The association between congenital heart disease and the risk of Autism spectrum disorders or attention-deficit/hyperactivity disorder among children: a meta-analysis

Jenabi, Ensiyeh; Bashirian, Saeed; Fariba, Farnaz; Naghshtabrizi, B.

doi:10.1016/j.ejpsy.2021.10.001

Cited by 10 publications

(8 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Until now, only one existing meta‐analysis (Jenabi et al, 2022) has evaluated the association between CHD and ADHD. This meta‐analysis searched three databases through December 2020 and included five studies assessing the risk of ADHD in people with CHD.…”

Section: Discussionmentioning

confidence: 99%

The risk of attention‐deficit hyperactivity disorder among children with congenital heart disease: A systematic review and meta‐analysis

Tang,

Ou,

Chen

et al. 2023

Child

View full text Add to dashboard Cite

BackgroundAlthough current treatments are effective in dealing with congenital heart disease (CHD), non‐cardiac comorbidities such as attention‐deficit hyperactivity disorder (ADHD) have received widespread attention. The purpose of this systematic review and meta‐analysis is to assess the risk of ADHD associated with CHD.MethodsThe literature search was carried out systematically through eight different databases by the end of September 2022. Either a fixed‐ or a random‐effects model was used to calculate the overall combined risk estimates. The heterogeneity of the studies was assessed by the Cochran Q test and the I2 statistic. Subgroup and sensitivity analyses were used to explore the potential sources of heterogeneity.ResultsEleven studies were included in this study, which involved a total of 296 741 participants. Our study showed that the children with CHD were at a significantly increased risk of ADHD compared with the reference group (OR = 2.98, 95% CI: 2.18–4.08). The results were moderately heterogeneous. These factors including study design, geographic region and study quality were identified as the first three of the most relevant heterogeneity moderators by subgroup analyses. Sensitivity analysis yielded consistent results. There was no evidence of publication bias.ConclusionsThe present study suggests that CHD children have a significantly higher risk of ADHD when compared with those without CHD. Early identification and intervention of ADHD is important to reduce its symptoms and adverse effects; therefore, clinicians should increase screening for ADHD in children with CHD and intervene promptly to reduce its effects whenever possible.

show abstract

Section: Discussionmentioning

confidence: 99%

The risk of attention‐deficit hyperactivity disorder among children with congenital heart disease: A systematic review and meta‐analysis

Tang,

Ou,

Chen

et al. 2023

Child

View full text Add to dashboard Cite

show abstract

“…Children with cardiac conditions are reported to have increased behavioural concerns 13 . This could be related to hypoxia in the newborn period or minor brain injury in post‐operative CHD patients 14,15 . Of these behavioural issues, ADHD is a common condition which affects quality of life 2,16 …”

Section: Commentary and Critical Appraisalmentioning

confidence: 99%

“…13 This could be related to hypoxia in the newborn period or minor brain injury in post-operative CHD patients. 14,15 Of these behavioural issues, ADHD is a common condition which affects quality of life. 2,16 The first line medications used in the treatment of ADHD are stimulants.…”

Section: Commentary and Critical Appraisalmentioning

confidence: 99%

Safety of stimulant medications for attention deficit hyperactivity disorder in paediatric congenital heart disease

Chung

Hariharan

Varma

2023

J Paediatrics Child Health

View full text Add to dashboard Cite

Aim To review current literature regarding the safety of stimulant medications for treatment of attention deficit hyperactivity disorder in paediatric congenital heart disease (CHD) patients. Methods Embase, MEDLINE complete, CINAHL complete and Psychology and Behavioural Sciences Collection were searched for relevant articles from January 1980 to July 2022. Results One hundred and three articles were identified during the initial search after removal of duplicates. Thirty‐five articles were selected for review and 11 were included as relevant to the clinical question. Conclusions Stimulant medications are safe in patients with underlying CHD. In mild congenital cardiac conditions (ventricular septal defect, atrial septal defect and isolated semilunar valve disease), paediatricians can safely initiate stimulant therapy. With complex CHD cases, cardiology opinion is recommended prior to starting stimulants.

show abstract

“…Although environmental factors play a role in the disease, there is strong evidence that genetic factors also play a role in ASD [3]. Several studies in this area have been conducted to determine the effects of factors such as maternal obesity, neonatal icterus, gender, maternal age, complications, bleeding during pregnancy, congenital heart disease (CHD), low birth weight (less than 2500 grams), drug use during pregnancy, the presence the umbilical cord around the fetus's neck, preterm labor, intrauterine growth retardation (IUGR), no breastfeeding, and small for gestational age (SGA) [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

The Association between Threatened Abortion and the Risk of Autism Spectrum Disorders among Children: A Meta‐Analysis

Ahmadvand

Eghbalian

Nasrolahi

et al. 2023

BioMed Research International

View full text Add to dashboard Cite

Background. The current study is aimed at updating the observational studies on the relationship between threatened abortion and the risk of ASD. Methods. The search keywords were covered in three electronic databases PubMed, Web of Science, and Scopus up to April 2022. The modified Newcastle–Ottawa scale (NOS) was applied to detect the quality of epidemiological studies. We used the chi-square test and the I 2 statistic to show the heterogeneity among articles. I 2 more than 50% was considered high heterogeneity. Egger’s and Begg’s line regression tests were used for evaluating the publication bias. The random-effects model was applied for the analysis of the findings. The Stata 13.0 software package was applied for analysis and indicated p value less than 0.05 as a significant level. Results. The pooled analysis reported significant differences between threatened abortion and the risk of ASD in adjusted studies ( OR = 1.93 ; 95% CI: 1.12, 2.73; I 2 = 59.5.0 % ) and in crude studies ( OR = 2.17 ; 95% CI: 1.46, 2.88; I 2 = 39.5 % ). The evidence of publication bias was not found. Conclusions. The findings suggest that threatened abortion is a risk factor for ASD. As a result, screening tools to detect are necessary in mothers facing a threatened abortion.

show abstract

The association between congenital heart disease and the risk of Autism spectrum disorders or attention-deficit/hyperactivity disorder among children: a meta-analysis

Cited by 10 publications

References 27 publications

The risk of attention‐deficit hyperactivity disorder among children with congenital heart disease: A systematic review and meta‐analysis

The risk of attention‐deficit hyperactivity disorder among children with congenital heart disease: A systematic review and meta‐analysis

Safety of stimulant medications for attention deficit hyperactivity disorder in paediatric congenital heart disease

The Association between Threatened Abortion and the Risk of Autism Spectrum Disorders among Children: A Meta‐Analysis

Contact Info

Product

Resources

About