Psychosocial Issues in Pediatric Nonalcoholic Fatty Liver Disease

Karaivazoglou, Katerina; Καλογεροπούλου, Μαρία; Assimakopoulos, Stelios F.; Triantos, Christos

doi:10.1016/j.psym.2018.09.001

Cited by 15 publications

(12 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…83 In addition, youth-onset NAFLD has been associated with a variety of psychosocial issues as low self-esteem, psychological distress and poor quality of life. 84 Thus, it is not surprising that, aligning with the evidence outlined above, the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) suggests screening for comorbidities such as T2DM, hypertension and dyslipidemia in children with NAFLD, 85 and this list of comorbidities may increase in the future as more evidence is generated. However, despite these recommendations, only approximately half of paediatric gastroenterologists screen for those comorbidities.…”

Section: Comorb Id Itie S In Children With Nafldmentioning

confidence: 99%

“…Other comorbidities that NAFLD have been associated with include obstructive sleep apnoea (OSA), 80,81 lower whole bone mineral density 82 and polycystic ovary syndrome 83 . In addition, youth‐onset NAFLD has been associated with a variety of psychosocial issues as low self‐esteem, psychological distress and poor quality of life 84 . Thus, it is not surprising that, aligning with the evidence outlined above, the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) suggests screening for comorbidities such as T2DM, hypertension and dyslipidemia in children with NAFLD, 85 and this list of comorbidities may increase in the future as more evidence is generated.…”

Section: Comorbidities In Children With Nafldmentioning

confidence: 99%

See 1 more Smart Citation

Perspectives on youth‐onset nonalcoholic fatty liver disease

Castillo‐Leon

Cioffi

Vos

2020

Endocrino Diabet & Metabol

View full text Add to dashboard Cite

Nonalcoholic fatty liver disease (NAFLD) is becoming increasingly well-known for being the most common chronic liver disease in the world. While NAFLD has been documented across the full lifespan, from newborn to those advanced in age, the increase in children with NAFLD is of particular concern. Prior studies suggest that youth with NAFLD exhibit a more progressive form of the disease, including increased fibrosis, compared to adults with

show abstract

Section: Comorb Id Itie S In Children With Nafldmentioning

confidence: 99%

Section: Comorbidities In Children With Nafldmentioning

confidence: 99%

Perspectives on youth‐onset nonalcoholic fatty liver disease

Castillo‐Leon

Cioffi

Vos

2020

Endocrino Diabet & Metabol

View full text Add to dashboard Cite

show abstract

“…Treating children with OSA has been shown to improve NAFLD severity and optimisation of Vitamin D levels may minimise fibrosis [58,59]. Given the frequent association with psychological morbidity, the provision of psychological support as part of multi-disciplinary management may contribute to improved clinical outcomes [60].…”

Section: Management Of Co-morbidities and Risk Factorsmentioning

confidence: 99%

Non-alcoholic fatty liver disease and childhood obesity

Shaunak

Byrne

Davis³

et al. 2020

Arch Dis Child

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD) in children and adolescents has an estimated prevalence of 36.1% in the context of obesity. This figure is anticipated to increase in conjunction with the global obesity epidemic. Worryingly, NAFLD in childhood persisting into adulthood is likely to be harmful, contributing to significant hepatic and extrahepatic morbidities. Early disease detection is required, although the optimum timing, frequency and mode of screening remains undetermined. While the efficacy of several medications, antioxidants, fatty acid supplements and probiotics has been investigated in children, healthy eating and physical activity remain the only prevention and treatment strategies for paediatric NAFLD. This short review discusses the epidemiology, diagnosis, pathogenesis and management of NAFLD in childhood obesity.

show abstract

“…Children and adolescents with hepatic steatosis have reported diminished QoL, including increased anxiety, depression, and low self-esteem [69]. Furthermore, hepatic encephalopathy has been associated with impairment in daily functioning, learning ability, sleep disturbances, and an increased risk of falls warranting hospitalization [70].…”

Section: Qol Impactmentioning

confidence: 99%

Clinical manifestations and management of fatty acid oxidation disorders

Merritt

MacLeod

Jurecka

et al. 2020

Rev Endocr Metab Disord

View full text Add to dashboard Cite

Fatty acid oxidation disorders (FAOD) are a group of rare, autosomal recessive, metabolic disorders caused by variants of the genes for the enzymes and proteins involved in the transport and metabolism of fatty acids in the mitochondria. Those affected by FAOD are unable to convert fatty acids into tricarboxylic acid cycle intermediates such as acetyl-coenzyme A, resulting in decreased adenosine triphosphate and glucose for use as energy in a variety of high-energy–requiring organ systems. Signs and symptoms may manifest in infants but often also appear in adolescents or adults during times of increased metabolic demand, such as fasting, physiologic stress, and prolonged exercise. Patients with FAOD present with a highly heterogeneous clinical spectrum. The most common clinical presentations include hypoketotic hypoglycemia, liver dysfunction, cardiomyopathy, rhabdomyolysis, and skeletal myopathy, as well as peripheral neuropathy and retinopathy in some subtypes. Despite efforts to detect FAOD through newborn screening and manage patients early, symptom onset can be sudden and serious, even resulting in death. Therefore, it is critical to identify quickly and accurately the key signs and symptoms of patients with FAOD to manage metabolic decompensations and prevent serious comorbidities.

show abstract

Psychosocial Issues in Pediatric Nonalcoholic Fatty Liver Disease

Cited by 15 publications

References 39 publications

Perspectives on youth‐onset nonalcoholic fatty liver disease

Perspectives on youth‐onset nonalcoholic fatty liver disease

Non-alcoholic fatty liver disease and childhood obesity

Clinical manifestations and management of fatty acid oxidation disorders

Contact Info

Product

Resources

About