Psychometric properties of the Menopause Specific Quality of Life questionnaire among Thai women with a history of breast cancer

Phligbua, Warunee; Smith, Ellen M. Lovie; Barton, Debra L.

doi:10.1016/j.ejon.2018.08.008

Cited by 7 publications

(11 citation statements)

References 26 publications

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“…The current results support the good psychometric properties of the MENQOL (internal consistency reliability, convergent reliability, and structural validity) found in other populations such as breast cancer survivors [ 24 , 25 ] and participants with diabetes [ 26 ].…”

Section: Discussionsupporting

confidence: 81%

Psychometric Evaluation of the MENQOL Instrument in Women Experiencing Vasomotor Symptoms Associated with Menopause

Schultz,

Morga,

Siddiqui

et al. 2024

Adv Ther

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Introduction Vasomotor symptoms (VMS) associated with menopause can negatively affect health-related quality of life (HRQoL). The Menopause-Specific Quality of Life (MENQOL) questionnaire has been developed to assess QOL specific to menopause. The objective of the current study was to assess the psychometric properties, sensitivity to change, and clinically meaningful within-patient change of the MENQOL using data from the fezolinetant SKYLIGHT 1 and 2 studies in individuals with VMS. Methods Individuals aged ≥ 40 to ≤ 65 years with moderate-to-severe VMS (≥ seven hot flashes/day) were enrolled. In addition to MENQOL, eight patient-reported outcome (PRO) measures were used for the psychometric evaluation. All PRO assessments were completed at weeks 4 and 12 during the treatment period, and most were completed at baseline. Psychometric analyses included factor analysis and reliability, construct validity, and sensitivity to change assessments. The within-patient threshold for a clinically meaningful change in MENQOL was derived. Results In total, 1022 individuals were included from SKYLIGHT 1 and 2. Mean MENQOL total score at baseline was 4.30, improving to 3.16 at week 12. The confirmatory factor analysis supported established MENQOL domain structure, including the overall score. The internal consistency of the MENQOL overall and domain scores was supported using Cronbach’s alpha and McDonald’s omega, and MENQOL construct validity was supported for overall and domain scores. Item-to-item and item-total correlations were generally sufficient, and moderate test–retest reliability was noted. The scales against which construct validity and responsiveness for MENQOL domains were examined were moderately related to the MENQOL domains in general, providing additional support for acceptable measurement properties of MENQOL in this population. A reduction in MENQOL overall score of ≥ 0.9 points was identified as responding to treatment (a clinically important threshold). Thresholds of 2.0 points for the vasomotor domain and 0.9 for the psychosocial domain were estimated, in addition to distribution-based threshold estimates of 0.8 and 1.2 for the physical and sexual domains, respectively. Conclusions The psychometric properties of the MENQOL overall and domain scores support use of this instrument to capture experiences among individuals with moderate-to-severe VMS associated with menopause and assess related endpoints in clinical trials. Trial Registration ClinicalTrials.gov identifiers NCT04003155 and NCT04003142. Supplementary Information The online version contains supplementary material available at 10.1007/s12325-024-02787-z.

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Section: Discussionsupporting

confidence: 81%

Psychometric Evaluation of the MENQOL Instrument in Women Experiencing Vasomotor Symptoms Associated with Menopause

Schultz,

Morga,

Siddiqui

et al. 2024

Adv Ther

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“…The fourth section contained the Menopause-Specific Quality of Life Questionnaire (MENQOL). It consists of 29 items with four domains: vasomotor, psychosocial, physical and sexual (Cronbach’s α 0.86) [ 12 ]. The final section contained the International Physical Activity Questionnaire (Cronbach’s α 0.63–0.85), a self-reported questionnaire used worldwide which assesses the general PA over the last seven days [ 13 ].…”

Section: Methodsmentioning

confidence: 99%

Physical activity, anthropometric measurements, quality of life and menopausal symptoms among South-Indian women

2023

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Introduction Menopause is the period when the reproductive capacity ceases in women’s life. A wide range of symptoms occur as a consequence of estrogen decrease during menopause. Evidence suggests that physically active women have a better quality of life (QoL) and fewer menopausal symptoms. The aim of the study was to analyze the relationship between physical activity (PA), anthropometric measurements, QoL and menopausal symptoms. Material and method A cross-sectional study was conducted online through WhatsApp and Facebook and via email among menopausal women (April 2021 – June 2021). In total 168 responses were received; 153 responses were included in the study based on the inclusion criteria. Participants were asked to complete the details of anthropometric measurements, the Menopause Rating Scale (MRS), the International Physical Activity Questionnaire and the Menopause-Specific Quality of Life Questionnaire (MENQOL). Results The majority of menopausal women complained of one or more symptoms in the MRS. A statistically significant difference was noted between the body mass index (BMI) and the menopausal symptoms such as irritability and depressive mood. There was an association between PA and MENQOL physical and sexual domains ( p -value ≤ 0.05). Conclusions There was an association between PA, menopausal symptoms, BMI and MENQOL physical and sexual domains. Hence, moderate PA promotion is recommended among middle aged women to have a healthy menopausal transition.

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“…Of these 40 PROMs, four had adequate measurement properties and therefore met the minimum criteria for consideration: The Greene Climacteric Scale (GCS), [13][14][15][16] Hot Flash Related Daily Interference Scale (HFRDIS), [17][18][19][20][21] the short form of the HFRDIS, the Hot Flash Interference Scale (HFI), 20,21 and the Menopause Specific Quality of Life Questionnaire (MENQOL) [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] (Table 2). Three of these PROMs had very low-quality evidence to support content validity (GCS, HFRDIS, HFI).…”

Section: Study Selectionmentioning

confidence: 99%

“…These PROMs were developed specifically for postmenopausal women: GCS, [13][14][15][16] HFRDIS, 17-21 HFI, 20,21 and the MENQOL. [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] Some PROMs, such as the GCS, include symptoms, which are unlikely to be due to menopause, such as "parts of the body feeling numb" and "loss of interest in most things." The HFRDIS [17][18][19][20][21] contains 10 items relating to interference of VMS on aspects of life, and the HFI 20,21 is a shortened three-item version with items relating to interference with sleep, mood, and concentration.…”

Section: Prom Characteristicsmentioning

confidence: 99%

Recommended measurement instruments for menopausal vasomotor symptoms: the COMMA (Core Outcomes in Menopause) consortium

Lensen,

Paramanandam,

Gabes

et al. 2024

Menopause

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Objective The aim of the study is to identify suitable definitions and patient-reported outcome measures (PROMs) to assess each of the six core outcomes previously identified through the COMMA (Core Outcomes in Menopause) global consensus process relating to vasomotor symptoms: frequency, severity, distress/bother/interference, impact on sleep, satisfaction with treatment, and side effects. Methods A systematic review was conducted to identify relevant definitions for the outcome of side-effects and PROMs with acceptable measurement properties for the remaining five core outcomes. The consensus process, involving 36 participants from 16 countries, was conducted to review definitions and PROMs and make final recommendations for the measurement of each core outcome. Results A total of 21,207 publications were screened from which 119 reporting on 40 PROMs were identified. Of these 40 PROMs, 36 either did not adequately map onto the core outcomes or lacked sufficient measurement properties. Therefore, only four PROMs corresponding to two of the six core outcomes were considered for recommendation. We recommend the Hot Flash Related Daily Interference Scale to measure the domain of distress, bother, or interference of vasomotor symptoms and to capture impact on sleep (one item in the Hot Flash Related Daily Interference Scale captures interference with sleep). Six definitions of “side effects” were identified and considered. We recommend that all trials report adverse events, which is a requirement of Good Clinical Practice. Conclusions We identified suitable definitions and PROMs for only three of the six core outcomes. No suitable PROMs were found for the remaining three outcomes (frequency and severity of vasomotor symptoms and satisfaction with treatment). Future studies should develop and validate PROMs for these outcomes.

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Psychometric properties of the Menopause Specific Quality of Life questionnaire among Thai women with a history of breast cancer

Cited by 7 publications

References 26 publications

Psychometric Evaluation of the MENQOL Instrument in Women Experiencing Vasomotor Symptoms Associated with Menopause

Psychometric Evaluation of the MENQOL Instrument in Women Experiencing Vasomotor Symptoms Associated with Menopause

Physical activity, anthropometric measurements, quality of life and menopausal symptoms among South-Indian women

Recommended measurement instruments for menopausal vasomotor symptoms: the COMMA (Core Outcomes in Menopause) consortium

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