Psychosis associated behavioral and psychological signs and symptoms in mild cognitive impairment and Alzheimer's dementia

Mussele, Stefan Van der; Mariën, Peter; Saerens, J.; Somers, Nore; Goeman, Johan; Deyn, Peter Paul De; Engelborghs, Sebastiaan

doi:10.1080/13607863.2014.967170

Cited by 24 publications

(14 citation statements)

References 44 publications

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“…Of note, a recent study in a Belgian cohort of patients with MCI and AD found that psychosis-related symptoms (such as delusions or hallucinations) were present in up to 40% of patients with AD. 16 In patient DR1090, the onset of memory problems was also preceded by mild parkinsonian features, which remained stable during the disease course under an unchanging dose of levodopa. A consensus diagnosis of AD was made, although the possibility of a concomitant Lewy body pathology could not be excluded.…”

Section: Discussionmentioning

confidence: 96%

Phenotypic characteristics of Alzheimer patients carrying an ABCA7 mutation

et al. 2016

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Objective:To generate a clinical and pathologic phenotype of patients carrying rare loss-of-function mutations in ABCA7, identified in a Belgian Alzheimer patient cohort and in an autosomal dominant family.Methods:We performed a retrospective review of available data records, medical records, results of CSF analyses and neuroimaging studies, and neuropathology data.Results:The mean onset age of the mutation carriers (n = 22) was 73.4 ± 8.4 years with a wide age range of 36 (54–90) years, which was independent of APOE genotype and cerebrovascular disease. The mean disease duration was 5.7 ± 3.0 years (range 2–12 years). A positive family history was recorded for 10 carriers (45.5%). All patient carriers except one presented with memory complaints. The 4 autopsied brains showed typical immunohistochemical changes of late-onset Alzheimer disease.Conclusions:All patients carrying a loss-of-function mutation in ABCA7 exhibited a classical Alzheimer disease phenotype, though with a striking wide onset age range, suggesting the influence of unknown modifying factors.

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Section: Discussionmentioning

confidence: 96%

Phenotypic characteristics of Alzheimer patients carrying an ABCA7 mutation

et al. 2016

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“…This may restrict the representativeness of our findings, as such symptoms are relatively common in patients with dementia or MCI. 23 We believe that our results, using a simple and widely available task-oriented test, are sensitive to detect motor deficits in these populations. However, these results should be replicated in a longitudinal design.…”

Section: Discussionmentioning

confidence: 99%

Impairment of fine motor dexterity in mild cognitive impairment and Alzheimer’s disease dementia: association with activities of daily living

Paula

Albuquerque

Lage

et al. 2016

Rev. Bras. Psiquiatr.

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Objective: Cognitive impairment is a hallmark of mild cognitive impairment (MCI) and Alzheimer's disease dementia (AD). Although the cognitive profile of these patients and its association with activities of daily living (ADLs) is well documented, few studies have assessed deficits in fine motor dexterity and their association with ADL performance. The objective of this research paper is to evaluate fine motor dexterity performance among MCI and AD patients and to investigate its association with different aspects of ADLs. Methods: We assessed normal aging controls, patients with multiple-and single-domain amnestic MCI (aMCI), and patients with mild AD. Fine motor dexterity was measured with the Nine-Hole Peg Test and cognitive functioning by the Mattis Dementia Rating Scale. We analyzed the data using general linear models. Results: Patients with AD or multiple-domain aMCI had slower motor responses when compared to controls. AD patients were slower than those with single-domain aMCI. We found associations between cognition and instrumental ADLs, and between fine motor dexterity and self-care ADLs. Conclusion: We observed progressive slowing of fine motor dexterity along the normal aging-MCI-AD spectrum, which was associated with autonomy in self-care ADLs.

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“…Psychotic symptoms, such as hallucinations and paranoid/delusional ideation have been reported in up to 45% of the non-DS AD patients -delusions being generally more common than hallucinations (Eustace et al, 2002;Gauthier et al, 2010;Mega et al, 1996;Van der Mussele, Mariën, et al, 2014b). Using the BEHAVEAD, Temple & Konstantareas (2005) studied BPSD in AD patients with DS (DS-AD) and without (AD-only).…”

Section: Psychosis Hallucinations Paranoia and Delusionsmentioning

confidence: 99%

Behavioural and psychological symptoms of dementia in Down syndrome: Early indicators of clinical Alzheimer's disease?

Dekker

Strydom

Coppus

et al. 2015

Cortex

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Behavioural and Psychological Symptoms of Dementia (BPSD) are a core symptom of dementia and are associated with suffering, earlier institutionalization and accelerated cognitive decline for patients and increased caregiver burden. Despite the extremely high risk for Down syndrome (DS) individuals to develop dementia due to Alzheimer's disease (AD), BPSD have not been comprehensively assessed in the DS population. Due to the great variety of DS cohorts, diagnostic methodologies, sub-optimal scales, covariates and outcome measures, it is questionable whether BPSD have always been accurately assessed. However, accurate recognition of BPSD may increase awareness and understanding of these behavioural aberrations, thus enabling adaptive caregiving and, importantly, allowing for therapeutic interventions. Particular BPSD can be observed (long) before the clinical dementia diagnosis and could therefore serve as early indicators of those at risk, and provide a new, non-invasive way to monitor, or at least give an indication of, the complex progression to dementia in DS. Therefore, this review summarizes and evaluates the rather limited knowledge on BPSD in DS and highlights its importance and potential for daily clinical practice.

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Psychosis associated behavioral and psychological signs and symptoms in mild cognitive impairment and Alzheimer's dementia

Abstract: AD patients clearly display psychosis associated BPSD, whereas MCI patients only display more severe frontal lobe symptoms and physically non-aggressive agitated behavior, but also less pronounced than in AD.

Cited by 24 publications

References 44 publications

Phenotypic characteristics of Alzheimer patients carrying an ABCA7 mutation

Phenotypic characteristics of Alzheimer patients carrying an ABCA7 mutation

Impairment of fine motor dexterity in mild cognitive impairment and Alzheimer’s disease dementia: association with activities of daily living

Behavioural and psychological symptoms of dementia in Down syndrome: Early indicators of clinical Alzheimer's disease?

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