“…Nevertheless, we believe that the present preliminary data could contribute to finding new ways to implement brain indications related to cognitive functioning as an add-on tool in the conventional management of alcohol-dependent patients by promoting, for instance, the replication of such results through multicenter studies (Campanella, 2016;Campanella et al, 2019). Indeed, the current tools used for risk assessment suffer from the main problem that several factors that differ in nature need to be taken into account to predict relapse, e.g., the occurrence of negative life events, the motivation for change, coping resources, craving experiences and mood status (Miller et al, 1996), the identification of high-risk drinking situations (Menges et al, 2008), the need to identify individual bestsuited treatments (Wietkiewitz and Marlatt, 2007), implicit attitudes (approach, avoidance) towards alcohol (Stacy and Wiers, 2010), or even feelings of shame (Randles and Tracy, 2013). Although brain imaging studies can index functional neural changes accompanying abstinence in groups of patients by, for instance, using functional magnetic resonance imaging studies (e.g., Grusser et al, 2004), in a clinical context it will always be difficult to implement an experimental protocol that can take all these variables into account and to apply it to a singular patient.…”