Psychopharmacological treatment of disruptive behavior in youths: systematic review and network meta-analysis

Seok, Ji-Woo; Soltis-Vaughan, Brigette; Lew, Brandon J.; Ahmad, Aatiya; Blair, R. J. R.; Hwang, Soonjo

doi:10.1038/s41598-023-33979-2

Cited by 4 publications

(3 citation statements)

References 139 publications

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“…Efficacy-oriented systematic reviews, such as that conducted by de Pablo et al (2023), agree that risperidone and aripiprazole are efficacious as interventions for irritability and emotional dysregulation but, despite this, researchers emphasise that these medications can only comprise one element of a multicomponent intervention and are best prescribed for only short-term usage. Seok et al (2023) conducted a network meta-analysis of randomised control trials of the comparative efficacy of psychotropic medications prescribed to treat disruptive behaviour in young people (diagnoses included autism, ADHD, conduct disorder, disruptive behaviour disorder) and found that second-generation psychotropic medications with greater dopaminergic receptor affinity (e.g., risperidone) showed significant efficacy in reducing disruptive behaviour (Seok et al, 2023).…”

Section: Psychopharmacological Treatmentsmentioning

confidence: 99%

Current Status of Psychopharmacological, Neuromodulation, and Oxytocin Treatments for Autism: Implications for Clinical Practice

Bitsika,

Sharpley

2023

Adv Neurodev Disord

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Objectives To provide an overview of the current literature regarding the neurobiological treatments of psychopharmacology, neuromodulation, oxytocin therapy, and psychological resilience, as treatments for autism-related difficulties, and to distil the research findings from those treatments for everyday clinical application. Methods Instead of producing another specific systematic summary of the efficacy of these treatments, this review took an overview of each field of research, identified its key research findings, and evaluated the treatment-ready status of each of them in terms of their evidence base. From this information, a set of recommendations were derived for their clinical applications, so as to inform practice in the field. Results These treatments represent relatively recent and neurobiologically based approaches to the challenges of autism, and are in the development stage. Each treatment is promising, and has some evidential basis for its success, but all need further research to establish their evidence-based validity for everyday clinical usage. Conclusions While most of these treatments can be applied with caution, clinicians should acknowledge their restrictive benefits and costs, that are described herein. Within those caveats, each of these treatments should be considered as an emerging therapy that clinicians should consider utilising in appropriate settings and with specific cases.

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Section: Psychopharmacological Treatmentsmentioning

confidence: 99%

Current Status of Psychopharmacological, Neuromodulation, and Oxytocin Treatments for Autism: Implications for Clinical Practice

Bitsika,

Sharpley

2023

Adv Neurodev Disord

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“…Because psychotherapeutic interventions for excessive anger are helpful but do not work for everyone, appropriate physiological treatments can be brought to bear. Seok et al’s (2023) recent meta-analysis found that second generation antipsychotics like respiridol were more efficacious than stimulant and other medications in reducing angry aggression in youth. There are no comparative data on these agents for adults in whom clinically significant but milder outbursts can be controlled with the specific serotonin re-uptake inhibitor fluoxetine (R.…”

Section: Treatment Of Excessive Anger and Reactive Aggression: Psycho...mentioning

confidence: 99%

“…Because psychotherapeutic interventions for excessive anger are helpful but do not work for everyone, appropriate physiological treatments can be brought to bear. Seok et al's (2023) recent metaanalysis found that second generation antipsychotics like respiridol were more efficacious than stimulant and other medications in This document is copyrighted by the American Psychological Association or one of its allied publishers.…”

Section: Treatment Of Excessive Anger and Reactive Aggression: Psycho...mentioning

confidence: 99%

Are reactions to frustrative nonreward in other animals a model for human anger? Neurobehavioral implications and therapeutic applications.

Potegal

2023

Behavioral Neuroscience

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Anger is a powerful and mostly deleterious emotion that can impair an individual’s health and social relationships and that imposes considerable costs on society at large. It is a constituent of multiple psychopathologies, most notably intermittent explosive disorder. Excessive anger can drive injurious and even lethal reactive aggression. To understand its biobehavioral origins and develop appropriate therapeutic interventions, an animal model of human anger would be quite useful. The phenomena of aggression provoked by frustrative nonreward (FNR) in other animals, including species of fish, birds, and mammals, resemble those in people in whom it elicits subjectively experienced anger. The brief history presented here traces the original, overgeneralized frustration–aggression hypothesis for humans through to the discovery of operant schedule-induced attack in birds, rodents, and ourselves to the current status of FNR as a cross-species, transdiagnostic construct within the National Institute of Health Research Domain Criteria. Brain circuitry that is activated by frustration, generates felt anger and motivates reactive aggression includes discomfort reactions likely instantiated in the insula and cingulate gyrus of the salience network and reward expectancy/prediction error mediated by the ventral striatum and other structures. Caveats in establishing a paradigm for other animals that most closely matches FNR-induced anger in people include avoiding confounds with other aggression-provoking stimuli and situations, providing evidence for aggressive motivation, as well as behavior, and demonstrating activation of homologous brain structures. With appropriate regard for these caveats, developing such paradigms appears to be the best route to advancing psychopharmacological and deep brain stimulation treatments for excessive anger.

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Contemporary diagnosis and treatment of conduct disorder in youth

Masi,

Carucci,

Muratori

et al. 2023

Expert Review of Neurotherapeutics

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Psychopharmacological treatment of disruptive behavior in youths: systematic review and network meta-analysis

Cited by 4 publications

References 139 publications

Current Status of Psychopharmacological, Neuromodulation, and Oxytocin Treatments for Autism: Implications for Clinical Practice

Current Status of Psychopharmacological, Neuromodulation, and Oxytocin Treatments for Autism: Implications for Clinical Practice

Are reactions to frustrative nonreward in other animals a model for human anger? Neurobehavioral implications and therapeutic applications.

Contemporary diagnosis and treatment of conduct disorder in youth

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