabilitation: incidence, triggering factors and correlation with treatment-induced side effects

Cited by 10 publications

References 22 publications

Male Breast Cancer: Therapy-Induced Toxicities, Psychological Distress, and Individual Patient Goals during Oncological Inpatient Rehabilitation

Male Breast Cancer: Therapy-Induced Toxicities, Psychological Distress, and Individual Patient Goals during Oncological Inpatient Rehabilitation

App-based support for breast cancer patients to reduce psychological distress during therapy and survivorship – a multicentric randomized controlled trial

Onkologische Rehabilitation bei Mammakarzinom

Contact Info

Product

Resources

About