Psychoneurodendocrine correlates of lymphocyte subsets during healthy ageing

Collaziol, Diego; Luz, Clarice; Dornelles, Fabiana Noronha; Cruz, Ivana Beatrice Mânica da; Bauer, Moisés Evandro

doi:10.1016/j.mad.2003.10.009

Cited by 27 publications

(26 citation statements)

References 57 publications

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“…In addition, a complete hematological analysis revealed no age-related changes (i.e. lymphocyte counts or hemoglobin levels for example) [30] .…”

Section: Demographic Data and Nutritional Analysesmentioning

confidence: 91%

“…We have recently demonstrated that healthy aging was associated with significant psychological distress and increased salivary cortisol ( ϳ 45%) levels in parallel with changes in T-cell subsets [30] and unaltered production of pro-inflammatory cytokines [31] . It was also observed that cortisol levels were positively correlated to cytokines [31] .…”

Section: Introductionmentioning

confidence: 99%

“…Here, we further investigated the neuroendocrine/ immunoregulation during healthy aging. We hypothesized that higher cortisol levels observed during aging [30] would render peripheral lymphocytes more resistant to GCs. This was achieved by investigating the ability of GCs (dexamethasone and cortisol) and DHEA to suppress T-cell proliferation in vitro.…”

Section: Introductionmentioning

confidence: 99%

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Healthy Aging Is Associated with Unaltered Production of Immunoreactive Growth Hormone but Impaired Neuroimmunomodulation

Luz

Collaziol

Preissler

et al. 2006

Neuroimmunomodulation

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Background: Both endocrine and immune systems are continuously remodeled during aging. Objective: Here, we investigated to what extent adrenal and somatosenescence are associated reciprocal changes in the immune system during strictly healthy aging. Methods: Forty-six elderly subjects and 33 young adults were recruited according to the health criteria of the SENIEUR protocol. Peripheral blood mononuclear cells were isolated and stimulated in vitro with lipopolysaccharide or phytohemagglutinin to assess the production of immunoreactive growth hormone (GH). Peripheral sensitivity to steroids was assessed in vitroby dexamethasone-, cortisol- or dehydroepiandrosterone (DHEA)-induced inhibition of T-cell proliferation. DHEA and GH levels were measured by radioimmunoassays. Results: Healthy elderly had lower salivary DHEA and serum GH levels (somatosenescence). They presented reduced T-cell sensitivity to dexamethasone but similar cellular sensitivities to cortisol and DHEA. Their cells produced similar levels of immunoreactive GH compared to the cells of young adults. Conclusions: These data indicate that healthy aging is associated with adrenal and somatosenescence as well as impaired neuroendocrine immunoregulation at the level of the lymphocyte. In addition, somatosenescence may not be associated with a reciprocal decline in immunoreactive GH.

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“…In addition, a complete hematological analysis revealed no age-related changes (i.e. lymphocyte counts or hemoglobin levels for example) [30] .…”

Section: Demographic Data and Nutritional Analysesmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Healthy Aging Is Associated with Unaltered Production of Immunoreactive Growth Hormone but Impaired Neuroimmunomodulation

Luz

Collaziol

Preissler

et al. 2006

Neuroimmunomodulation

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“…In particular, it was found that strictly healthy (SE-NIEUR) elders were significantly more stressed, anxious and depressed than young adults [12,13] . In parallel to psychological distress, we have also observed that SE-NIEUR elders had significantly higher (approx.…”

Section: Healthy Aging Is Associated With Emotional Distress and Incrmentioning

confidence: 97%

“…We have previously investigated the role of psychoneuroendocrine factors in regulating the distribution of peripheral T cell subsets during healthy aging [13] . The mechanisms underlying the regulation of the peripheral pool of lymphocytes are still largely unknown.…”

Section: Similarities Between Aging and Chronic Gc Exposurementioning

confidence: 99%

Chronic Stress and Immunosenescence: A Review

Bauer

2008

Neuroimmunomodulation

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This paper reviews recent work suggesting that human immunosenescence may be closely related to both chronic stress and stress hormones. The age-related immunological changes are also similarly found during chronic stress or glucocorticoid exposure. These data further suggest that endogenous glucocorticoids could be associated with immunosenescence. When compared with young subjects, healthy elders are emotionally distressed in parallel to increased cortisol/dehydroepiandrosterone ratio. Furthermore, chronically stressed elderly subjects may be particularly at risk of stress-related pathology because of further alterations in glucocorticoid-immune signaling. Age-related increase in cortisol/dehydroepiandrosterone ratio could be understood as a major determinant of immunological changes observed during aging. Strictly healthy elders are somewhat protected from chronic stress exposure and show normal cortisol levels and increased T cell function. This information adds a new key dimension to the biology of aging and stress.

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Fas (CD95)/FasL (CD178) system during ageing

Lagunas‐Rangel

2023

Cell Biology International

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The Fas/FasL system plays a central role in the physiological regulation of apoptosis and has been implicated in the pathogenesis of several neoplasms and diseases of the immune system. Until now, it has received little attention in the context of ageing, but there is sufficient evidence that it plays an important role in this process and its deregulation favours the development of age‐related diseases such as osteoarthritis, diabetes, eye diseases, ischaemic processes, anaemia, Alzheimer's disease and cancer. With this in mind, the aim of this work was to describe the main changes that occur in the Fas/FasL system during ageing and their association with the development of age‐related diseases. Furthermore, it discusses how exercise and diet, considered the cornerstone of almost all healthy ageing programmes, produce beneficial effects through the regulation of the Fas/FasL system.

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Psychoneurodendocrine correlates of lymphocyte subsets during healthy ageing

Cited by 27 publications

References 57 publications

Healthy Aging Is Associated with Unaltered Production of Immunoreactive Growth Hormone but Impaired Neuroimmunomodulation

Healthy Aging Is Associated with Unaltered Production of Immunoreactive Growth Hormone but Impaired Neuroimmunomodulation

Chronic Stress and Immunosenescence: A Review

Fas (CD95)/FasL (CD178) system during ageing

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