Pt(II) and Ag(I) complexes with acesulfame: Crystal structure and a study of their antitumoral, antimicrobial and antiviral activities

Synthesis, structural and spectroscopic characterization of thallium(I) acesulfamate

“…Saccharinate shows an unprecedented coordination behavior as it acts as chelating ligand through its N and carbonyl atoms with the N atom interacting simultaneously with both metal centers and also the sulfonyl O-atoms are involved in bonding [23]. Interestingly, the two polymeric complexes, [Ag(acesulfamate)] n [14] and [Ag(saccharinate)] n [24], although not identical, show relatively similar structural arrangements.…”

“…The study of this ligand constituted, during many years, one of the main research activities of Gligor Jovanovski, which can be considered as a central figure in the development of this peculiar field of chemistry and coordination chemistry. Similar to saccharinate, the acesulfamate anion presents different potential coordination sites: the iminic nitrogen, the carbonylic oxygen and the two sulfonyl oxygen atoms, and it can act as a monodentate, bidentate or bridging ligand, in the same way as saccharinate [6], as demonstrated by a number of acesulfamato metal complexes reported during the last years [7][8][9][10][11][12][13][14].…”

Silver sulfadoxinate: Synthesis, structural and spectroscopic characterizations, and preliminary antibacterial assays in vitro

“…It was then demonstrated [6] that Fox's antibacterial agent was a silver complex with sulfonamide. Among the many sulfonamides, silver sulfadiazine (AgSFD) was the one that showed the highest activity against bacteria, and was soon introduced in the clinic for the treatment of burn infections and skin ulcers as a topical cream [2,[4][5][6][7][8]. The good performance of silver sulfadiazine is mainly attributed to the presence of slowly released Ag + ions [9][10][11], with no sulfadiazine molecules being ever found inside of the bacterial cells.…”

Chemical, spectroscopic characterization and antibacterial activities in vitro of a novel gold(I)–ibuprofen complex

“…More recently, new gold(I) and silver(I) complexes with the amino acid N-acetyl-L-cysteine, which show antibacterial activities in vitro against Gram-positive and Gram-negative bacteria, were synthesized in our laboratories [6,7]. Also, a silver(I) complex with acesulfame was evaluated and preliminary biological studies revealed its antimicrobial activity against Mycobacterium tuberculosis as well as against Gram-positive and Gram-negative bacteria [8].…”