Psychotic symptoms in first‐episode and drug naïve patients with major depressive disorder: Prevalence and related clinical factors

Shen, Yanmei; Wei, Ying; Yang, Xuna; Zhang, Guangya; Du, Xiangdong; Jia, Qi; Lee, Seonjoo; Ma, Yuejiao; Lang, Xiaoe; Luo, Xuerong; Zhang, Xiang Yang

doi:10.1002/da.23026

Cited by 31 publications

(17 citation statements)

References 46 publications

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“…This study found that 31.5% of treatment-naïve adolescents and young adults with first depressive episodes had SA, which was higher than one previous study about the first-episode and drug naïve patients with MDD with a prevalence of 19.9% (42). Several possible reasons may contribute to this discrepancy.…”

Section: Discussioncontrasting

confidence: 71%

The Association Between Suicide Attempts, Anxiety, and Childhood Maltreatment Among Adolescents and Young Adults With First Depressive Episodes

Chen

Cao

et al. 2021

Front. Psychiatry

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Objective: Adolescents and young adults are susceptible to high-risk behaviors such as self-harm and suicide. However, the impact of childhood maltreatment on suicide attempts in adolescents and young adults with first episode of depression remains unclear. This study examined the association between suicide attempts and childhood maltreatment among adolescents and young adults with first depressive episodes.Methods: A total of 181 adolescents and young adults with first depressive episodes were included. The Child Trauma Questionnaire (CTQ), Beck Anxiety Inventory (BAI), and Patient Health Questionnaire-2 (PHQ-2) were used to assess childhood maltreatment and the severity of anxiety and depressive symptoms, respectively. The suicide item in the MINI-International Neuropsychiatric Interview (M.I.N.I.) 5.0 was used to assess the suicide attempts. Logistic regression analyses were used to explore the associated factors of suicide attempts.Results: The prevalence of SA in the total sample was 31.5% (95% CI = 24.9–38.1%). Multivariate logistic regression analyses revealed that the diagnosis of bipolar disorder (OR = 2.18, 95% CI = 1.07–4.40), smoking (OR = 2.64, 95% CI = 1.10–6.37), anxiety symptoms (OR = 1.05, 95% CI = 1.02–1.08), and childhood maltreatment (OR = 1.04, 95% CI = 1.01–1.07) were potential associated factors of SA. In addition, anxiety symptoms had a mediating effect on the relationship between childhood maltreatment and SA.Conclusion: Adolescents and young adults with first depressive episodes and having experiences of childhood maltreatment are at a high risk of suicide. The severity of anxiety symptoms may mediate the relation between childhood maltreatment and suicide attempts in this group of patients.

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Section: Discussioncontrasting

confidence: 71%

The Association Between Suicide Attempts, Anxiety, and Childhood Maltreatment Among Adolescents and Young Adults With First Depressive Episodes

Chen

Cao

et al. 2021

Front. Psychiatry

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“…Further, Cheng et al (34) found that FC between the lateral orbitofrontal cortex and the PC is increased in patients with depression and associated with depressive symptoms, such as inferiority, despair, and lack of self-worth. Moreover, Shen et al (35) showed that the cerebellar Crus2 region is associated with late-onset depression and early-onset depression in adulthood. The lower long-FCD values of the Cingulum and Cerebelum may therefore indicate abnormal activity in these brain regions and it can be associated with DON patients' pain and depression reaction (Table 5).…”

Section: Discussionmentioning

confidence: 99%

Regional brain changes in patients with diabetic optic neuropathy: a resting-state functional magnetic resonance imaging study

Chen

Cai

Liang

et al. 2021

Quant Imaging Med Surg

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Background: To evaluate functional connection density (FCD) in patients with diabetic optic neuropathy (DON) using the resting functional connectivity (FC) method, and to determine the abnormal areas of brain activity.Methods: Patients with DON (n=22; 10 male, 12 female) and healthy controls (HCs; n=22; 10 male, 12 female) were included in the study. The basic characteristics of the groups were matched. Functional magnetic resonance imaging (fMRI) was conducted with participants at rest, and long-and short-range FCD (long FCD and IFCD, respectively) were measured. Receiver operating characteristic (ROC) curve analysis was also conducted to determine whether DON and HC participants could be distinguished using fMRI indicators.Results: Compared with HCs, the long FCD values of the left lingual gyrus, right lingual gyrus, right fusiform gyrus, and medial and lateral cingulate gyri were decreased in patients with DON. Further, the IFCD values of the left superior temporal gyrus, left inferior temporal gyrus, right inferior temporal gyrus, left cerebellar area 8, and right cerebellar Crus2 area were higher in patients with DON than in the HCs.Conclusions: DON is associated with abnormal spontaneous brain activity. Our findings contribute to elucidating the mechanisms underlying the neuropathology of DON, and provide direction for further clinical research.

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“…We used the 24-item Hamilton Rating Scale for Depression (HAMD) (Williams, 1988) and the 14-item Hamilton Rating Scale for Anxiety (HAMA) (Thompson, 2015) to assess the severity of depression and anxiety symptoms. Notably, we used the Chinese versions of the HAMD and HAMA, which have been documented to show great reliability and validity (Zheng et al, 1988) and have been widely applied in the Chinese population (Guo et al, 2015; Lai et al, 2021; Shen et al, 2020; Tong et al, 2021).…”

Section: Methodsmentioning

confidence: 99%

Brain function mediates the association between low vitamin D and neurocognitive status in female patients with major depressive disorder

Zhao

Zhu

et al. 2022

Psychol. Med.

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Background Vitamin D is engaged in various neural processes, with low vitamin D linked to depression and cognitive dysfunction. There are gender differences in depression and vitamin D level. However, the relationship between depression, gender, vitamin D, cognition, and brain function has yet to be determined. Methods One hundred and twenty-two patients with major depressive disorder (MDD) and 119 healthy controls underwent resting-state functional MRI and fractional amplitude of low-frequency fluctuations (fALFF) was calculated to assess brain function. Serum concentration of vitamin D (SCVD) and cognition (i.e. prospective memory and sustained attention) were also measured. Results We found a significant group-by-gender interaction effect on SCVD whereby MDD patients showed a reduction in SCVD relative to controls in females but not males. Concurrently, there was a female-specific association of SCVD with cognition and MDD-related fALFF alterations in widespread brain regions. Remarkably, MDD- and SCVD-related fALFF changes mediated the relation between SCVD and cognition in females. Conclusion Apart from providing insights into the neural mechanisms by which low vitamin D contributes to cognitive impairment in MDD in a gender-dependent manner, these findings might have clinical implications for assignment of female patients with MDD and cognitive dysfunction to adjuvant vitamin D supplementation therapy, which may ultimately advance a precision approach to personalized antidepressant choice.

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Psychotic symptoms in first‐episode and drug naïve patients with major depressive disorder: Prevalence and related clinical factors

Cited by 31 publications

References 46 publications

The Association Between Suicide Attempts, Anxiety, and Childhood Maltreatment Among Adolescents and Young Adults With First Depressive Episodes

The Association Between Suicide Attempts, Anxiety, and Childhood Maltreatment Among Adolescents and Young Adults With First Depressive Episodes

Regional brain changes in patients with diabetic optic neuropathy: a resting-state functional magnetic resonance imaging study

Brain function mediates the association between low vitamin D and neurocognitive status in female patients with major depressive disorder

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