Psychometric evaluation of the negative syndrome of schizophrenia

García-Portilla, María Paz; Álvarez, Leticia García; Sáiz, Pilar A.; Al‐Halabí, Susana; Bobes-Bascaran, María Teresa; Bascarán, María Teresa Bobes; Muñiz, José; Bobes, Julio

doi:10.1007/s00406-015-0595-z

Cited by 53 publications

(32 citation statements)

References 41 publications

(81 reference statements)

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“…Existing rating scales can be divided into older, first-generation and newer, second-generation tools (Marder and Kirkpatrick, 2014). First-generation tools, such as the PANSS negative subscale, BPRS, and SANS are limited in that they do not capture all negative symptoms (such as asociality, avolition, and anhedonia), and rely more heavily on behavior for assessment rather than internal experiences (Paz Garcia-Portilla et al, 2015). The PANSS, a comprehensive scale to asses psychopathology (Kay et al, 1987), was not designed to measure negative symptoms independently (Marder and Kirkpatrick, 2014).…”

Section: Potential Sources Of Heterogeneity In Extant Studiesmentioning

confidence: 99%

Oxytocin effects in schizophrenia: Reconciling mixed findings and moving forward

Bradley

Woolley

2017

Neuroscience & Biobehavioral Reviews

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Schizophrenia is a severe mental illness that causes major functional impairment. Current pharmacologic treatments are inadequate, particularly for addressing negative and cognitive symptoms of the disorder. Oxytocin, a neuropeptide known to moderate social behaviors, has been investigated as a potential therapeutic for schizophrenia in recent years. Results have been decidedly mixed, leading to controversy regarding oxytocin's utility. In this review, we outline several considerations for interpreting the extant literature and propose a focused agenda for future work that builds on the most compelling findings regarding oxytocin effects in schizophrenia to date. Specifically, we examine underlying causes of heterogeneity in randomized clinical trials (RCTs) conducted thus far and highlight the complexity of the human oxytocin system. We then review evidence of oxytocin's effects on specific deficits in schizophrenia, arguing for further study using objective, precise outcome measures in order to determine whether oxytocin has the potential to improve functional impairment in schizophrenia.

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Section: Potential Sources Of Heterogeneity In Extant Studiesmentioning

confidence: 99%

Oxytocin effects in schizophrenia: Reconciling mixed findings and moving forward

Bradley

Woolley

2017

Neuroscience & Biobehavioral Reviews

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“…This is due to the pathomorphism of the "classic" clinical picture of the disease, the similarity of a number of symptoms with manifestations of other nosological forms [4]. Of particular importance in preventing diagnostic and expert mistakes in assessing the negative symptoms of schizophrenia are specific research methods, such as qualification scales [5,6]. There are a large number of scales to evaluate it.…”

Section: Introductionmentioning

confidence: 99%

Paranoid Schizophrenia Negative Symptoms Features in Case of Presence of Musical Ear

Kostyuchenko

Filts

2018

EUREKA: Health Sciences

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In our work, we propose one of the options for a prognostic criterion, which at the beginning of the disease can provide sufficient evidence to predict the form and severity of negative symptoms in schizophrenia. Aim. To investigate the influence of the presence of ear on music on the degree of severity of deficiency symptoms in paranoid schizophrenia. The study was conducted on the basis of the third clinical department of the Lviv Regional Clinical Psychiatric Hospital for the period of 2015. 40 patients with paranoid form of schizophrenia, aged 18 to 35, were examined, of which: group I – 20 patients with advanced ear on music (average age 28.60±1.01 years) and group II – 20 patients with no ear on music (average age 27.30±1.15 years). The main methods of studying the observation groups were: clinical-psychopathological, pathopsychological, and statistical. The pathopsychological study of the evaluation of negative symptoms was conducted using the "Qualitative Assessment Scale for Positivity, Negative and General Psychopathological Syndromes" (PANSS – Positive and Negative Syndrome Scale), namely, its PANSS-NS subscale. Comparison of the probability of the difference between the average indices of unrelated groups was carried out using the Mann-Whitney method, comparing the relative parameters of the distribution structure by the xi-square criterion. Analysis of the results of the study shows that in patients with developed ear on music, the level of deficiency symptoms of negative symptoms under the PANSS-NS subclass is 2.2 times lower (p <0.01) than in patients with no developed ear on music: 2.04±0.14 against 4.46±0.17 points, respectively. Comparing the key indicators of the PANSS-NS subscale in patients with paranoid schizophrenia with advanced ear on music, it was found that the manifestations of "Violations of abstract thinking" (N5 – 2.35±0.15 points), "Violation of spontaneity and smoothness in the conversation" (N6 – 2.30±0.15 points) and "Stereotyped thinking" (N7 – 2.20±0.16 points). All these negative symptoms were in patients with muscular earache with significantly lower scores: from lack of severity (1 point) to weakness (3 points). The lack of expressiveness (1 point) was most common in N4 "Passive-apathy social strangeness " - 35.00±10.67 % of patients, very weak severity (2 points) - for N1 "Blurred passion" - 75.00±9.68 % of patients (p <0.05 with the proportion of negative symptoms 1 and 3 points), weakness (3 points) - for N5 – 45.00±11.12 % of patients (p <0.05 with the proportion of negative symptoms 1 point ) The highest proportion (70.00±10.25 %, p <0.05 with a share of negative symptoms of 6 points) of patients with paranoid schizophrenia without ear on music had a high severity (5 points) of rigidity and stereotyping of thinking (N7). The obtained data prove the influence of the factor of the presence of ear on music on deficit syndrome, as well as on the forms and degree of severity of negative symptoms in paranoid schizophrenia.

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“…The validity of previous scales for assessing negative symptoms has been questioned [15,16]. Subsequently, the NIMH-MATRICS consensus statement called for the development of a new instrument that more accurately reflects current concepts of negative symptoms [17].…”

Section: Introductionmentioning

confidence: 99%

“…Subsequently, the NIMH-MATRICS consensus statement called for the development of a new instrument that more accurately reflects current concepts of negative symptoms [17]. In response, the Clinical Assessment Interview for Negative Symptoms (CAINS) was created with increased validity [15,18]. A review by Lavelle et al [19] noted that variations between past findings may be linked not only with differences in assessment methods, but also with the heterogeneity of samples used both within and across studies.…”

Section: Introductionmentioning

confidence: 99%

Negative Symptoms and Avoidance of Social Interaction: A Study of Non-Verbal Behaviour

et al. 2017

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Background: Non-verbal behaviour is fundamental to social interaction. Patients with schizophrenia display an expressivity deficit of non-verbal behaviour, exhibiting behaviour that differs from both healthy subjects and patients with different psychiatric diagnoses. The present study aimed to explore the association between non-verbal behaviour and symptom domains, overcoming methodological shortcomings of previous studies. Sampling and Methods: Standardised interviews with 63 outpatients diagnosed with schizophrenia were videotaped. Symptoms were assessed using the Clinical Assessment Interview for Negative Symptoms (CAINS), the Positive and Negative Syndrome Scale (PANSS) and the Calgary Depression Scale. Independent raters later analysed the videos for non-verbal behaviour, using a modified version of the Ethological Coding System for Interviews (ECSI). Results: Patients with a higher level of negative symptoms displayed significantly fewer prosocial (e.g., nodding and smiling), gesture, and displacement behaviours (e.g., fumbling), but significantly more flight behaviours (e.g., looking away, freezing). No gender differences were found, and these associations held true when adjusted for antipsychotic medication dosage. Conclusions: Negative symptoms are associated with both a lower level of actively engaging non-verbal behaviour and an increased active avoidance of social contact. Future research should aim to identify the mechanisms behind flight behaviour, with implications for the development of treatments to improve social functioning.

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Psychometric evaluation of the negative syndrome of schizophrenia

Cited by 53 publications

References 41 publications

Oxytocin effects in schizophrenia: Reconciling mixed findings and moving forward

Oxytocin effects in schizophrenia: Reconciling mixed findings and moving forward

Paranoid Schizophrenia Negative Symptoms Features in Case of Presence of Musical Ear

Negative Symptoms and Avoidance of Social Interaction: A Study of Non-Verbal Behaviour

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