Psychosocial factors and venous thromboembolism: a long‐term follow‐up study of Swedish men

Rosengren, Annika; Fredén, M.; Hansson, Per‐Olof; Wilhelmsen, Lars; Wedel, Hans; Eriksson, Henry

doi:10.1111/j.1538-7836.2007.02857.x

Cited by 150 publications

(172 citation statements)

References 30 publications

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“…Another study by Rosengren et al [20]it showed that SES variables such as persistent stress and low occupational class were independently related to future PE, while no such significant relationship could be demonstrated between DVT and SES [20]. It is also important to note that this study [20], which to the best of our knowledge is the only that has evaluated possible associations of this kind, was performed in male subjects only.…”

Section: Introductionmentioning

confidence: 77%

“…It is therefore of great interest to know whether variables reflecting the SES of an individual are related to the risk for VTE in the same way as has been shown for different manifestations of arterial vascular disease [4][5][6][11][12], In 1981, a study by Samkoff et al demonstrated an increased rate of PE in subjects with less than 8 years of education compared to in subjects with longer education [19]. Another study by Rosengren et al [20]it showed that SES variables such as persistent stress and low occupational class were independently related to future PE, while no such significant relationship could be demonstrated between DVT and SES [20]. It is also important to note that this study [20], which to the best of our knowledge is the only that has evaluated possible associations of this kind, was performed in male subjects only.…”

Section: Introductionmentioning

confidence: 99%

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Socioeconomic factors and concomitant diseases are related to the risk for venous thromboembolism during long time follow-up

Isma

Merlo

Ohlsson

et al. 2012

J Thromb Thrombolysis

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Link to publication Citation for published version (APA): Isma, N., Merlo, J., Ohlsson, H., Svensson, P., Lindblad, B., & Gottsäter, A. (2013). Socioeconomic factors and concomitant diseases are related to the risk for venous thromboembolism during long time follow-up. Journal of Thrombosis and Thrombolysis, 36(1), 58-64. DOI: 10.1007/s11239-012-0858-8 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal The association between socioeconomic data and concomitant diseases at the baseline investigation 1990 and incidence of VTE during follow-up was examined by Cox proportional hazard modelsResults: During the 13 years prospective follow-up, 10212 women and 7922 men were diagnosed with VTE. In both genders, age above 40 years at baseline, low income, single status, and a lower level of education were associated with an increased risk of VTE.However, both men and women born outside of Sweden have a lower risk for VTE during follow-up,however. Conclusion:Age above 40 years, low income, single marital status, and lower level of education were independently related to an increased risk of VTE diagnosis during 13 years of prospective follow-up.

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Section: Introductionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Socioeconomic factors and concomitant diseases are related to the risk for venous thromboembolism during long time follow-up

Isma

Merlo

Ohlsson

et al. 2012

J Thromb Thrombolysis

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“…Women with trauma exposure who did not report PTSD symptoms also exhibited increased risk of VTE incidence compared to women with no trauma exposure, although the magnitude of elevated risk was not as substantial as for women with high PTSD symptom levels. Initial research has linked psychosocial factors, including chronic stress36 and depression,9, 10 to VTE risk. Our study further underscores the role that psychosocial variables may play in contributing to the development of VTE, and suggests that the experience of extremely stressful, traumatic events and related posttraumatic stress reactions may have even more widespread cardiotoxic effects than has previously been considered.…”

Section: Discussionmentioning

confidence: 99%

Associations of Trauma Exposure and Posttraumatic Stress Symptoms With Venous Thromboembolism Over 22 Years in Women

Sumner

Kubzansky

Kabrhel

et al. 2016

JAHA

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BackgroundTrauma exposure and posttraumatic stress disorder (PTSD) have been linked to myocardial infarction and stroke in women, with biological and behavioral mechanisms implicated in underlying risk. The third most common cardiovascular illness, venous thromboembolism (VTE), is a specific health risk for women. Given previous associations with other cardiovascular diseases, we hypothesized that high levels of trauma and PTSD symptoms would be associated with higher risk of incident VTE in younger and middle‐aged women.Methods and ResultsWe used proportional hazards models to estimate hazard ratios (HRs) and 95% CIs for new‐onset VTE (960 events) over 22 years in 49 296 women in the Nurses’ Health Study II. Compared to no trauma exposure, both trauma exposure and PTSD symptoms were significantly associated with increased risk of developing VTE, adjusting for demographics, family history, and childhood adiposity. Women with the most PTSD symptoms exhibited the greatest risk elevation: trauma/6 to 7 symptoms: HR=2.42 (95% CI, 1.83–3.20); trauma/4 to 5 symptoms: HR=2.00 (95% CI, 1.55–2.59); trauma/1 to 3 symptoms: HR=1.44 (95% CI, 1.12–1.84); trauma/no symptoms: HR=1.72 (95% CI, 1.43–2.08). Results were similar, although attenuated, when adjusting for VTE‐relevant medications, medical conditions, and health behaviors.ConclusionsWomen with the highest PTSD symptom levels had nearly a 2‐fold increased risk of VTE compared to women without trauma exposure in fully adjusted models. Trauma exposure alone was also associated with elevated VTE risk. Trauma and PTSD symptoms may be associated with a hypercoagulable state. Treatment providers should be aware that women with trauma exposure and PTSD symptoms may be vulnerable to VTE.

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“…However, the overall diagnostic validity of the Swedish Inpatient Register is close to 90% [30]. Moreover, the diagnosis of VTE in the Swedish Inpatient Register has been validated and found to be correct in 95% of VTE diagnoses [46]. In addition, in 91% of cases, VTE is diagnosed by an objective method [46].…”

Section: Familial History and Unusual Forms Of Vtementioning

confidence: 99%

Familial risks of unusual forms of venous thrombosis: a nationwide epidemiological study in Sweden

Zöller

Sundquist

et al. 2010

Journal of Internal Medicine

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Zöller B, Li X, Sundquist J, Sundquist K. (Center for Primary Health Care Research, Lund University, Malmö, Sweden; Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, USA). Familial risks of unusual forms of venous thrombosis: a nationwide epidemiological study in Sweden. J Intern Med 2011; 270: 158–165. Abstract. Objective. This is the first nationwide study to determine familial risks of unusual forms of venous thrombosis amongst offspring of affected parents and amongst siblings. Design and settings. The Swedish Multigeneration Register of 0‐ to 75‐year‐old subjects was linked to the Hospital Discharge Register for the period 1987–2007. Standardized incidence ratios (SIRs) were calculated for individuals whose relatives were hospitalized for venous thromboembolism (VTE), as determined by the International Classification of Diseases, compared to those whose relatives were not affected by VTE. Results. The total number of hospitalized patients with VTE was 45 362, of which 1824 (4.0%) were affected by a rare thrombotic condition. The familial SIRs in cases with a history of VTE in parents or siblings were significantly increased for migrating thrombophlebitis (1.81; 95% confidence interval (CI) 1.40–2.31), portal vein thrombosis (2.35; 95% CI 1.77–3.06), vena cava thrombosis (1.96; 95% CI 1.42–2.64) and cerebral venous thrombosis (1.74; 95% CI 1.30–2.28). Budd–Chiari syndrome (SIR, 0.92; 95% CI 0.24–2.38) and renal vein thrombosis (SIR, 1.72; 95% CI 0.62–3.77) were not significantly associated with parental or sibling history of VTE; however, these two conditions were very rare, and therefore, we cannot draw any definite conclusions from this finding. Conclusions. Family history is an important risk factor for most unusual forms of VTE. Moreover, even the paraneoplastic phenomenon, migrating thrombophlebitis (Trousseau’s syndrome), is associated with a family history of VTE. Thus, our data suggest that most rare forms of VTE have a familial background.

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Psychosocial factors and venous thromboembolism: a long‐term follow‐up study of Swedish men

Cited by 150 publications

References 30 publications

Socioeconomic factors and concomitant diseases are related to the risk for venous thromboembolism during long time follow-up

Socioeconomic factors and concomitant diseases are related to the risk for venous thromboembolism during long time follow-up

Associations of Trauma Exposure and Posttraumatic Stress Symptoms With Venous Thromboembolism Over 22 Years in Women

Familial risks of unusual forms of venous thrombosis: a nationwide epidemiological study in Sweden

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