Psychosocial Factors and Survival of Young Women With Breast Cancer: A Population-Based Prospective Cohort Study

Abstract

Purpose Most women with early-stage breast cancer believe that psychosocial factors are an important influence over whether their cancer will recur. Studies of the issue have produced conflicting results. Patients and Methods A population-based sample of 708 Australian women diagnosed before age 60 years with nonmetastatic breast cancer was observed for a median of 8.2 years. Depression and anxiety, coping style, and social support were assessed at a median of 11 months after diagnosis. Hazard ratios for distant disease-free survival (DDFS) and overall survival (OS) associated with psychosocial factors were estimated separately using Cox proportional hazards survival models, with and without adjustment for known prognostic factors. Results Distant recurrence occurred in 209 (33%) of 638 assessable patients, and 170 (24%) of 708 patients died during the follow-up period. There were no statistically significant associations between any of the measured psychosocial factors and DDFS or OS from the adjusted analyses. From unadjusted analyses, associations between greater anxious preoccupation and poorer DDFS and OS were observed (P = .02). These associations were no longer evident after adjustment for established prognostic factors; greater anxious preoccupation was associated with younger age at diagnosis (P = .03), higher tumor grade (P = .02), and greater number of involved axillary nodes (P = .008). Conclusion The findings do not support the measured psychosocial factors being an important influence on breast cancer outcomes. Interventions for adverse psychosocial factors are warranted to improve quality of life but should not be expected to improve survival.

Symptom Experience and Quality of Life in Breast Cancer Survivors

“…이 시기 동안 유방암 환자가 경험하 는 신체적, 정서적 증상 고통이 심할수록 일상생활의 복귀와 적 응이 어려워지기 때문에 치료가 종료된 후 유방암 환자가 경험 하는 증상에 대한 관리와 중재의 중요성을 강조하고 있다 (Janz et al, 2007;Paskett et al, 2008). (Lu et al, 2009;Phillips et al, 2008;Thompson, 2007). 더욱이 최근 국외 에서는 유방암 생존자의 건강문제와 적응에 대한 관심이 높아 지면서 암 생존자에 대한 연구들이 꾸준히 실시되는 것에 반해 (Alfano & Rowland, 2006;Janz et al, 2007) (Table 4).…”

“…이는 유방암 생존자로서 살아가야 하는 기간이 증가함을 의미하므로 치료종료 후 유방암 생존자의 삶의 질은 중요한 건강문제 중 하 나이다 (Mrozek & Shapiro, 2005;Phillips et al, 2008).…”

Sintomas depressivos no câncer de mama: Inventário de Depressão de Beck - Short Form

“…Alguns autores observaram que a depressão foi preditor para aumento da mortalidade 17,18 . Porém, segundo outros autores, estresse psicossocial não influencia na evolução da doença nem no aumento da mortalidade 19 .…”

Descrição Do Apoio Social Ofertado Às Mulheres Em Tratamento Do Câncer De Mama: Importância Para O Prognóstico

“…Alguns autores observaram que a depressão influencia no aumento da mortalidade (GOODWIN, 2004). Porém, outros afirmam que estresses psicossociais não alteram o curso natural da doença nem da mortalidade (PHILLIPS, 2008).…”