Pt nanoparticle decorated carbon nanotubes nanocomposite based sensing platform for the monitoring of cell-secreted dopamine

Li, Jing; Huang, Xin; Shi, Weishan; Jiang, Mengyuan; Tian, Lei; Su, Mengjie; Wu, Jie; Liu, Quan; Yu, Chunmei; Gu, Hongchen

doi:10.1016/j.snb.2020.129311

Cited by 25 publications

(14 citation statements)

References 57 publications

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“…The main focus was to achieve low detection limits, due to the fact that concentration of DA is extremely low in patients with neurological diseases [ 39 ]. In this context, PC-12 cell lines play an important role in the detection of DA in vivo, with several optical [ 40 , 41 , 42 ], electrochemical biosensing systems, fixed potential amperometry [ 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ] and voltametric ones [ 52 , 53 , 54 ], and electrical devices [ 55 , 56 ] being investigated, with great potential for diagnostic purposes being demonstrated.…”

Section: Metal Ions and Small Molecules Detectionmentioning

confidence: 99%

“…Several electrochemical biosensors were reported for DA detection in PC-12 cells, most of them using fixed potential amperometry [ 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ] and voltammetry [ 52 , 53 , 54 ].…”

Section: Metal Ions and Small Molecules Detectionmentioning

confidence: 99%

“…A nitrogen-doped mesoporous carbon nanosheets-based biosensor operated at +0.25 V and showed high sensitivity and selectivity for DA sensing with a detection limit of 10 nM [ 44 ], with a similar detection limit value of 9 nM achieved by a paper-based electrochemical sensor [ 46 ] and a slightly lower value of 5 nM by the one based on graphene oxide and AuNP with EDTA immobilized-poly(1,5-diaminonaphthalne) [ 45 ]. The use of a nanocomposite comprising Pt nanoparticles (PtNPs) decorated multi-wall carbon nanotubes (MWCNTs), allowed the lowest detection limit among the amperometric biosensors, with a value of 2 nM [ 47 ]. The release of neurotransmitters from PC12 cells under stimulation was selectively monitored by amperometry at carbon fiber electrode in order to detect either solely dopamine or dopamine and FFN102 altogether.…”

Section: Metal Ions and Small Molecules Detectionmentioning

confidence: 99%

“…Almost all electrochemical biosensors were successfully applied for DA detection released from PC-12 cells under K + [ 44 , 45 , 47 , 50 , 51 , 53 ] or nicotine [ 52 ] stimulation. An important applicability was achieved by the amperometric biosensor in [ 47 ] which was able to evaluate the effects of antipsychotic drug (aripiprazole) on the dopamine release from cells treated with high K + and by the paper-based one in [ 46 ] which monitored the DA released from damaged PC12 cells induced by amyloid-beta peptide (Aβ 25–35 ) and cell intervene models protected by curcumin and marrow mesenchymal stem cells.…”

Section: Metal Ions and Small Molecules Detectionmentioning

confidence: 99%

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PC-12 Cell Line as a Neuronal Cell Model for Biosensing Applications

et al. 2022

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PC-12 cells have been widely used as a neuronal line study model in many biosensing devices, mainly due to the neurogenic characteristics acquired after differentiation, such as high level of secreted neurotransmitter, neuron morphology characterized by neurite outgrowth, and expression of ion and neurotransmitter receptors. For understanding the pathophysiology processes involved in brain disorders, PC-12 cell line is extensively assessed in neuroscience research, including studies on neurotoxicity, neuroprotection, or neurosecretion. Various analytical technologies have been developed to investigate physicochemical processes and the biosensors based on optical and electrochemical techniques, among others, have been at the forefront of this development. This article summarizes the application of different biosensors in PC-12 cell cultures and presents the modern approaches employed in neuronal networks biosensing.

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Section: Metal Ions and Small Molecules Detectionmentioning

confidence: 99%

Section: Metal Ions and Small Molecules Detectionmentioning

confidence: 99%

Section: Metal Ions and Small Molecules Detectionmentioning

confidence: 99%

Section: Metal Ions and Small Molecules Detectionmentioning

confidence: 99%

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PC-12 Cell Line as a Neuronal Cell Model for Biosensing Applications

et al. 2022

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“…At the same time, some studies have demonstrated that metal nanoparticles (such as gold, platinum and silver) can be adsorbed on the surface of MWCNTs, thus greatly improving the performance of the sensor [ 29 ]. Gu et al [ 30 ] decorated platinum nanoparticles on the surface of MWCNTs modified electrode, which greatly improved the conductivity of the electrode and the electron transfer rate, and constructed a sensor with better analytical performance.…”

Section: Cell-based Electrochemical Sensorsmentioning

confidence: 99%

Electrochemical Cell-Based Sensor for Detection of Food Hazards

et al. 2021

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People’s health has been threatened by several common food hazards. Thus, it is very important to establish rapid and accurate methods to detect food hazards. In recent years, biosensors have inspired developments because of their specificity and sensitivity, short reaction time, low cost, small size and easy operation. Owing to their high precision and non-destructive characteristics, cell-based electrochemical detection methods can reflect the damage of food hazards to organisms better. In this review, the characteristics of electrochemical cell-based biosensors and their applications in the detection of common hazards in food are reviewed. The strategies of cell immobilization and 3D culture on electrodes are discussed. The current limitations and further development prospects of cell-based electrochemical biosensors are also evaluated.

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