Psychosocial risk factors for depression during pregnancy

Bunevičius, Robertas; Kusminskas, Laima; Bunevičius, Adomas; Nadišauskienė, Rūta Jolanta; Jurėnienė, Kristina; Pop, Victor J.M.

doi:10.1080/00016340902846049

Cited by 145 publications

(141 citation statements)

References 27 publications

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“…We found no significant association between unplanned pregnancies and suicide ideation, as has been shown in other research in pregnancy in South Africa [8,9], however, rates of unplanned pregnancies were pervasive in this sample, and substantial qualitative data supports the notion that for suicidal women an unplanned pregnancy, together with either partner or family conflict over the unplanned nature of the pregnancy, was a significant psychosocial stressor which frequently triggered suicide ideation. Partner conflict and intimate partner violence are strongly associated with antenatal depression in this region [9,15] and with both antenatal depression and suicide ideation in other LMICs [6,7,27,32] .…”

Section: Correlates Of Suicide Ideationmentioning

confidence: 87%

Suicide ideation, depression and HIV among pregnant women in rural South Africa

Rochat¹,

Bland²,

Tomlinson³

et al. 2013

Health

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Background: Despite public perception to the contrary, pregnancy does not offer a protective effect for suicide ideation. In low and middle income countries (LMIC) multiple concurrent risk factors including unplanned pregnancies, testing for HIV, intimate partner violence and depression may increase suicide risk among pregnant women. We examine suicide ideation among women attending routine antenatal care in rural South Africa. Method: A consecutive series of 109 women in the second half of pregnancy were enrolled in a cross-sectional study at a large primary health care facility in a rural area of KwaZulu-Natal with high HIV prevalence. Using a mixed-methods approach, women were assessed using the

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Section: Correlates Of Suicide Ideationmentioning

confidence: 87%

Suicide ideation, depression and HIV among pregnant women in rural South Africa

Rochat¹,

Bland²,

Tomlinson³

et al. 2013

Health

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“…The occurrence of stressors during the lifespan has been described as an important risk factor for depressive disorders [51,52], including peripartum depressive episodes [53,54]. The CRHR1 polymorphisms seem to modulate the sensitivity to stress, probably through their role in the regulation of HPA axis function, increasing the risk of depression [29,55]; but, unfortunately, our data do not allow us to establish causal relationships.…”

Section: Implications Of Polymorphisms In the Crhr1 Gene On The Hypotmentioning

confidence: 58%

Implications of Polymorphisms in the CRHR1 Gene on the Hypothalamic-Pituitary-Adrenal Axis Functioning in Postpartum Depression

Rezende¹,

Figueiredo²,

Garcia-Leal³

et al. 2018

Neuropsychiatry

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Objective:This study was aimed at assessing the association of the TAT haplotype of the corticotropinreleasing hormone receptor type 1 (CRHR1) with the function of the hypothalamic-pituitaryadrenal (HPA) axis in depressive and euthymic women in the remote postpartum period. Methods:The sample (mean age = 27.9 ± 5.3 years) consisted of 37 depressed postpartum women, of which 26 had one or two copies of the TAT haplotype (D-TAT ) and 20 without the TAT haplotype (E-TAT 0 ). Salivary cortisol samples were collected immediately upon awakening and 30 minutes, 3 hours and 12 hours later, approximately in the sixth month after delivery (mean = 169.6 ± 60.3 days). DNA for genotyping was extracted between 22 and 25 weeks of pregnancy. Results: D-TAT1/2 women presented lower cortisol awakening response (CAR) compared with E-TAT 1/2 and E-TAT 0 women. Independently of the diagnosis of depression, only women with at least one copy of the TAT haplotype presented a negative correlation between CAR and scores of perceived stress during pregnancy and depressive symptoms in the postpartum. Conclusion:The association between CRHR1 polymorphisms and postpartum depression may be mediated by variability in individual responses to stress as assessed through HPA axis responsiveness.

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“…previous depression, young maternal age, unplanned pregnancy and previous abuse), was also gathered. (21)(22)(23) Following clinical diagnosis, antidepressant medication was offered to participants, who were also counselled on its use. As some women had concerns regarding the fetal side effects of antidepressant therapy, only participants who gave consent were administered the medication.…”

Section: Methodsmentioning

confidence: 99%