Pt/TiO2 brain biocompatible nanoparticles: GBM treatment using the C6 model in Wistar rats

López, T.; Recillas, Sonia; Guevara, Patricia; Sotelo, Julio; Álvarez, M. C. Díaz; Odriozola, J.A.

doi:10.1016/j.actbio.2008.05.027

Cited by 30 publications

(20 citation statements)

References 30 publications

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“…Recent studies have shown that nanoparticles of inorganic polymers such as SiO 2 and TiO 2 used as catalytic supports of platinum complexes can interact with cancer cells (López et al 2008(López et al , 2010Trewyn et al 2008;Liu et al 2010;Chen et al 2007;Zhu et al 2010). In the present work we obtained NPt nanoparticles, using a chelate agent as solvent, these nanoparticles were characterized by physicochemical techniques and tested for in vitro activity against DNA.…”

Section: Introductionmentioning

confidence: 98%

Synthesis, characterization and in vitro cytotoxicity of Pt-TiO2 nanoparticles

et al. 2011

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The adverse toxicological profile of cisplatin (cisdichlorodiammineplatinum (II)), characterized by nephrotoxicity and neurotoxicity is the main factor that limit the clinical usefulness of this antineoplastic drug, specifically the possibility of applying it in effective high-dose regimens. In order to overcome these disadvantages, many efforts in the search for new drugs have been made. Due to this particularity, we obtained via sol-gel process Pt(acac) 2 -TiO 2 (NPt) nanostructured materials with antitumoral activity to be used as an alternative in the treatment of cancer tumors. The biocatalysts were prepared by the sol-gel route using the complex Pt(acac) 2 . Sol-gel parameters were controlled in order to obtain high platinum dispersion and particles in the nano-size range. TEM, FTIR, N 2 adsorption and XPS characterization studies of the samples were carried out. In order to investigate interactions between the biocatalyst and DNA, agarose gel electrophoresis was performed, and we observed the formation of DNA adducts. 45 minutes after contact, NPt completely degraded the DNA (cisplatin 120 minutes). These results demonstrate that using a metal supported and dispersed over an inorganic biocompatible oxide, can be effectively used in the treatment of localized tumors.

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Section: Introductionmentioning

confidence: 98%

Synthesis, characterization and in vitro cytotoxicity of Pt-TiO2 nanoparticles

et al. 2011

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“…[8][9][10] Drug carriers are made of polymer hydrogels [1][2][3][4][5]11,12 or of inorganic ceramic materials. [13][14][15][16][17][18][19][20][21][22][23] Drug delivery to the central nervous system has been a challenging area of research because of the restrictions imposed by the blood-brain barrier. This has led to different approaches to the transport of drugs to the brain, including microencapsulation with polymer hydrogels [1][2][3][4][5] and inorganic reservoirs that are placed in the brain.…”

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confidence: 99%

Cortisol controlled release by mesoporous silica

López

Ortiz

Alexander‐Katz

et al. 2009

Nanomedicine: Nanotechnology, Biology and Medicine

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“…Over the past decades, the TiO 2 derived nanosized materials have been widely investigated for vast applications, including gas sensors, photocatalysts, solar cells and biomedical applications [1][2][3][4][5]. More precisely, the TiO 2 based nanotubes (TNT) have been extensively studied since their peculiar properties, like high specific area, ionexchange ability and photocatalytic activity [6].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and application of layered titanates in the photocatalytic degradation of phenol

Ivanova

Penkova

Hidalgo

et al. 2015

Applied Catalysis B: Environmental

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This study proposes a direct synthetic route to single titanate sheets through the mild and versatile conditions of the "chimie douce". The stages of the production include the complexation of the titanium alkoxide precursor by benzoic acid, the formation of titanium oxo-clusters and their controlled transformation into single sheet titanates during the hydrolysis stage. The resulted material appears to be an excellent precursor for self -organized TiO 2 nanotubes formation which presents an excellent activity as photocatalyst in the photo-degradation of phenol.

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Pt/TiO2 brain biocompatible nanoparticles: GBM treatment using the C6 model in Wistar rats

Cited by 30 publications

References 30 publications

Synthesis, characterization and in vitro cytotoxicity of Pt-TiO2 nanoparticles

Synthesis, characterization and in vitro cytotoxicity of Pt-TiO2 nanoparticles

Cortisol controlled release by mesoporous silica

Synthesis and application of layered titanates in the photocatalytic degradation of phenol

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