Psychometric and Psychophysiological Actions of Antipsychotics in Men

Janke, Wilhelm

doi:10.1007/978-3-642-67538-6_14

Cited by 6 publications

(6 citation statements)

References 54 publications

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“…As other studies illustrated [see Schelling, 1980] schizophrenic patients are hardly characterized by a gen eral intellectual and psychomotor performance deficit but by specific impairments of performance mainly re presented by a general delay of reaction speed [Easterbrock and Costello, 1970], Especially simple reaction time tasks [Janke, 1980] are severely impaired. The gross motor (tapping) and complex refined motor abilities (pegboard) are relevantly changed.…”

Section: Discussionmentioning

confidence: 94%

“…Gerhard and Hobi [1984] comparing haloperidol and thioridazine reported deteri oration of choice reaction time tasks, Eaton et al [1979] impairment of speed and precision tasks. Marder et al [1984] observed a reduction of attention, while Goldstone et al [1979] found impairment of paired compari son tasks [see Janke, 1980], Healthy volunteers taking 50 mg clozapine or 25, 50 and 100 mg zotepine and placebo had the highest reac tion times and highest mistakes during verum applica tion 6 h after intake. Acute or exacerbated schizophrenic patients taking fluperlapine showed no substantial dete rioration of reaction time in comparison to haloperidol.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of Sensorimotor and Cognitive Performance of Acute Schizophrenic Inpatients Treated with Remoxipride or Haloperidol

Classen

Laux²

1989

Neuropsychobiology

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29 acute schizophrenic patients according to DSM III and ICD-9 underwent examination of performance regarding cognitive and sensorimotor tasks at the beginning and the end of a 28-day neuroleptic treatment with remoxipride or haloperidol in a double-blind design. Psychopathological symptoms were assessed by Brief Psychiatric Rating Scale and Clinical Global Impression, extrapyramidal side effects (ESE) were rated by Simpson-Angus scale. A significant treatment effect for acoustic reaction time tasks, naming of colored stripes and interference could be demonstrated, whereas tapping revealed a significant effect of duration of treatment. Interaction effects regarding time of faults in line tracing, visual sensorimotor reaction time task and interference factor (Stroop test) could be observed. ESE and impairment of performance occurred simultaneously and ESE vanished with clinical improvement. Performance deficits were more pronounced in patients assigned to remoxipride treatment. Possible differential effects on performance under neuroleptic drug treatment will be discussed.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Comparison of Sensorimotor and Cognitive Performance of Acute Schizophrenic Inpatients Treated with Remoxipride or Haloperidol

Classen

Laux²

1989

Neuropsychobiology

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“…This anaesthetic technique was chosen be-In a recent editorial in this journal [1] Jelicic and Bonke cause it preserves neurophysiological functions [5,6] commented on the present state of clinical research which process information in the therapeutic sugdealing with the topic of learning during anaesthesia. This anaesthetic technique was chosen be-In a recent editorial in this journal [1] Jelicic and Bonke cause it preserves neurophysiological functions [5,6] commented on the present state of clinical research which process information in the therapeutic sugdealing with the topic of learning during anaesthesia.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, a randomized, controlled, double‐blind study was performed to assess the effect of intra‐operative positive suggestions on patients receiving a classic neurolept‐anaesthesia technique using droperidol and fentanyl. This anaesthetic technique was chosen because it preserves neurophysiological functions [5, 6] which process information in the therapeutic suggestions made during general anaesthesia.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic suggestions given during neurolept-anaesthesia decrease post-operative nausea and vomiting

Eberhart

Doring²,

Holzrichter³

et al. 1998

Eur J Anaesthesiol

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A double-blind randomized study was performed in 100 patients undergoing thyroidectomy to evaluate the effect of positive therapeutic suggestions made during neurolept-anaesthesia. The classic droperidol-fentanyl-N2O technique was used as these drugs preserve the neurophysiological functions required to process the information in the therapeutic suggestions given during general anaesthesia. Patients in the suggestion group heard positive non-affirmative suggestions during the whole operation. An autoreverse tape player was used. The control group listened to an empty tape. Both groups were comparable with respect to demographic variables, anaesthetic technique, drug dosage, duration of anaesthesia and surgery. Patients in the suggestion group suffered significantly less from post-operative nausea or vomiting (suggestion: 47.2% vs. control: 85.7%) and required less anti-emetic treatment (suggestion: 30.6% vs. control: 68.6%). We conclude that therapeutic suggestions heard during neurolept-anaesthesia are processed and decrease post-operative nausea and vomiting in patients after thyroidectomy.

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“…neurolept-anaesthesia technique using droperidol and fentanyl. This anaesthetic technique was chosen be-In a recent editorial in this journal [1] Jelicic and Bonke cause it preserves neurophysiological functions [5,6] commented on the present state of clinical research which process information in the therapeutic sugdealing with the topic of learning during anaesthesia.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic suggestions given during neurolept-anaesthesia decrease post-operative nausea and vomiting

Eberhart¹,

Doring²,

Holzrichter³

et al. 1998

European Journal of Anaesthesiology

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respect to demographic variables, anaesthetic technique, drug dosage, duration of anaesthesia and sur-A double-blind randomized study was performed in gery. Patients in the suggestion group suffered 100 patients undergoing thyroidectomy to evaluate significantly less from post-operative nausea or vomthe effect of positive therapeutic suggestions made iting (suggestion: 47.2% vs. control: 85.7%) and reduring neurolept-anaesthesia. The classic droperidolquired less anti-emetic treatment (suggestion: 30.6% fentanyl-N 2 O technique was used as these drugs prevs. control: 68.6%). We conclude that therapeutic sugserve the neurophysiological functions required to gestions heard during neurolept-anaesthesia are proprocess the information in the therapeutic suggestions cessed and decrease post-operative nausea and given during general anaesthesia. Patients in the sugvomiting in patients after thyroidectomy. gestion group heard positive non-affirmative suggestions during the whole operation. An autoreverse Keywords: post-operative nausea and vomiting;therapeutic suggestions, neurolept-anaesthesia, dro-tape player was used. The control group listened to an empty tape. Both groups were comparable with peridol.

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Psychometric and Psychophysiological Actions of Antipsychotics in Men

Cited by 6 publications

References 54 publications

Comparison of Sensorimotor and Cognitive Performance of Acute Schizophrenic Inpatients Treated with Remoxipride or Haloperidol

Comparison of Sensorimotor and Cognitive Performance of Acute Schizophrenic Inpatients Treated with Remoxipride or Haloperidol

Therapeutic suggestions given during neurolept-anaesthesia decrease post-operative nausea and vomiting

Therapeutic suggestions given during neurolept-anaesthesia decrease post-operative nausea and vomiting

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