Psyllium (Plantago Ovata Forsk) Husk Powder as a Natural Superdisintegrant for Orodispersible Formulations: A Study on Meloxicam Tablets

Drakšienė, Gailutė; Kopustinskienė, Dalia M.; Lažauskas, Robertas; Bernatonienė, Jurga

doi:10.3390/molecules24183255

Cited by 10 publications

(11 citation statements)

References 30 publications

(56 reference statements)

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“…Mucilage can be assist wound healing. Polysaccharides derived from P. ovata were found to be an excellent superdisintegrant and suspending agent for drug-delivery systems [138]. Plantago can be applied in different forms-seeds, husks (also known as isabgol) with the epidermidis (dried seed coat) removed, leaves, oil, or mucilage.…”

Section: Plantagomentioning

confidence: 99%

The Renaissance of Plant Mucilage in Health Promotion and Industrial Applications: A Review

et al. 2021

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Plant mucilage is a renewable and cost-effective source of plant-based compounds that are biologically active, biodegradable, biocompatible, nontoxic, and environmentally friendly. Until recently, plant mucilage has been of interest mostly for technological purposes. This review examined both its traditional uses and potential modern applications in a new generation of health-promoting foods, as well as in cosmetics and biomaterials. We explored the nutritional, phytochemical, and pharmacological richness of plant mucilage, with a particular focus on its biological activity. We also highlighted areas where more research is needed in order to understand the full commercial potential of plant mucilage.

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Section: Plantagomentioning

confidence: 99%

The Renaissance of Plant Mucilage in Health Promotion and Industrial Applications: A Review

et al. 2021

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“…The results of effective pore radius demonstrate the wicking capability as well as the disintegration potential of MCC-SiO 2 and CMC-SiO 2 conjugates over pure MCC and CMC. The results of micromeritic study indicates that amongst the three ratios of MCC-SiO 2 and CMC-SiO 2 conjugates, 1:5 was the most effective ratio followed by 1:2.5 and 1:1 [16].…”

Section: Pre-compression Evaluationmentioning

confidence: 95%

Development and Evaluation of MCC-SiO2/CMC-SiO2 Conjugates as Tablet Super-Disintegrants

et al. 2022

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In the present study, microcrystallinecellulose–colloidal silicon dioxide (MCC-SiO2) and carboxymethylcellulose–colloidal silicon dioxide (CMC-SiO2) conjugates have been investigated as superdisintegrants in fast dissolving tablets (FDTs). MCC-SiO2 and CMC-SiO2 conjugates were prepared and micromeritic studies, FTIR, SEM and XRD methods were utilized for characterizing the powdered conjugates. The conjugates were used for the preparation of domperidone FDTs by direct compression and thewetting time, water absorption ratio, disintegration time and in vitro drug release were evaluated. Effective pore radius of MCC-SiO2 and CMC-SiO2 conjugates for 1:1, 1:2.5 and 1:5 was found to be 13.35 ± 0.31 µm, 15.66 ± 0.17 µm and 18.38 ± 0.44 µm, and 16.81 ± 0.24 µm, 20.12 ± 0.39 µm and 26.37 ± 0.24 µm, respectively, compared to 12.21 ± 0.23 µm for MCC and 13.65 ± 0.21 µm for CMC. The results of effective pore radius indicate the wicking capability as well as the disintegration potential of MCC-SiO2 and CMC-SiO2 conjugates over pure MCC and CMC. The results of wetting time, water absorption ratio and disintegration time for MCC-SiO2 conjugates were found to be in the range of 19 ± 1.21 to 30 ± 1.33 s, 42 ± 0.28 to 49 ± 0.47% and 15 ± 2 to 40 ± 1 s, and for CMC-SiO2 conjugates were found to be in the range of 21 ± 1.13 to 40 ± 1.17 s, 42 ± 0.94 to 49 ± 0.57% and 12 ± 2 to 20 ± 3 s, respectively. Conjugation of MCC and CMC with SiO2 led to the formation of a complex with remarkable tablet superdisintegrant potential that could be used in preparing fast disintegrating tablets.

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“…At the end of 24 h, swelling degree measured in term of increased in volume. To determine the overall swelling features, the swelling index test method is used 14 .…”

Section: Synthesis and Optimization Of Modified K-carrageenan By Chemmentioning

confidence: 99%

Modification of natural hydrocolloid as disintegrant in aceclofenac tablet formulation

Gupta

Manigauha

2021

J. Drug Delivery Ther.

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The purpose of present exploration was to modify kappa (k)-Carrageenan, by crosslinking, and assessed it as a tablet disintegrant to strengthen the solubility of the drug (aceclofenac) in tablet formulation. Modified k-Carrageenan was synthesized by reacting it with epichlorhydrin at heterogenous conditions. The swelling action of the product was investigated in order to optimize reaction circumstances for chemical cross-linking. Best modified k-Carrageenan procured by optimizing the reaction conditions and it was characterized for swelling index, particle size distribution, solubility, viscosity, gel strength and Fourier transform infrared spectroscopy (FTIR). Influence of modified k-Carrageenan on dissolution profile of therapeutic was also investigated along with other evaluation parameters. Modified k-Carrageenan exhibiting significant swelling index which is comparable to that of superdisintegrants. On comparative investigation as a tablet disintegrant by preparing anhydrous dicalcium phosphate tablet, modified k-Carrageenan showed disintegration time less than 20 seconds. Dissolution of aceclofenac (Class II) tablet formulaion utilizing modified k-Carrageenan was comparable with commercially available superdisintegrants. Faster dissolution of the accommodated drug was achieved with modified k-Carrageenan which was comparable with dissolution of the tablet formulation containing other superdisintegrants. The competent concentration of k-Carrageenan was found to be 5-15% as tablet disintegrant. Modified k-Carrageenan might be encouraging tablet disintegrant in fast dissolving formulations and can be worn in direct compression method. Keywords: k-Carageenan. Epichlorhydrin. Aceclofenac. Crosslinking. Superdisintegrant

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Psyllium (Plantago Ovata Forsk) Husk Powder as a Natural Superdisintegrant for Orodispersible Formulations: A Study on Meloxicam Tablets

Cited by 10 publications

References 30 publications

The Renaissance of Plant Mucilage in Health Promotion and Industrial Applications: A Review

The Renaissance of Plant Mucilage in Health Promotion and Industrial Applications: A Review

Development and Evaluation of MCC-SiO2/CMC-SiO2 Conjugates as Tablet Super-Disintegrants

Modification of natural hydrocolloid as disintegrant in aceclofenac tablet formulation

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