Psychosis may be associated with toxoplasmosis

Zhu, Sha

doi:10.1016/j.mehy.2009.04.013

Cited by 55 publications

(59 citation statements)

References 20 publications

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“…The parasite T. gondii has received increasing attention in the last years especially due to behavioral and neurological changes observed in rodents and humans [16][17][18][19][20][21][22][26][27][28][29][30]. Prompted on revealing the mechanisms used by the parasite to contribute to neurological and psychiatric disorders, research focused mainly on pathological changes in the brain affected by the infection.…”

Section: Discussionmentioning

confidence: 99%

“…While infection with T. gondii has long time been considered asymptomatic in immunocompetent hosts, this view is challenged by recent reports describing the link between seropositivity and behavioral, personality and neuropsychiatric disorders [16][17][18][19][20][21][22]. Interestingly, subtle motor impairment, in the form of prolonged reaction time, was reported in seropositive but otherwise healthy individuals [17,[23][24][25].…”

Section: Introductionmentioning

confidence: 99%

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Spinal cord pathology in chronic experimentalToxoplasma gondiiinfection

Möhle¹,

Parlog²,

Pahnke³

et al. 2014

European Journal of Microbiology and Immunology

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Infection with the protozoan Toxoplasma (T.) gondii causes chronic infection of the central nervous system and can lead to lifethreatening encephalomyelitis in immunocompromised patients. While infection with T. gondii has long time been considered asymptomatic in immunocompetent hosts, this view is challenged by recent reports describing links between seropositivity and behavioral alterations.However, past and current researches are mainly focused on the brain during Toxoplasma encephalitis, neglecting the spinal cord as a key structure conveying brain signals into motion. Therefore, our study aimed to fill the gap and describes the spinal cord pathology in an experimental murine model of toxoplasmosis.In the spinal cord, we found distinct histopathological changes, inflammatory foci and T. gondii cysts similar to the brain. Furthermore, the recruitment of immune cells from the periphery was detected. Moreover, resident microglia as well as recruited monocytes displayed an increased MHC classes I and II expression. Additionally, the expression of pro-and anti-inflammatory cytokines was enhanced in the brain as well as in the spinal cord. In summary, the pathology observed in the spinal cord was similar to the previously described changes in the brain during the infection.This study provides the first detailed description of histopathological and immunological alterations due to experimental T. gondii induced myelitis in mice. Thus, our comparison raises awareness of the importance of the spinal cord in chronic T. gondii infection.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Spinal cord pathology in chronic experimentalToxoplasma gondiiinfection

Möhle¹,

Parlog²,

Pahnke³

et al. 2014

European Journal of Microbiology and Immunology

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“…Zhu 33) suggested that psychosis might be associated with T. gondii infection, and the potential mechanism of T. gondii infection in behavioral change may be through its direct effect on neuronal function and immune-mediated dopamine and serotonin synthesis.…”

Section: Discussionmentioning

confidence: 99%

The association between suicide attempts and Toxoplasma gondii infection

Shim¹,

Jung²,

Yang³

et al. 2017

European Neuropsychopharmacology

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“…In particular, several epidemiological, behavioral, and neurochemical studies suggested the existence of an association between schizophrenia and past history of infection by T. gondii (da Silva and Langoni, 2009;Dion et al, 2009;Gaskell et al, 2009;Xiao et al, 2009;Yolken et al, 2009;Zhu, 2009). …”

Section: Humansmentioning

confidence: 99%

Toxoplasma in Animals, Food, and Humans: An Old Parasite of New Concern

Cenci‐Goga

Rossitto

Sechi

et al. 2011

Foodborne Pathogens and Disease

142

106

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All hosts, including humans, can be infected by any one of the three forms of the parasite Toxoplasma gondii that correspond to three morphological stages: tachyzoite, bradyzoite, and sporozoite form. Felids are definitive hosts for T. gondii, which is an intracellular pathogen that infects a wide range of warm-blooded intermediate hosts. Toxoplasmosis is a disease where the interest of the diverse medical and veterinary specialties converge. Awareness needs to be increased that toxoplasmosis can induce clinical disease not only in immunocompromised patients or through congenital infections, but also in healthy patients. This is a review article that aims at illustrating why toxoplasmosis should be regarded a veterinary public health issue and how veterinary practitioners can contribute in controlling the infection.

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Psychosis may be associated with toxoplasmosis

Cited by 55 publications

References 20 publications

Spinal cord pathology in chronic experimentalToxoplasma gondiiinfection

Spinal cord pathology in chronic experimentalToxoplasma gondiiinfection

The association between suicide attempts and Toxoplasma gondii infection

Toxoplasma in Animals, Food, and Humans: An Old Parasite of New Concern

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