Background: Since the emergence of a coronavirus disease (2019-nCoV) in December 2019, the whole world is in a state of chaos. Isolation strategy with quarantine is a useful model in controlling transmission and rapid spread. As a result, people remained at homes and disrupted their outside daily activities. It led to the closure of educational institutes, which is a source of many students to cope with numerous personal and familial issues. This study focuses on exploring the relationships and potential mediational pathways between mental health problems, illness perception, anxiety, and depression disorders.Method: The study incorporated snowball sampling techniques through a cross-sectional, web-based survey and recruited 500 students from different public and private universities from twin cities, Rawalpindi, and Islamabad from March 23 to April 15, 2020, during the coronavirus outbreak lockdown. The study used four instruments, Beck Depression Scale, Beck Anxiety Inventory, Revised Illness Perception Questionnaire, and The Warwick-Edinburgh Mental Well-being Scale for assessing depression, anxiety, illness perception, and mental health disorders.Results: The findings indicated normal (43.2%) mild (20.5%), moderate (13.6%), and severe (22.7%) level of anxiety prevalence in students. Results specified a normal (65.9%), mild (9.10%), moderate (9.12%), and severe (15.90%) depression prevalence, and findings stipulated that anxiety disorder prevalence was higher than the depression disorder. The correlational results specified a negative and significant relationship between mental health, illness perception, anxiety, and depression symptoms. The multiple regression analysis stated that anxiety and depression disorders mediated the relationship between mental health and present illness perception. The perception of illness exhibited a relation to depression and anxiety disorders.Conclusion: The study proposed a model to address mental health problems during the lockdown. The (2019-nCoV) illness perception developed mental disorders, including anxiety and depression, which has declined individuals' mental health. There is an urgent need for ongoing clinical examination and management to address psychological disorders, and findings suggest assessing mental health to combatting the pandemic worldwide. Findings recommend developing strategies to promote mental healthcare facilities during COVID-19 wide-ranging disasters. These results highlight the impending importance of devising strategies to treat mental health problems.