“…The annual direct and indirect monetary burden of TBI on the United States was estimated at $60 billion in 2000 (Finkelstein et al, 2006). Survivors of TBI have a reduced QOL, as assessed by multiple scales, including the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36), the Sickness Impact Profile and the General Health Questionnaire, the Life Satisfaction Inventory, and the newlydeveloped Quality of Life in TBI or QOLIBRI scale (Colantonio et al, 1998;Corrigan et al, 1998;Findler et al, 2001;Guilfoyle et al, 2010;Kinsella et al, 1989;Kreuter et al, 1998;O'Carroll et al, 1991;Paniak et al, 1999;Resch et al, 2009;Temkin et al 1988;Truelle et al, 2010). There has been a call for increased utilization of CER to improve these statistics, though such studies in the TBI field have heretofore been limited due to the lack of QOL values for comparing intermediate outcomes as described by the GOSE.…”