Psychological health in patients with genital and oral erosive lichen planus

Lundqvist, Elisabet Nylander; Wahlin, Ylva-Britt; Bergdahl, Maud; Bergdahl, Jan

doi:10.1111/j.1468-3083.2006.01559.x

Cited by 83 publications

(85 citation statements)

References 17 publications

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“…(11) Sunulan araştırmada da anksiyete düzeyinin OLP'lu hastalarda istatistiksel olarak yüksek olduğu saptanmıştır. Ancak Lundvist ve arkadaşlarının (14) araştırmalarından farklı olarak depresyon düzeyi OLP' lu hastalarda kontrol grubuna göre daha yüksek olmakla birlikte istatistiksel olarak anlamlı bir farklılık saptanmamıştır.…”

Section: Discussionunclassified

EVALUATION OF LEVELS OF CORTIZOL, ANXIETY and DEPRESSION in PATIENTS WITH ORAL LICHEN PLANUS (OLP)

Pekiner¹,

Borahan²,

Özbayrak³

2014

MUSBED

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Oral liken planus (OLP)'lu bireylerde kortizol, anksiyete ve depresyon düzeylerinin değerlendirilmesi Amaç: Bu çalışmanın amacı; oral liken planus'lu bireylerde kortizol ve anksiyete/ depresyon düzeylerini değerlendirmek ve psikolojik faktörlerin oral liken planus (OLP)'un etyolojisindeki etkilerini saptamaktır. Yöntem: Marmara Üniversitesi Dişhekimliği Fakültesi Oral Diagnoz ve Radyoloji Anabilim Dalı Kliniği'ne başvuran, OLP klinik ön tanısı konmuş 30 birey hasta grubunu, sağlıklı 30 birey ise kontrol grubunu oluşturmuştur. OLP ön tanılı bireylerden kliniğimizde biyopsi materyali alınarak tanı histopatolojik olarak da desteklenmiştir. Hem çalışma hem de kontrol grubunun periferik kan kortizol düzeyleri değerlendirilmiş ve "Spielberger Durumluluk Kaygı Testi (DKT) -Süreklilik Kaygı Testi (SKT)" ile "Zung Depresyon Ölçeği (ZDP)" uygulanmıştır. Bulgular: Çalışma ve kontrol grubundaki hastaların kortizol, DKT ve ZDP değerleri ortalaması arasında anlamlı bir farklılık bulunmazken (p>0.05), çalışma grubunun SKT değerleri ortalaması kontrol grubundan istatistiksel olarak anlamlı düzeyde yüksektir (p<0.05). Sonuç: Oral Liken Planus'lu bireylerde süreklilik kaygı düzeyinin yüksek olması anksiyetenin bu hastalığın etyolojisinde önemli bir faktör olabileceğini ortaya koymaktadır. Anahtar sözcükler: Oral Liken Planus, anksiyete, depresyon ABS TRACT Evaluation of levels of cortizol, anxiety and depression in patients with oral lichen planus (OLP)Objectives: The aim of this study is to evaluate the levels of cortizol and anxiety/depression in individuals with oral lichen planus and determine the effects of psychologic factors on the etiology of Oral Lichen Planus. Method: 30 individuals pre-diagnosed with OLP who referred to Marmara University, Dentistry Faculty, Department of Oral Diagnosis and Radiology constitute the patient group while 30 healty individuals are control group. Pre-diagnosis of OLP of the patients was supported histopathologically with biopsies taken. Peripheral blood cortizol levels were evaluated and Spielberger State-Trait Anxiety Test with Zung depression Scale (ZDS) were administrated on both study and control group. Results: There was no statistical differences on the mean levels of Trait Anxiety Test and ZDS between the study and conrol group (p>0.05), while mean levels of State Anxiety Test of the study group was significantly higher than the mean levels of mean levels of State Anxiety Test of control group (p<0.05). Conclusion: Higher levels of state anxiety in individuals with oral lichen planus exhibits that anxiety is an important factor on the etiology of this disease.

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Section: Discussionunclassified

EVALUATION OF LEVELS OF CORTIZOL, ANXIETY and DEPRESSION in PATIENTS WITH ORAL LICHEN PLANUS (OLP)

Pekiner¹,

Borahan²,

Özbayrak³

2014

MUSBED

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“…These are conditions such as diabetes mellitus and impaired glucose tolerance, which are often associated with dermatologic lesions [62], and the simultaneous presence of diabetes, hypertension and OLP, known as ''Grinspan syndrome'' [63]. Stress and anxiety may form a starting point for the initiation of autoimmune reactions [64], although stress could also be consequent to OLP and not vice versa [65]. Other viral infections, such as EpsteinBarr virus [66,67] and torque teno virus [68,69], are also more prevalent among OLP patients than in healthy controls.…”

Section: Case-control Studymentioning

confidence: 99%

The magnitude of the association between hepatitis C virus infection and oral lichen planus: meta-analysis and case control study

et al. 2011

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Although hepatitis C virus (HCV) infection is associated with oral lichen planus (OLP), a case-control study and a meta-analysis were designed to investigate the magnitude of such an association. A total of 413 presumptive OLP patients (18-75 years) who referred to a dental clinic in Rasht (Iran) were consecutively selected. OLP was diagnosed clinically (typical forms) and histologically (atypical forms) by a calibrated examiner. A total of 487 adults (20-77 years) attending the same dental clinic were the controls. The two groups were homogeneous in terms of age, gender and occupation. Subjects were tested for anti-HCV antibodies. The odds ratio (OR) for OLP attributable to HCV infection was non-significant [OR 1.2, 95% confidence interval (95CI) 0.3-4.8], suggesting that the association between HCV and OLP was weak in the Iranian context. Meta-analysis of observational studies characteristics of primary studies were that cases were diagnosed clinically (only typical forms) and histologically and exposure was assessed through anti-HCV antibodies. Exposed/unexposed cases/controls were extracted and zero values were appropriately transformed. As much as 44 studies, including the present, were located. Publication bias could not be totally excluded. The pooled OR, estimated using the random-effect model, was 2.8 (95CI 2.4-3.2). Sensitivity analysis confirmed the robustness of results. Subgroup analysis showed non-significant differences between American/European and Asian/African studies. The fraction of global OLP cases associated with HCV (population attributable fraction) was 2.1% (95CI 1.9-2.2%). Although HCV and OLP were significantly associated, the majority of OLP patients were not affected by HCV.

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“…10,11 Psychological evaluation should be conducted to identify the etiology of the disease. 12,13 Various medicines and chemicals may cause OLP or OLP-like reactions 11 Virusesthat play a role in the etiology of OLP include the herpes viruses, especially the Epstein–Barr Virus, 14 human papillomavirus, 15 and hepatitis C virus (HCV). 16,17 Although it has been determined that OLP and viruses are related, the roles of bacteria in the etiology of OLP have not yet been determined.…”

Section: Introductionmentioning

confidence: 99%

Periodontopathogen profile of healthy and oral lichen planus patients with gingivitis or periodontitis

et al. 2013

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Oral lichen planus (OLP) is a chronic inflammatory disease that is frequently detected in oral tissues. The aim of our study was to identify the prevalence of the detection of periodontopathogenic microorganisms (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia and Treponema denticola in OLP patients and to compare with this prevalence of periodontopathogenic microorganisms in healthy non-OLP patients. Our study included 27 (18 chronic periodontitis (OLPP) and 9 gingivitis (OLPG)) patients diagnosed with OLP along with 26 (13 chronic periodontitis (HP) and 13 gingivitis (HG)) healthy non-OLP patients. The multiplex polymerase chain reaction (PCR) with subsequent reverse hybridization method (micro-IDent) was used for identifying periodontopathogenic microorganisms present in subgingival plaque samples. The percentages of detection for A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia and T. denticola in subgingival plaque samples taken from OLP patients (OLPG and OLPP) were 18.5%, 85.1%, 81.4%, 88.8% and 74%, respectively. Meanwhile, in the non-OLP patients (HG and HP), these values were 7.6%, 50%, 46.1%, 73% and 57.7%, respectively. Thus, comparing the non-OLP groups with the OLP groups, the periodontopathogens' percentages of detection in the OLP groups were higher than those in the non-OLP groups. According to our study results, OLP patients have higher levels of infection with A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia and T. denticola than non-OLP patients. We argue that the high percentages in patients with OLP may help identify the importance of periodontopathogenic microorganisms in the progress of periodontal diseases of OLP.

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Psychological health in patients with genital and oral erosive lichen planus

Cited by 83 publications

References 17 publications

EVALUATION OF LEVELS OF CORTIZOL, ANXIETY and DEPRESSION in PATIENTS WITH ORAL LICHEN PLANUS (OLP)

EVALUATION OF LEVELS OF CORTIZOL, ANXIETY and DEPRESSION in PATIENTS WITH ORAL LICHEN PLANUS (OLP)

The magnitude of the association between hepatitis C virus infection and oral lichen planus: meta-analysis and case control study

Periodontopathogen profile of healthy and oral lichen planus patients with gingivitis or periodontitis

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