2008
DOI: 10.4314/ijbcs.v2i3.39745
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Psychopharmacological properties of the saponin fraction of <i>Ficus platyphylla</i> stem bark

Abstract: The psychopharmacological effects of a saponin-rich fraction (SFG) obtained from crude methanolic extract of Ficus platyphylla stem bark were studied on spontaneous motor activity (SMA), pentobarbitalinduced sleep, motor coordination, amphetamine-induced hyperactivity and stereotyped behaviour, catalepsy, forced swim and tail suspension tests in rodents. SFG reduced SMA dose dependently, suggesting that it may contain psychoactive principles with sedative effects. The fraction shortened the onset and prolonged… Show more

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Cited by 8 publications
(7 citation statements)
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“…In our second set of experiments, apomorphine-induced hyperactivity was blocked by co-administration of 50 and 200 mg/kg FP or administration of clozapine. This finding supports our previous studies on the effects of FP on amphetamine-induced hyperactivity in mice [5]. Findings that gave an earlier clue on the anti-psychotic properties of FP, given that antipsychotics typically block hyperactivity induced by psychostimulants [20].…”
Section: Discussionsupporting
confidence: 87%
See 1 more Smart Citation
“…In our second set of experiments, apomorphine-induced hyperactivity was blocked by co-administration of 50 and 200 mg/kg FP or administration of clozapine. This finding supports our previous studies on the effects of FP on amphetamine-induced hyperactivity in mice [5]. Findings that gave an earlier clue on the anti-psychotic properties of FP, given that antipsychotics typically block hyperactivity induced by psychostimulants [20].…”
Section: Discussionsupporting
confidence: 87%
“…We have shown in our previous studies that FP reversed amphetamine-induced hyperactivity and stereotypy in mice [5] which suggested its neuroleptic-like effects.…”
Section: Introductionmentioning
confidence: 96%
“…21,22 A report of the psychopharmacological and anticonvulsant effects of the saponins rich fraction of this medicinal plant has also been revealed. 23 The present study is stem up from the previous studies showing this plant to have an anti-inflammatory which by extension could have antioxidant activities that may probably assist to protect the liver from pain and excessive damages.…”
mentioning
confidence: 99%
“…Since saponins, which form the major components of the crude methanol extract are believed to have analgesic and anti-inflammatory properties (Gupta at al., 1969;Adzu et al, 2003., Taesotiku et al, 2003Asongalem et al, 2004;Ojewole, 2008), we hypothesized that saponins may be involved in the analgesic and anti-inflammatory effects of the crude methanol extract earlier reported (Amos et al, 2002). Here, we evaluated the analgesic and anti-inflammatory properties of the saponin rich fraction as a step toward the isolation of biologically active components of extract of Ficus platyphylla and to complement earlier studies (Chindo et al, 2008;2009) on this medicinal plant, which is already in common use.…”
Section: Introductionmentioning
confidence: 85%