Psychotropic Drugs Levels in Seminal Fluid: A New Therapeutic Drug Monitoring Analysis?

Mazzilli, Rossella; Curto, Martina; Bernardini, Donatella De; Olana, Soraya; Capi, Matilde; Salerno, Gerardo; Cipolla, Fabiola; Zamponi, Virginia; Santi, Daniele; Mazzilli, Fernando; Simmaco, Maurizio; Lionetto, Luana

doi:10.3389/fendo.2021.620936

Cited by 10 publications

(6 citation statements)

References 22 publications

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“…TG is the core of lipoprotein and serves as an energy source for most tissues. Previous studies have shown that some kinds of fatty acids are potential biomarkers of semen quality [ 12 ]. Diacylglycerol (DG, DAG) is formed through the hydrolysis of TG.…”

Section: Discussionmentioning

confidence: 99%

Seminal plasma metabolomics and lipidomics profiling to identify signatures of pituitary stalk interruption syndrome

Guo

Wang

et al. 2022

Orphanet J Rare Dis

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Background Pituitary stalk interruption syndrome (PSIS) is a rare disease caused by congenital pituitary anatomical defects. The underlying mechanisms remain unclear, and the diagnosis is difficult. Here, integrated metabolomics and lipidomics profiling were conducted to study the pathogenesis of PSIS. Methods Twenty-one patients with PSIS (BD group) and twenty-three healthy controls (HC group) were enrolled. Basal information and seminal plasma samples were collected. Untargeted metabolomics and lipidomics analyses were performed using ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS). Results The metabolomics and lipidomics profiles of patients with PSIS changed. The prolactin signaling pathway and biosynthesis of amino acids were the main differentially modified metabolic pathways. The main differentially modified metabolites were triacylglycerols (TGs), phosphatidylethanolamine (PE), sphingomyelin (SM), ceramide (Cer) and phosphatidylcholines (PCs). Pregnenolones and L-saccharopine could achieve a diagnosis of PSIS. Conclusions Pregnenolones and L-saccharopine are potential biomarkers for a PSIS diagnosis.

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Section: Discussionmentioning

confidence: 99%

Seminal plasma metabolomics and lipidomics profiling to identify signatures of pituitary stalk interruption syndrome

Guo

Wang

et al. 2022

Orphanet J Rare Dis

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“…In addition, several studies have shown that the intake of psychotropic drugs can determine alteration of semen quality, mainly a significant impairment of progressive motility and sperm morphology [ 9 ]. Finally, androgens, anti-androgens, and opioids have also been linked with male infertility [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

The effects of non-andrological medications on erectile dysfunction: a large single-center retrospective study

Mazzilli

Zamponi

Mangini

et al. 2023

J Endocrinol Invest

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Purpose To evaluate the association among andrological diseases at the first outpatient visit and the medications taken by patients for other comorbidities, as well as the differential impact between specific medication and relative comorbidities. Methods This is a single-center retrospective study based on subjects who referred to the Andrology Unit with a well-defined andrological diagnosis. Results A total of 3752 subjects were studied (mean age ± DS 46.2 ± 16.5 years). A total of 19 categories of andrological diseases and 110 type of medications for other comorbidities were identified. ED was the most frequent andrological pathology at the first andrological examination (28.7%), followed by infertility (12.4%). The couple of variables that were statistically significant in the univariate association analysis (p < 0.001) were: ED and (a) antihypertensives; (b) antihyperglycemics; (c) lipids-lowering; (d) psychotropics. The univariate and multivariate regression analyses confirmed the association. All the related comorbidities were also significantly associated with the univariate analysis, and all remained significantly associated with multivariate analysis. A multivariate analysis was also conducted to analyze the association between ED and the following pairs of variables “DM-antihyperglycemics”, “dyslipidemia-lipids-lowering”, and “hypertension-antihypertensives”. In all cases, the pathology, but not the specific treatment, was significantly associated with ED. Conclusion ED is significantly associated with antihypertensive, antihyperglycemic, lipid-lowering, psychotropic drugs’ intake. Anyway, ED appears to be more related to the diseases than to the specific therapies. The definitive cause/effect relationship should be established based on future prospective studies.

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“…Pharmacological treatments used by male partners of infertile couples could negatively influence seminal parameters, affecting the sperm number as well as the sperm motility [ 1 ]. Medications can affect the male reproductive system through central hormonal effects, sexual function, effects on sperm function or direct gonadotoxic effects [ 2 , 3 ]. It is well known that chemotherapeutic agents could have a direct gonadotoxic effect.…”

Section: Introductionmentioning

confidence: 99%

“…It is well known that chemotherapeutic agents could have a direct gonadotoxic effect. Moreover, we recently found sperm progressive motility to be significantly reduced in subjects treated with psychotropic drugs [ 3 ]. Other medications have been less investigated.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Non-Andrological Medications on Semen Characteristics, Oxidative Stress and Inflammatory Parameters

et al. 2023

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Background and Objectives: The aim of this study was to evaluate the impact of medications on oxidative stress, inflammatory biomarkers and semen characteristics in males with idiopathic infertility. Materials and Methods: In this observational case-control clinical study, 50 men with idiopathic infertility were enrolled, of whom 38 (the study group) were on pharmacological treatment and 12 made up the control group. The study group was clustered according to the medications (Group A: anti-hypertensive, n = 10; Group B: thyroxine, n = 6; Group C: non-steroidal anti-inflammatory drugs, n = 13; Group D: miscellaneous, n = 6; Group E: lipid-lowering drugs, n = 4). Semen analyses were performed according to WHO 2010 guidelines. Interleukins (IL)-10, IL-1 beta, IL-4, IL-6, Tumor Necrosis Factor- alpha (TNF-alpha) and IL-1 alpha were determined using a solid-phase sandwich immunoassay. The diacron reactive oxygen metabolites, d-ROMs test, was performed by means of a colorimetric determination of reactive oxygen metabolites and measured with a spectrophotometer. Beta-2-microglobulin and cystatin-C were measured with an immunoturbidimetric analyzer. Results: No differences between the study and control groups for age and macroscopic and microscopic semen characteristics were found, nor were any differences found after clustering according to the drug categories. IL-1 alpha and IL-10 were significantly lower in the study group compared with the control group; IL-10 was significantly lower in groups A, B, C and D compared with the control group. Furthermore, a direct correlation between IL-1 alpha, IL-10 and TNF-alpha and leukocytes was found. Conclusions: Despite the sample size limitations, the data suggest a correlation between drug use and activation of the inflammatory response. This could clarify the pathogenic mechanism of action for several pharmacological classes on male infertility.

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Psychotropic Drugs Levels in Seminal Fluid: A New Therapeutic Drug Monitoring Analysis?

Cited by 10 publications

References 22 publications

Seminal plasma metabolomics and lipidomics profiling to identify signatures of pituitary stalk interruption syndrome

Seminal plasma metabolomics and lipidomics profiling to identify signatures of pituitary stalk interruption syndrome

The effects of non-andrological medications on erectile dysfunction: a large single-center retrospective study

The Impact of Non-Andrological Medications on Semen Characteristics, Oxidative Stress and Inflammatory Parameters

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