Psychoneuroimmunology of mental disorders

Soria, Virginia; Uribe, Javiera; Salvat‐Pujol, Neus; Palao, Diego; Menchón, José M.; Labad, Javier

doi:10.1016/j.rpsmen.2017.07.002

Cited by 25 publications

(35 citation statements)

References 77 publications

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“…It should be noted that, although we included several blood biomarkers in the study, none of them were included in the model. This is especially surprising in the case of PCR, an inflammatory biomarker, since some authors have suggested a dysregulation of the immune response and a proinflammatory state in these patients [56]. We think this may be related to the classification formula’s inclusion of the metabolic syndrome, a pro-inflammatory state that could be redundant with inflammatory blood biomarkers, thus prevailing over them in the model.…”

Section: Discussionmentioning

confidence: 94%

Classification of patients with bipolar disorder using k-means clustering

et al. 2019

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IntroductionBipolar disorder (BD) is a heterogeneous disorder needing personalized and shared decisions. We aimed to empirically develop a cluster-based classification that allocates patients according to their severity for helping clinicians in these processes.MethodsNaturalistic, cross-sectional, multicenter study. We included 224 subjects with BD (DSM-IV-TR) under outpatient treatment from 4 sites in Spain. We obtained information on socio-demography, clinical course, psychopathology, cognition, functioning, vital signs, anthropometry and lab analysis. Statistical analysis: k-means clustering, comparisons of between-group variables, and expert criteria.Results and discussionWe obtained 12 profilers from 5 life domains that classified patients in five clusters. The profilers were: Number of hospitalizations and of suicide attempts, comorbid personality disorder, body mass index, metabolic syndrome, the number of comorbid physical illnesses, cognitive functioning, being permanently disabled due to BD, global and leisure time functioning, and patients’ perception of their functioning and mental health. We obtained preliminary evidence on the construct validity of the classification: (1) all the profilers behaved correctly, significantly increasing in severity as the severity of the clusters increased, and (2) more severe clusters needed more complex pharmacological treatment.ConclusionsWe propose a new, easy-to-use, cluster-based severity classification for BD that may help clinicians in the processes of personalized medicine and shared decision-making.

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Section: Discussionmentioning

confidence: 94%

Classification of patients with bipolar disorder using k-means clustering

et al. 2019

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“…A particularly interesting hypothesis to be tested relies on the contribution of personality traits, given the apparent different role of conscientiousness in toilet paper hoarding during the COVID-19 pandemic (Garbe, Rau & Toppe, 2020) and in hoarding symptoms in people with OCD (LaSalle-Ricci et al, 2006;. Research on neurobiological determinants might study the contribution of stressrelated biomarkers, including hypothalamic-pituitary-adrenal (HPA) axis hormones and cytokines, given the implication of these biomarkers in stress-related pathologies (Soria et al, 2018;Russell & Lightman, 2019). Future studies also might want to address the study of faeces, as gut microbiota has emerged as a key player in the control of the HPA axis, especially during stressful situations caused by real or perceived homeostatic challenges (Foster, Rinaman & Cryan, 2017).…”

Section: Gaps In the Literature And Future Directionsmentioning

confidence: 99%

Peer Review #2 of "A systematic review and realist synthesis on toilet paper hoarding: COVID or not COVID, that is the question (v0.2)"

2021

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To explore whether the coronavirus disease 2019 (COVID-19) pandemic is associated with toilet paper hoarding and to assess which risk factors are associated with the risk of toilet paper hoarding.Design: A systematic review and realist review were conducted.Data sources: PubMed, Web of Science, Scopus and PsycINFO were searched (systematic review). PubMed, pre-prints and grey literature were also searched (realist review). The databases were searched from inception until June 2020. Study selection:There were no restrictions on the study design.Outcomes and measures: For the systematic review, toilet paper hoarding was the main outcome, and pathological use of toilet paper was the secondary outcome. For the realist review, the contextmechanisms-outcome (CMO) scheme included the COVID-19 pandemic (context), four proposed mechanisms, and one outcome (toilet paper hoarding). The four potential mechanisms were 1) gastrointestinal mechanisms of COVID-19 (e.g., diarrhoea), 2) social cognitive biases, 3) stress-related factors (mental illnesses, personality traits), and 4) cultural aspects (e.g., differences between countries).Eligibility criteria for selecting studies: All studies of human populations were considered (including general population studies and clinical studies of patients suffering from mental health problems). Results:The systematic review identified 14 studies (8 studies for the main outcome, 6 studies for the secondary outcome). Three surveys identified the role of the COVID-19 threat in toilet paper hoarding in the general population. One study pointed to an association between a personality trait (conscientiousness) and toilet paper buying and stockpiling as well as an additional significant indirect effect of emotionality through the perceived threat of COVID-19 on toilet paper buying and stockpiling. Six case reports of pathological use of toilet paper were also identified, although none of them were associated with the COVID-19 pandemic. The realist review suggested that of all the mechanisms, social cognitive biases and a bandwagon effect were potential contributors to toilet paper hoarding in the general population. The stressful situation (COVID-19 pandemic) and some personality traits (conscientiousness) were found to be associated with toilet paper hoarding. Cultural differences were

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“…With the release of these cytokines, an activation state of low-grade inflammation is reached, which worsens the prognosis of patients in relation to positive and negative psychotic symptoms, cognitive impairment, and loss of brain volume. In addition, an over activation of the HPA axis is observed, with a sustained release of cortisol [33]. One of the classic symptoms of schizophrenia, but which is not given much attention, is a pain without experimental provocation, including the percentage of people with this disease indicating which pain is not high.…”

Section: Pain Comorbiditymentioning

confidence: 99%

Pharmaceutical and Botanical Management of Pain Associated with Psychopathology: A Narrative Review

Lozano¹,

Sánchez²,

Rodríguez³

et al. 2020

Behavioral Pharmacology - From Basic to Clinical Research

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Generally, pain can be described as an unpleasant sensory or emotional experience associated with tissue damage. Chronic pain has become a public health problem because among 35 and 75% of the world population has shown the symptom. In particular, neuropathic pain has shown high comorbidity disorders such as anxiety and depression. Conventional therapies for treating pain include nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, tricyclic antidepressants, anticonvulsants, and opioids, which usually cause some side effects such as gastritis, headache, liver and kidney toxicity, and drug dependence. Conventional pharmaceuticals also tend to be expensive, and they cannot be easily afforded in developing countries, which have led to the use of natural products as an alternative treatment. In this chapter, we reviewed the current research of natural products for pain treatment. We also describe preclinical studies that assess the effect of some natural products on pain therapy, phytochemistry research, toxicity, adverse effects, and biosecurity. We also describe how conventional pain is managed and the possible use of compounds obtained from vegetable species for pain treatment.

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Psychoneuroimmunology of mental disorders

Cited by 25 publications

References 77 publications

Classification of patients with bipolar disorder using k-means clustering

Classification of patients with bipolar disorder using k-means clustering

Peer Review #2 of "A systematic review and realist synthesis on toilet paper hoarding: COVID or not COVID, that is the question (v0.2)"

Pharmaceutical and Botanical Management of Pain Associated with Psychopathology: A Narrative Review

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