Psychosocial factors and coronary heart disease

Kubareva, M I; Ibatov, A D

doi:10.26442/00403660.2019.12.000086

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…Despite the occurrence of brilliant advances in the field of prevention and treatment, coronary heart disease (CHD) is still known as the most common cause of death throughout the world. Altho ugh it is not possible to precisely recognize the patients at risk of developing coronary artery disease (CAD), influences of certain risk factors, genetic and environmental, have been quite understood (1,2). The most familiar risk factors include aging, hypertension, diabetes mellitus (DM), smoking, lack of physical activity, mental stress, obesity, and being overweight.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Calcium Score and Conventional Risk Factors in the Diagnosis of Atherosclerosis

Yazdi

Fariba

Karimian

et al. 2022

Med. J. Islam. Republ. Iran

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Section: Introductionmentioning

confidence: 99%

Relationship between Calcium Score and Conventional Risk Factors in the Diagnosis of Atherosclerosis

Yazdi

Fariba

Karimian

et al. 2022

Med. J. Islam. Republ. Iran

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“…Previous researches have shown that the incidence rate of CHD is different from men to women, and the prognosis of female is worse than that of male [5,6]. In addition, there are many factors associated with CHD, such as psychological stress, work-related stress, lifestyle and so on [7][8][9][10]. CHD is usually prevented and treated by normalization of blood lipid pro le, hypertension control, nutritional supplements in clinic [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

A Multi-Scale Bioinformatics Study on Novel Mechanism of Xintong Granule for Treating Coronary Heart Disease by Network Pharmacology and Molecular Docking Verification

Huang¹,

Guo²,

Fu³

et al. 2020

Preprint

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Background: Xintong Granule (XTG) is a Chinese patent medicine composed of 13 Chinese herbs, which is widely used in the treatment of coronary heart disease (CHD). However, there are few studies on it, and its potential pharmacological mechanism needs to be further elucidated.Methods: In this study, network pharmacology was employed to construct the drug-compounds-targets-pathways molecular regulatory network of the treatment of CHD to explore the effective compounds of XTG and its underlying pharmacological mechanism. First, we established the related ingredients and potential targets of these ingredients databases by Traditional Chinese Medicine Systems Pharmacology Database (TCMSP) and A Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine (BATMAN-TCM). Next, the CHD targets were obtained in DigSee, OMIM, DisGeNET, TTD, GeneCards and GenCLiP3 database. Then, protein-protein interaction (PPI) analysis, GO and KEGG pathway enrichment analysis were carried out and the core targets were filtered by topology. Moreover, molecular docking was performed to assess the binding potential of hub targets and key compounds.Results: The result reflected that 178 components of XTG and 669 putative therapeutic targets were screened out. After a systematic and comprehensive analysis, we identified 9 hub targets (TNF, MAPK1, STAT3, IL6, AKT1, INS, EGFR, EGF, TP53) primarily participated in the comprehensive therapeutic effect related to blood circulation, vascular regulation, cell membrane region, compound binding, receptor activity, signal transduction, AGE-RAGE signaling pathway in diabetic complications, JAK-STAT signaling pathway, PI3K-AKT signaling pathway and MAPK signaling pathway.Conclusion: The results of this study tentatively clarified the potential targets and signaling pathways of XTG against CHD, which may benefit to the development of clinical experimental research and application.

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Depressive disorders and quality of live in patients with acute coronary syndrome in real clinical practice

et al. 2022

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Objective. To study the prevalence of depressive disorders using Zung Self-rating Depression Scale (SDS) in patients with acute coronary syndrome (ACS) in the daily work of the Regional Vascular Center in various gender and social subgroups and to compare their severity with the life quality level.Materials and Methods. The survey included 116 (57 female and 59 male) patients, admitted to Regional Vascular Center with ACS from March to November 2020 (Group 1), and 49 patients hospitalized with other cardiological pathology (Group 2), who made up a comparison group comparable in gender, age, presence of diabetes mellitus, heart attack and stroke in anamnesis.Results. In Group I the score on SDS was higher or equal to 50 (depression) in 18 % of cases: 15 % female and 3 % male patients (p <0.05). The average score on SDS was notably higher in women than in men (p <0.05). In Group 2 depression was detected in 27 % of cases, without gender differences. The average level of depression was higher in older age groups, both in men and women, in patients with ACS and without ACS. A negative correlation was established for the indicators of SDS and SF-36: in Group 1 r = –0.62, p <0.05, in Group 2 r = –0.76, p <0.05. In Group 1 indicators of health physical component (SF-36) among women were: physical functioning 50, role functioning 34, general health 51, in men: 80, 58 and 63 respectively (p <0.05). In Group 2 these indicators significantly differed only in physical functioning: 60 female and 72 male. In Group 1 depression was observed in 2 % of working and in 30 % of non-working patients (p <0.05); in Group 2: 0 and 34 % respectively. In Groups 1 and 2 depression was found in 10 and 5 % among married, in 31 and 43 % among unmarried patients (p <0.05). In Group 1 depression was detected in 31 % among patients with diabetes, in 12 % – without diabetes (p <0.05). The other analyzed diseases did not have a significant effect on the de pression score.Conclusions. The presence of ACS was associated with depressive disorders in women. At the same time, the severity of depressive disorders was inversely correlated with the quality of life. In women with ACS, the physical component and the psychological component of health on the quality of life scale are significantly lower in comparison with men. In addition, the absence of work and marriage negatively affected the prevalence of depressive disorders among all examined patients. And the presence of diabetes mellitus was associated with a higher level of depression among patients with ACS. It is necessary to develop and implement specialized rehabilitation programs for the following subgroups of patients with ACS and depression – unemployed and unmarried women, with a low level of quality of life, elderly patients, patients with diabetes mellitus.

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Psychosocial factors and coronary heart disease

Cited by 4 publications

References 26 publications

Relationship between Calcium Score and Conventional Risk Factors in the Diagnosis of Atherosclerosis

Relationship between Calcium Score and Conventional Risk Factors in the Diagnosis of Atherosclerosis

A Multi-Scale Bioinformatics Study on Novel Mechanism of Xintong Granule for Treating Coronary Heart Disease by Network Pharmacology and Molecular Docking Verification

Depressive disorders and quality of live in patients with acute coronary syndrome in real clinical practice

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