Psychosocial Stress Increases Salivary Alpha-Amylase Activity Independently from Plasma Noradrenaline Levels

Petrakova, Liubov; Doering, Bettina K.; Vits, Sabine; Engler, Harald; Rief, Winfried; Schedlowski, Manfred; Grigoleit, Jan-Sebastian

doi:10.1371/journal.pone.0134561

Cited by 83 publications

(67 citation statements)

References 17 publications

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“…Psychobiologists have documented rapid elevations in sAA following a wide array of acute cognitive, physical, emotional and psychosocial challenges in laboratory contexts (Doane and Van Lenten, ; Nater and Rohleder, ; Nater et al, ; Petrakova et al, ; Schumacher et al, ; Strahler et al, ). Other researchers have evaluated sAA responses to chronic stress or to shifting socioecological contexts in everyday life (Adam et al, ; Lynn et al, ; O'Donnell et al, ; Schumacher et al, ; Thoma et al, ; Vigil et al, ; Wolf et al, ).…”

Section: Salivary Autonomic Biomarker: α‐Amylasementioning

confidence: 99%

Beyond catecholamines: Measuring autonomic responses to psychosocial context

DeCaro

2015

American J Hum Biol

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Despite longstanding interest among human biologists in autonomic responses to socioecological context or culture change, the adoption of autonomic measures has been limited by methodological challenges. Catecholamine secretion is the most direct measure, but not all study designs are amenable to urinary sampling, and blood pressure lacks specificity to the parasympathetic or sympathetic division of the autonomic nervous system. This article reviews three alternative approaches for measuring autonomic responses: salivary α-amylase as a nonspecific autonomic marker, respiratory sinus arrhythmia as a specific parasympathetic marker, and the pre-ejection period as a specific sympathetic marker. Study design considerations are discussed in detail, including ambulatory sampling protocols that permit the evaluation of autonomic responses to everyday life. Researchers interested in how culture and social experience "get under the skin," as well as those concerned with the evolution of social engagement, can benefit from these well-validated biomarkers that are nevertheless relatively novel in human biology. Am. J. Hum. Biol. 28:309-317, 2016. © 2015 Wiley Periodicals, Inc.

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Section: Salivary Autonomic Biomarker: α‐Amylasementioning

confidence: 99%

Beyond catecholamines: Measuring autonomic responses to psychosocial context

DeCaro

2015

American J Hum Biol

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“…Salivary alpha-amylase (sAA) is considered a noninvasive biomarker for sympathetic nervous system (SNS) activity [6] and it increases with psychological and physical stress in people [6,7]. In humans, the evaluation of sAA activity and concentration is used as an alternative to measuring serum catecholamine concentration [6,8], which is more expensive and difficult to measure. Measurement of sAA activity and concentration has been described in horses using immunofluorometric and spectrophotometric assays [4].…”

Section: Introductionmentioning

confidence: 99%

Salivary alpha‐amylase activity and concentration in horses with acute abdominal disease: Association with outcome

Contreras-Aguilar¹,

Martı́nez-Subiela²,

Cerón³

et al. 2019

Equine Veterinary Journal

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Summary Background Salivary biomarkers could be useful to objectively evaluate critical illness and prognosis for survival in horses with acute abdominal disease. Objectives To compare salivary alpha‐amylase (sAA) activity and concentration in healthy horses and horses with acute abdominal disease, and evaluate the association between sAA activity and concentration with disease severity and outcome. Study design A prospective cohort. Methods sAA activity, measured using a colorimetric commercial kit, and concentration, measured using a Time‐resolved immunofluorometric assay, in 25 healthy horses and in 33 horses with acute abdominal disease was compared using an ANOVA. Associations between survival to discharge and sAA activity and concentration and other clinical parameters were examined using univariable logistic regression and Spearman correlation. Results sAA activity and concentration were different between healthy (median = 4.3 [2.6–11.2] IU/L and 58.4 [53.4–80.6] ng/mL, respectively) and diseased (median = 29.8 [14.2–168.9] IU/L and 388.3 [189.1–675.8] ng/mL, respectively) (P<0.001). The sAA activity was higher in non‐survivors (median = 479.0 [78.7–2064.0] IU/L, n = 8) compared to survivors (median = 19.3 [12.1–103.7] IU/L, n = 25, P<0.001) and sAA activity and concentration correlated (P<0.001) moderately with HR (r = 0.66 and r = 0.61, respectively). sAA activity correlated weakly with salivary cortisol (r = 0.45, P<0.001) and systemic inflammatory response syndrome score (r = 0.43, P<0.05), while activity and concentration correlated (P<0.001) moderately with plasma lactate concentration (r = 0.57 and r = 0.60, respectively). The sAA activity was significantly (P = 0.01) associated with increased risk of nonsurvival. Main limitations Pain scores were not recorded. The sample population was small. Conclusions The sAA activity, but not concentration, shows potential as a biomarker of prognosis for survival in horses with acute abdominal disease. The summary is available in Spanish – see Supporting Information

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“…4 Alpha-amylase is an enzyme that has been shown to be a marker of sympathetic nervous system activity as levels increase in humans in response to stressors. 5 Inducing psychosocial stress in early 2nd and 3rd trimester pregnant women resulted in attenuation of alpha-amylase in the stress response compared to nonpregnant women and prolonged cortisol recovery in early 2nd trimester pregnant women compared to early 3rd trimester pregnant and non-pregnant women. 6 Many risk factors for PPD have been identified, including poor marital and social support, life stressors, low self-esteem, pessimism about pregnancy, and antenatal depression and anxiety.…”

Section: Introductionmentioning

confidence: 99%

Salivary cortisol during memory encoding in pregnancy predicts postpartum depressive symptoms: a longitudinal study

Williams

Frey

2017

Trends Psychiatry Psychother.

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Trends in Psychiatry and Psychotherapy Brief Communication ResumoIntrodução: A depressão pós-parto é um transtorno prevalente que afeta negativamente a qualidade de vida da mãe e da criança. Neste estudo longitudinal, nós investigamos se a memória emocional, o cortisol salivar (salivary cortisol, sCORT) ou alfa-amilase durante a gravidez predizem sintomas depressivos no período pós-parto. Métodos: Um total de 44 mulheres grávidas [14 eutímicas com diagnóstico de transtorno depressivo maior (TDM) e 30 voluntárias sadias] entre 19 e 37 anos de idade (idade média = 29.5±4.1 anos) foram avaliadas longitudinalmente no 2º trimestre da gravidez (12-22 semanas de gestação) e na 14-17ª semana pós-parto. Sintomas depressivos foram avaliados com a Escala de Depressão Pós-Natal de Edimburgo (Edinburgh Postnatal Depression Scale, EPDS). Resultados: Quarenta e uma mulheres completaram o seguimento (7% de perda). sCORT coletado imediatamente antes de um teste de aquisição memória durante a gravidez foi preditor dos escores da escala EPDS no período pós-parto (b=-0.78, t -2.14 , p=0.04). Memória emocional positiva (p=0.27) ou negativa (p=0.85) não foram preditores dos escores da escala EPDS no período pós-parto. Conclusão: Os resultados deste estudo indicam que altos níveis de sCORT durante um teste de aquisição de memória no 2º trimestre da gravidez foram associados com baixos escores na escala EPDS no período pós-parto. Uma vez que o eixo hipotálamo-hipófise-adrenal (HHA) tenha sido envolvido na neurobiologia do TDM, o papel do eixo HHA na depressão perinatal merece mais atenção. Descritores: Gravidez, depressão pós-parto, transtorno depressivo maior, cortisol salivar, memória emocional. AbstractIntroduction: Postpartum depression (PPD) is a common disorder that substantially decreases quality of life for both mother and child. In this longitudinal study, we investigated whether emotional memory, salivary cortisol (sCORT) or alphaamylase during pregnancy predict postpartum depressive symptoms. Methods: Forty-four pregnant women (14 euthymic women with a diagnosis of major depressive disorder [MDD] and 30 healthy women) between the ages of 19 and 37 years (mean age = 29.5±4.1 years) were longitudinally assessed in the 2nd trimester of pregnancy (12-22 weeks of gestational age) and again at 14-17 weeks postpartum. Depressive symptoms were assessed using the Edinburgh Postnatal Depression Scale (EPDS). Results: Follow-ups were completed for 41 women (7% attrition). Postpartum EPDS scores were predicted by sCORT collected immediately after an incidental encoding memory task during pregnancy (b=-0.78, t -2.14 , p=0.04). Postpartum EPDS scores were not predicted by positive (p=0.27) or negative (p=0.85) emotional memory. Conclusions:The results of this study indicate that higher levels of sCORT during a memory encoding task in the 2nd trimester of pregnancy are associated with lower postpartum EPDS scores. While the hypothalamus-pituitary-adrenal (HPA) axis has long been associated with the neurobiology of MDD, the role of the HPA...

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Psychosocial Stress Increases Salivary Alpha-Amylase Activity Independently from Plasma Noradrenaline Levels

Cited by 83 publications

References 17 publications

Beyond catecholamines: Measuring autonomic responses to psychosocial context

Beyond catecholamines: Measuring autonomic responses to psychosocial context

Salivary alpha‐amylase activity and concentration in horses with acute abdominal disease: Association with outcome

Salivary cortisol during memory encoding in pregnancy predicts postpartum depressive symptoms: a longitudinal study

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