Psychological interventions for adolescent psychosis: A pilot controlled trial in routine care

Browning, Sophie; Corrigall, Richard; Emsley, Richard; Jolley, Suzanne

doi:10.1016/j.eurpsy.2013.05.008

Cited by 17 publications

(28 citation statements)

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“…Seven studies were conducted in Europe, three in North America, two in Australia, one in Hong Kong and one in Mainland China. Eleven studies employed randomized controlled designs, one a controlled clinical trial (Browning et al, 2013) and two used an uncontrolled design (e.g., a cohort analytic design; Rossberg et al, 2010 and Rund et al, 1994). …”

Section: Resultsmentioning

confidence: 99%

“…One trial (O'Brien et al, 2014 and Miklowitz et al, 2014) examined those at risk of developing psychosis, whilst the remaining 13 examined those with early or first episode psychosis. Where details were recorded, service users were aged between 12 and 40 years old, and three studies exclusively examined service users with “very early-onset” psychosis (those with onset under-18 years old; Rund et al, 1994; Browning et al, 2013; Calvo et al, 2014). Limited information was provided about the identified carers.…”

Section: Resultsmentioning

confidence: 99%

“…Some interventions were delivered to carers only (Cozolino et al, 1988; McCann et al, 2013; Calvo et al, 2014; Chien et al, 2016a,b), whilst others invited service users to join all or part of the intervention (Goldstein et al, 1978; Rund et al, 1994; Zhang et al, 1994; Linszen et al, 1996; De Giacomo et al, 1997; Rossberg et al, 2010; Miklowitz et al, 2014; O'Brien et al, 2014). Three studies did not mention whether service users attended the sessions or not (Leavey et al, 2004; Gleeson et al, 2010; Browning et al, 2013). …”

Section: Resultsmentioning

confidence: 99%

“…Conversely, general functioning , measured across studies using the Children's/Global Assessment Scales (CGAS, Shaffer et al, 1983; GAS, Endicott et al, 1976), significantly improved for service users in the family intervention group ( k = 4, d = 0.74, 95 % CI [0.13, 1.36]) but such gains were not maintained by follow up. Two of the studies reporting improvements in general functioning were RCTs, had active comparison groups and were rated as moderate to strong on the EPHPP (Browning et al, 2013 and Calvo et al, 2014) whilst one study (Rund et al, 1994) used an historic cohort as a comparison and was rated as weak on the EPHPP.…”

Section: Resultsmentioning

confidence: 99%

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Do Family Interventions Improve Outcomes in Early Psychosis? A Systematic Review and Meta-Analysis

2017

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Family interventions for psychosis (FIp) are effective in reducing service user relapse and carer distress in people with schizophrenia-spectrum conditions. Several treatment and best practice guidelines recommend FIp for all people with schizophrenia. However, outcome findings in relation to early psychosis groups have been inconsistent. The current paper reports a systematic review and meta-analyses of articles that evaluated FIp in early psychosis with a clearly defined comparison group. A combination of electronic database searches (using PsychINFO, Medline, and CENTRAL), citation searches and hand searches of key journals and reviews was conducted. Peer-reviewed articles published in English from database inception to June 2016 were included. Methodological quality was assessed using the Effective Public Health Practice Project Quality Assessment Tool (EPHPP). Seventeen papers from 14 studies met inclusion criteria for review, the overall quality of which was moderate. Meta-analytic synthesis showed that FIp improved service user functioning and reduced the likelihood of relapse by the end of treatment. Psychotic symptoms were significantly reduced in the FIp group at follow up, but this was not evident at end of treatment. In terms of FIp target mechanisms, carers receiving FIp were more likely to shift from high to low expressed emotion and less likely to report patient focused criticism or engage in conflict communication than carers randomized to standard care. Carer burden and well-being were improved by the end of treatment but gains were not sustained at follow up. FIp had no impact on carer emotional over-involvement. The findings indicate that FIp is an effective intervention for early psychosis service users and their relatives. However, further research is required to establish which key therapeutic components of FIp are most effective for whom, in addition to understanding the mechanisms by which FIp might affect positive change.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Do Family Interventions Improve Outcomes in Early Psychosis? A Systematic Review and Meta-Analysis

2017

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“…Most therapies were described as interventions specific for bipolar disorder, but five therapies (two for patients with first episode and three for patients with early onset) were aimed at young people with affective and non-affective psychoses (online interventions such as so-called HORYZONS, 42 Early Psychosis Prevention and Intervention Centre, 43 social recovery cognitive behavioural therapy [CBT], 44 CBT for psychosis for adolescents 45 ) or other transdiagnostic populations (Youth Early-intervention Study 50 ). The number of sessions offered varied between eight and 36 and depended mostly on the type of therapy being provided rather than the stage of illness.…”

Section: Overview Of Therapy Modelsmentioning

confidence: 99%

An evidence map of psychosocial interventions for the earliest stages of bipolar disorder

Vallarino

Henry

Étain

et al. 2015

The Lancet Psychiatry

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Depression, schizophrenia, and bipolar disorder are three of the four most burdensome problems in people aged under 25 years. In psychosis and depression, psychological interventions are effective, low-risk, and high-benefit approaches for patients at high risk of first-episode or early-onset disorders. We review the use of psychological interventions for early-stage bipolar disorder in patients aged 15–25 years. Because previous systematic reviews had struggled to identify information about this emerging sphere of research, we used evidence mapping to help us identify the extent, distribution, and methodological quality of evidence because the gold standard approaches were only slightly informative or appropriate. This strategy identified 29 studies in three target groups: ten studies in populations at high risk for bipolar disorder, five studies in patients with a first episode, and 14 studies in patients with early-onset bipolar disorder. Of the 20 completed studies, eight studies were randomised trials, but only two had sample sizes of more than 100 individuals. The main interventions used were family, cognitive behavioural, and interpersonal therapies. Only behavioural family therapies were tested across all of our three target groups. Although the available interventions were well adapted to the level of maturity and social environment of young people, few interventions target specific developmental psychological or physiological processes (eg, ruminative response style or delayed sleep phase), or offer detailed strategies for the management of substance use or physical health.

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Cognitive behavioural therapy plus standard care versus standard care plus other psychosocial treatments for people with schizophrenia

Jones

Hacker

Meaden

et al. 2018

Cochrane Database of Systematic Reviews

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Psychological interventions for adolescent psychosis: A pilot controlled trial in routine care

Abstract: The study is the first to focus on an exclusively adolescent population, using appropriately adapted therapy protocols. Findings suggest that the interventions are feasible, acceptable and helpful for adolescents with psychosis. Larger randomised controlled trials are now needed.

Cited by 17 publications

References 10 publications

Do Family Interventions Improve Outcomes in Early Psychosis? A Systematic Review and Meta-Analysis

Do Family Interventions Improve Outcomes in Early Psychosis? A Systematic Review and Meta-Analysis

An evidence map of psychosocial interventions for the earliest stages of bipolar disorder

Cognitive behavioural therapy plus standard care versus standard care plus other psychosocial treatments for people with schizophrenia

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