Psychosocial stress alters ethanol's effect on open field behaviors

Blakley, Gregory G.; Pohorecky, Larissa A.

doi:10.1016/j.pbb.2006.04.005

Cited by 20 publications

(19 citation statements)

References 55 publications

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“…The lack of hierarchical or housing differences in locomotor activity at the diad test confirms previous reports (del Pozo et al 1978). Other investigators noted that Sdom rodents and rodents defeated in a resident-intruder test were either more (Blanchard et al 2001;Nikulina et al 2004) or less active than DOM rodents (Blakley and Pohorecky 2006;Meerlo et al 1996). These apparent inconsistencies may be attributed to experimental variables, such as handling and pre-test injection, which may have had significant biobehavioral consequences (Gariépy et al 2002;Hall et al 1997;Sciolino et al 2010).…”

Section: Discussionsupporting

confidence: 83%

“…For example, indices of a less emotional state or a greater "risk taking" trait predicted future social rank (Blakley and Pohorecky 2006;Blanchard et al 1998Blanchard et al , 2001Davis et al 2009). Furthermore, DOM rats tended to be stress hyper-responsive, while subordinate rats had an impaired, hyposensitive hypothalamo-pituitary-adrenal axis (Blanchard et al 1995;Pohorecky et al 2004a).…”

Section: Discussionmentioning

confidence: 99%

“…As a model of psychosocial stress, we employed a diad-housing variant of the triadhousing model developed in our laboratory. This model allows for the rapid development of a stable and robust social hierarchy among co-housed male rats (Blakley and Pohorecky 2006;Pohorecky et al 1999Pohorecky et al , 2004a. We evaluated AMP's behavioral effects on rats using the widely employed open field test.…”

Section: Introductionmentioning

confidence: 99%

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Differential sensitivity to amphetamine’s effect on open field behavior of psychosocially stressed male rats

Pohorecky¹,

Sweeny²,

Buckendahl³

2011

Psychopharmacology

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Differential sensitivity to amphetamine’s effect on open field behavior of psychosocially stressed male rats

Pohorecky¹,

Sweeny²,

Buckendahl³

2011

Psychopharmacology

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“…Research using this experimental approach has revealed that acute and chronic ethanol effects, as well as intake of ethanol, are affected by strength and type of various stress factors, including social stressors. [19–25]. In contrast, only a few studies have explicitly compared effects of ethanol in preweanling rats across different conditions of social isolation.…”

Section: Introductionmentioning

confidence: 99%

The role of social isolation in ethanol effects on the preweanling rat

Kozlov

Nizhnikov

Spear

2012

Behavioural Brain Research

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The present experiments investigated the effects of acute ethanol exposure on voluntary intake of 0.1% saccharin or water as well as behavioral and nociceptive reactivity in twelve–day-old (P12) rats exposed to differing levels of isolation. The effects of ethanol emerged only during short-term social isolation (STSI) with different patterns observed in males and females and in pups exposed to saccharin or water. The 0.5 g/kg ethanol dose selectively increased saccharin intake in females, decreased rearing activity in males and attenuated isolation-induced analgesia (IIA) in all water-exposed pups. Ingestion of saccharin decreased IIA, and the 0.5 g/kg ethanol dose further reduced IIA. The 1.0 g/kg ethanol dose, administered either intragastrically or intraparentionally, also decreased IIA in P12 females, but not in P9 pups. A significant correlation between voluntary saccharin intake and baseline nociceptive reactivity was revealed in saline injected animals, saccharin intake was inversely correlated with behavioral activation and latency of reaction to noxious heat after 0.5 g/kg ethanol in females. The 0.5 g/kg ethanol dose did not affect plasma corticosterone (CORT) measured 5 hours after maternal separation or 20 minutes after ethanol injection. Female pups CORT level was inversely correlated with magnitude of IIA that accompanied the first episode of STSI (pretest isolation) 1.5–2 hours before CORT measurement. The present findings suggest that the anxiolytic properties of ethanol are responsible for enhancement of saccharin intake during STSI. Furthermore, differential reactivity of P12 males and females to STSI plays an important role in ethanol effects observed at this age.

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“…32 Thus, the quantity of movements becomes an indicator of exploratory behavior and indicates an improvement in the animal's tissue and functional repair process. 33 Although Blakley 34 cites that rats with greater stress and anxiety have less exploratory behavior, which can explain the decrease in the number of crossings and rearings in the third week, which was resumed in the fourth week.…”

Section: Discussionmentioning

confidence: 99%

Efeito da cinesioterapia na lesão isquêmica e reperfusão em ratos

et al. 2012

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ObjectiveTo investigate the effect of kinesiotherapy on the functionality of the pelvic limb of rats after ischemic and reperfusion injury.Methods10 rats were divided into two groups, GI (control) and GII (kinesiotherapy). All the animals underwent ischemia for a period of three hours, followed by tissue reperfusion. In Group GII, non-resistive systemic kinesiotherapy was performed (swimming) in three weekly sessions of 50 minutes, over a period of four weeks, while the GI animals remained at rest. Functional analysis of motor behavior was evaluated weekly. The animals were then sacrificed, and the soleus and gastrocnemius muscles and the sciatic nerve removed for histopathological analysis.ResultsThere was a significant recovery of motor behavior with kinesiotherapeutic treatment during the four weeks of treatment. However, the histological examination of the tissues showed no morphological changes of cell injury and repair.ConclusionIt was not possible to affirm that the exercise was effective in cell repair, because neither of the groups (control and experimental) showed any histological difference. On the other hand, systemic kinesiotherapy showed a beneficial effect on functional rehabilitation after ischemia and reperfusion. Level of evidence III, Case-Control Study.

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Psychosocial stress alters ethanol's effect on open field behaviors

Cited by 20 publications

References 55 publications

Differential sensitivity to amphetamine’s effect on open field behavior of psychosocially stressed male rats

Differential sensitivity to amphetamine’s effect on open field behavior of psychosocially stressed male rats

The role of social isolation in ethanol effects on the preweanling rat

Efeito da cinesioterapia na lesão isquêmica e reperfusão em ratos

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