Liver serves as an important organ in the detoxification of various drugs and xenobiotics in the body and drug-induced liver diseases is said to accounts for about 50% of all hospital admissions and 50% of all acute liver failure resulting in the withdrawal of some approved drugs from the market. 1,2 The withdrawal of these drugs appears to be as a result of enormous toxicities arising from the liver such as unique vascular, secretory, synthetic and metabolic effects. 3 Excessive production of pro-oxidants and ROS in the liver can result in the damage of both structural and functional integrity of the liver cells amounting to widespread liver toxicities. 4 Antioxidants protect the human body against the damage caused by reactive oxygen species (ROS). 5 These ROS are produced in vivo through various biochemical reactions and respiratory chain coming from occasional leakage. 6 The leakages are the main agents in lipid peroxidation and several anti-inflammatory, digestive, anti-neurotic, neuroprotective, and hepatoprotective drugs have recently been shown to have antioxidant and/or radical scavenging activities. 7