Psychopharmacology of chronic pain

Ciaramella, Antonella

doi:10.1016/b978-0-444-64012-3.00019-8

Cited by 13 publications

(12 citation statements)

References 233 publications

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“…Brain imaging studies have demonstrated that various regions of the brain participate in the process of autonomous painful, affective, sensory, cognitive, motor, and inhibitory responses. This approach, the neuromatrix theory of pain, suggests that pain perception involves a nociceptive process and that chronic pain is the result of the activation of a complex neural network capable of generating rapid neuroplastic disturbances [ 18 ].…”

Section: Painmentioning

confidence: 99%

“…Neuroimaging studies have demonstrated that persistent pain is associated with morphological changes in corticolimbic regions because patients with persistent pain show reduced gray matter volume in the hippocampus and amygdala. This suggests that chronic pain is related to emotional and cognitive changes [ 18 ]. Thus, changes in connectivity between the mPFC and NAs influence the perception of pain.…”

Section: Neural Pathway Between Depression and Painmentioning

confidence: 99%

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Depression and Pain: Use of Antidepressants

Bonilla-Jaime

Sánchez-Salcedo

Estévez-Cabrera

et al. 2022

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Background: Emotional disorders are common comorbid affectations that exacerbate the severity and persistence of chronic pain. Specifically, depressive symptoms can lead to an excessive duration and intensity of pain. The use of antidepressant drugs is associated with pain reduction. The recent development of animal models has accelerated studies focusing on the underlying mechanisms of chronic pain and depression comorbidity. Aim: This review provides an overview of the comorbid relationship of chronic pain and depression, the clinical and pre-clinical studies performed on the neurobiological aspects of pain and depression, and the use of antidepressants as analgesics. Method: A systematic search of literature databases was conducted according to the pre-defined criteria. The authors independently conducted a focused analysis of the full-text articles. Results: Studies suggest that pain and depression are highly-intertwined and may co-exacerbate physical and psychological symptoms. One important biochemical basis for pain and depression focuses on the serotonergic and norepinephrine system, which have been shown to play an important role in this comorbidity. Brain structures that codify pain are also involved in mood. It is evident that using serotonergic and norepinephrine antidepressants are strategies commonly employed to mitigate pain. Conclusion: Literature indicates that pain and depression impact each other and play a prominent role in the development and maintenance of other chronic symptoms. Antidepressants continue to be a major therapeutic tool for managing chronic pain. Tricyclic antidepressants (TCAs) are more effective in reducing pain than selective serotonin reuptake inhibitors (SSRIs) and serotonin-noradrenaline reuptake inhibitors (SNRIs).

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Section: Painmentioning

confidence: 99%

Section: Neural Pathway Between Depression and Painmentioning

confidence: 99%

Depression and Pain: Use of Antidepressants

Bonilla-Jaime

Sánchez-Salcedo

Estévez-Cabrera

et al. 2022

View full text Add to dashboard Cite

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“…Although almost all branches of medicine, especially neurology, physical medicine and rehabilitation, family medicine, and urology benefit from the developments in psychopharmacology [37][38][39][40][41]; expectations from these developments, and its applications to the practice remain mainly to be the field of psychiatry. Research shows that the applications made to psychiatry outpatient clinics also include illnesses, personality and relationship problems whose diagnosis and treatment algorithms are not well established [42,43].…”

Section: Psychotherapeutic Intervention and Therapeutic Relationshipmentioning

confidence: 99%

From Psychiatric Interviews to Psychotherapies

Göka¹,

Batuhan²,

Çisil³

2021

Int J Psychol Psychoanal

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Psychotherapy can be defined as a treatment method consisting of psychological tools whereby a trained expert works with a person or a group to resolve the patient's biopsychosocial problems through relation and communication.This paper aims to create a look into the use of psychotherapies within the current psychiatric and medical notions and seek to emphasize that a new concept such as "psychotherapeutic intervention" is needed to overcome the contradiction mentioned above or that this concept needs to be revived and its

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“…Chronic pain (CP) usually develops from the acute to a chronic state ( 1 ) and persists after expected healing, or exists in the absence of tissue damage, as a result of complex neural network interactions ( 2 ). Chronic pain, including neuropathic pain, chronic inflammatory pain, cancer pain, etc., has more complex clinical manifestations than acute pain.…”

Section: Introductionmentioning

confidence: 99%

Potential Neuroimmune Interaction in Chronic Pain: A Review on Immune Cells in Peripheral and Central Sensitization

Jiang¹,

Wang

Chen³

et al. 2022

Front. Pain Res.

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Chronic pain is a long-standing unpleasant sensory and emotional feeling that has a tremendous impact on the physiological functions of the body, manifesting itself as a dysfunction of the nervous system, which can occur with peripheral and central sensitization. Many recent studies have shown that a variety of common immune cells in the immune system are involved in chronic pain by acting on the peripheral or central nervous system, especially in the autoimmune diseases. This article reviews the mechanisms of regulation of the sensory nervous system by neutrophils, macrophages, mast cells, B cells, T cells, and central glial cells. In addition, we discuss in more detail the influence of each immune cell on the initiation, maintenance, and resolution of chronic pain. Neutrophils, macrophages, and mast cells as intrinsic immune cells can induce the transition from acute to chronic pain and its maintenance; B cells and T cells as adaptive immune cells are mainly involved in the initiation of chronic pain, and T cells also contribute to the resolution of it; the role of glial cells in the nervous system can be extended to the beginning and end of chronic pain. This article aims to promote the understanding of the neuroimmune mechanisms of chronic pain, and to provide new therapeutic ideas and strategies for the control of chronic pain at the immune cellular level.

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Psychopharmacology of chronic pain

Cited by 13 publications

References 233 publications

Depression and Pain: Use of Antidepressants

Depression and Pain: Use of Antidepressants

From Psychiatric Interviews to Psychotherapies

Potential Neuroimmune Interaction in Chronic Pain: A Review on Immune Cells in Peripheral and Central Sensitization

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