Psychosis associated with usage of herbal slimming products adulterated with sibutramine: a case series

Chen, Sammy P L; Tang, Magdalene Huen Yin; Ng, Sau Wah; Poon, Wing-Tat; Chan, Andrew; Mak, Tony Wing Lai

doi:10.3109/15563650.2010.517208

Cited by 29 publications

(19 citation statements)

References 16 publications

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“…It has already spread to another life-style drug (sibutramine) and might as well spread to essential drugs [100][101][102]. Proactive regulation of all possible analogues of registered ED drug substances may be useful.…”

Section: Discussionmentioning

confidence: 98%

Towards a decade of detecting new analogues of sildenafil, tadalafil and vardenafil in food supplements: A history, analytical aspects and health risks

Venhuis

Kaste

2012

Journal of Pharmaceutical and Biomedical Analysis

158

116

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Section: Discussionmentioning

confidence: 98%

Towards a decade of detecting new analogues of sildenafil, tadalafil and vardenafil in food supplements: A history, analytical aspects and health risks

Venhuis

Kaste

2012

Journal of Pharmaceutical and Biomedical Analysis

158

116

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“…[165] Among the 62 samples that tested positive, 25 contained sibutramine, desmethylsibutramine, and didesmethylsibutramine as well as other weight loss compounds. [166] Sibutramine was detected and quantified by GC-MS in five slimming food samples collected in China. [165] A series of 17 cases of documented poisonings in Germany from 2005 to 2008 revealed that sibutramine-containing products were involved in all of the cases.…”

Section: Drug Testing and Analysismentioning

confidence: 99%

Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs)

Pawar

Grundel

2016

Drug Testing and Analysis

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The multi-billion dollar dietary supplement industry is global in reach. The industry has been criticized for problems related to poor quality control, safety, misbranding, and adulteration. In this review, we describe how the US Food and Drug Administration (FDA) regulates dietary supplements within the framework of the Federal Food, Drug, and Cosmetic Act (FD&C Act). The Dietary Supplement Health and Education Act of 1994 (DSHEA), which amended the FD&C Act, gave the FDA the authority to promulgate Good Manufacturing Practices for dietary supplements and required that manufacturers provide the FDA information supporting a conclusion that the ingredients are reasonably expected to be safe if the dietary ingredients were not marketed in the USA before 15 October 1994. Recent amendments to the FD&C Act require that serious dietary-supplement-related adverse events be reported to the FDA and provide the agency with mandatory recall authority. We discuss the presence of naturally occurring (e.g. Ephedra, Citrus aurantium, Acacia) and synthetic (e.g. β-methylphenethylamines, methylsynephrine, α-ethyl-phenethylamine) biologically active phenethylamines (PEAs) in dietary supplements and of PEA drugs (e.g. clenbuterol, fenfluramine, sibutramine, lorcaserin) in weight-loss products. Regulatory actions against manufacturers of products labelled as dietary supplements that contain the aliphatic amines 1,3-dimethylamine and 1,3-dimethylbutylamine, and PEAs such as β-methylphenethylamine, aegeline, and Dendrobium illustrate the FDA's use of its authority under the FD&C Act to promote dietary supplement safety. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.

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“…Bu olgularda halsizlik, bulantı-kusma, ağız kuruluğu, konstipasyon, uykusuzluk, ajitasyon, baş ağrısı, halüsinasyon, taşikardi, hipertansiyon, dispne, ateş bildirilmiştir. [14][15][16] Olgumuzun kullandığı ürünün içeriği tarafımızdan tetkik edilememiş olmakla beraber taşikardi ve hipertansiyon gözlenmesi ürünün içinde sibutramin olabileceğini düşündürmektedir.…”

Section: Olgu Sunumuunclassified

Suicide attempt with herbal weight loss product: A adolescent patient

Zengın¹,

Can²,

Can³

et al. 2015

Turk J Ped Em Int Care Med

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Psychosis associated with usage of herbal slimming products adulterated with sibutramine: a case series

Cited by 29 publications

References 16 publications

Towards a decade of detecting new analogues of sildenafil, tadalafil and vardenafil in food supplements: A history, analytical aspects and health risks

Towards a decade of detecting new analogues of sildenafil, tadalafil and vardenafil in food supplements: A history, analytical aspects and health risks

Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs)

Suicide attempt with herbal weight loss product: A adolescent patient

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