Psychophysiological correlates of cognitive deficits in family caregivers of patients with Alzheimer Disease

Corrêa, M.S.; Vedovelli, Kelem; Giacobbo, Bruno Lima; Souza, C.E.B. de; Ferrari, P.; Argimon, Irani Iracema de Lima; Walz, Julio Cesar; Kapczinski, Flávio; Bromberg, Elke

doi:10.1016/j.neuroscience.2014.11.052

Cited by 59 publications

(58 citation statements)

References 118 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Indeed, high incidence rates of depression and anxiety have been documented in this population of caregivers (Kuusikko‐Gauffin et al, ; van Steijn, Oerlemans, van Aken, Buitelaar, & Rommelse, ). In addition to psychological effects, parents of children with ASD may experience a number of changes in various physiological systems that may lead to health impairments, as observed in other populations of caregivers (Corrêa et al, ). The polyvagal theory has indeed proposed a theoretical model to explain the coexistence of dysregulated physiological systems in psychiatric and behavioural disorders characterized by difficulties in regulating appropriate social, emotional, and communication behaviours (Porges, ).…”

Section: Introductionmentioning

confidence: 99%

Psychological characteristics and physiological reactivity to acute stress in mothers of children with autism spectrum disorder

Pattini¹,

Carnevali

Troisi

et al. 2019

Stress and Health

View full text Add to dashboard Cite

Stress related to parenting a child with autism spectrum disorder can differently affect caregiver's physiological reactivity to acute stress. Here, parental stress levels, psychological characteristics, and coping strategies were assessed alongside measures of heart rate, heart rate variability, and cortisol during a psychosocial stress test in mothers of children with ASD (M-ASD, n = 15) and mothers of typically developing children (n = 15). M-ASD reported significantly higher levels of parental stress, anxiety, negative affectivity, social inhibition, and a larger preference for avoidance strategies. M-ASD showed larger heart rate and cortisol responses to the psychosocial stress test. A positive relationship was found between parental stress levels and the magnitude of the cortisol stress response in both groups. The present findings indicate exaggerated physiological reactivity to acute psychosocial stress in M-ASD and prompt further research to explore the role of individual differences in mediating the effects of parental stress on physiological stress responses.

show abstract

Section: Introductionmentioning

confidence: 99%

Psychological characteristics and physiological reactivity to acute stress in mothers of children with autism spectrum disorder

Pattini¹,

Carnevali

Troisi

et al. 2019

Stress and Health

View full text Add to dashboard Cite

show abstract

“…In this respect, cortisol can also be measured in saliva linking to stress/anxiety and depression as opposed to well-being, risks and protectors, res p e c t i v e l y i n t e r m s o f A D [ 3 7 ] . F u r t h e r m o r e , Dehydroepiandrosterone (DHEA) can be measured as well and correlated with cortisol [38].…”

Section: Saliva Biomarkersmentioning

confidence: 99%

Specific protein biomarker patterns for Alzheimer’s disease: improved diagnostics in progress

Gozes

2017

EPMA Journal

View full text Add to dashboard Cite

This short review looks at Alzheimer's disease (AD) diagnosis through my own point of view, going from imaging through cerebrospinal fluid to blood proteins. Over the last couple of years, we have published two papers targeted at Alzheimer's diagnosis. In one paper, we took an approach of selecting a specific target, namely, activitydependent neuroprotective protein (ADNP), and our results tightened the association of ADNP blood expression with intelligence. In another paper, we took an unbiased approach of analysis of all genes expressed in lymphoblastoid cells lines and discovered changes in expression of the regulator of G-protein signaling 2 (RGS2) as a potential AD predictor. This review will assess our data in comparison to selected independent studies focusing on blood protein biomarkers as well as assessing saliva and urine samples with potential predictive value for AD. Furthermore, the review will provide directions for a combination of innovative markers, stratifying the population toward disease prevention and personalized medicine.

show abstract

“…27,[29][30][31][32] Alzheimer hastasına bakım veren bireylerin anksiyete, uyku bozuklukları, tükenmişlik, depresyon, kronik stres ve bununla ilişkili bellek sorunları yaşadıkları, yaşam kalitelerinin ve genel sağlık durumlarının olumsuz olarak etkilendiği bildirilmiştir. 30,[33][34][35] Bir meta-analiz çalış-masında, bunama hastasına bakım veren yakın-larında sempatik aşırı aktivasyonun geliştiği ve hipertansiyon, kardiyovasküler hastalıklar, kronik inflamatuvar hastalıklar gibi psikosomatik hastalıkların sık görüldüğü belirlenmiştir. 36 Çalış-mamızın karşılaştırma grubu yoktur, ancak sonuçlarımız bakım veren hasta yakınlarında depresyon ve anksiyete belirtilerinin normalin üzerinde olduğunu göstermektedir.…”

Section: Introductionunclassified

Psychodramatic group therapy on Alzheimer patients' caregiver relatives

Varma¹,

Oğuzhanoğlu²,

Ateşçi³

et al. 2018

Anadolu Psikiyatri Derg

View full text Add to dashboard Cite

show abstract

Psychophysiological correlates of cognitive deficits in family caregivers of patients with Alzheimer Disease

Cited by 59 publications

References 118 publications

Psychological characteristics and physiological reactivity to acute stress in mothers of children with autism spectrum disorder

Psychological characteristics and physiological reactivity to acute stress in mothers of children with autism spectrum disorder

Specific protein biomarker patterns for Alzheimer’s disease: improved diagnostics in progress

Psychodramatic group therapy on Alzheimer patients' caregiver relatives

Contact Info

Product

Resources

About