Purpose: The purpose of this study was to investigate the relationship among COVID-19 obsession, occupational stress, resilience, and psychological well-being in general hospital nurses following the COVID-19 pandemic. Methods: The study analyzed the analysis of 143 structured questionnaires received from general hospital nurses in D city. Data were collected from August 22 to August 26, 2022. The SPSS/WIN 26.0 program was used for data analysis, which included the t-test, one-way ANOVA, the Scheffé test, Pearson’s correlation coefficient, and hierarchical regression analysis. Results: The following factors were found to affect the psychosocial well-being of nurses in general hospitals after the COVID-19 pandemic: resilience(β=-.56, <i>p</i><.001), occupational stress(β=20, <i>p</i>=.008), and COVID-19 obsession(β=.14, <i>p</i>=.048). These factors explained 43% of variance in psychosocial well-being, and the model fit was also significant(F=26.43, <i>p</i><.001). Conclusion: The results, obtained from a survey after the COVID-19 pandemic, suggest that it is necessary to develop and apply programs for the psychosocial well-being of nurses in general hospitals.