“…Most patients were aware of the importance of psychological interventions for the DFU treatment -re ecting a belief in the mind-body connection -although some patients may feel reluctant to participate in psychological interventions due to prejudice or shame, or even because they feel emotionally overwhelmed by the emotional consequences of the disease. Therefore, the moment when the intervention is made available is extremely important [42] Caregivers also highlighted the role of psychological status for successful treatments, determination, positive thinking (T.G.1), and acceptance of the disease (T.G.2), highlighting caregivers' awareness of the importance of psychological intervention to help the patient accept the disease. [46] Patients, especially those from T.G.1, reported that DFU was a source of negative emotions and consequences, such as sadness, anger, revolt, and anguish, living with the fear of amputation and trauma, [8-9, 43] and dealing with the impossibility to work.…”