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Background and Objective: Cardiovascular patients are susceptible to drug interactions due to the simultaneous use of several drug types. The purpose of this descriptive-analytic study was to evaluate the potential drug interactions and the related factors in subjects admitted to the Cardiology Department of Farshchian heart hospital of Hamadan, Iran. Materials and Methods: This descriptive cross-sectional study was conducted on 900 subjects. The data, including drugs, sex, type of illness, and length of hospitalization were extracted from files of the patients referred to Farshchian hospital in 2014 and 2015. Drug interactions were evaluated by the Micromedex 1630. The results were analyzed using SPSS software (version 16). Results: Of the 900 cases, 424 (47.1%) were male and 476 (52.9%) were female. A total of 4318 cases of interference were detected, 1610 (37.3%) of which were strongly interfered and 2708 (62.7%) were moderately interfered. The mean ages of males and females were 61.00 and 60.50 years, respectively (P=0.602). It was reported that 815 (90.6%) cases had at least one interaction. Based on the results, 389 male patients (91.3%) and 426 (90.6%) female patients had a drug interaction (P= 0.258). The differences of mean age, number of drugs, and length of hospitalization were statistically significant between the groups with and without interactions (P=0.001). The highest frequency of drug-drug interaction was detected with moderate severity in atrovastatin and clopidogrel with 464 repetition times. Furthermore, aspirin and clopidogrel with major severity and 485 repetitions were reported the most interfering drugs. Conclusion: Based on the results of this study, the amount of drug intake, length of hospitalization, and sex affect the incidence of drug interactions.

Introduction: Vitamin D deficiency is a major public health problem. Low vitamin D levels associated with adverse health consequences such as musculoskeletal health, cognitive decline and progression of cancer and death. The lack of vitamin D associated with major risk factors for cardiovascular disease (CVD) includes hypertension is considered. The ability to assess the general health, disease and treatment outcomes through saliva as a non-invasive, inexpensive and simple method of interest is located. The aim of this study was a comparative study of salivary and serum levels of vitamin D3 in patients with a history of developing high blood pressure and a healthy person.Methods: This study was a case - control survey, in which 40 patients with high blood pressure were examined. The control group including 40 healthy subjects. Both groups were matched in terms of age and gender. After collecting samples of serum and saliva, the amount of vitamin D level samples were measured using ELISA method by electrochemiluminescence (ELC), and then analyzed the results using software SPSS 16 and statistical test including Chi Square Test, Independent-Samples, linear regression model, the Mann-Whitney Test and Spearman correlation coefficient.Results: There was no significant difference in the mean serum levels of vitamin D among patients and healthy subjects (p= 0.588). In addition, there was no significant difference in the mean salivary levels of vitamin D between patients and healthy subjects (p= 0.833). There was no significant relationship between salivary and serum level of vitamin D in healthy individuals (p= 0.095). As well as there was no significant correlation between salivary and serum level of vitamin D in patients (p= 0.5).Conclusions: This study showed that vitamin D is a measurable marker in saliva, but its analysis in saliva, may not be a reliable tool for determining the vitamin D levels.