Pterostilbene alleviates polymicrobial sepsis-induced liver injury: Possible role of SIRT1 signaling

Liu, Xiaojing; Yang, Xiaojiao; Han, Ling-Na; Ye, Feng; Liu, Min; Fan, Wanhu; Zhang, Kai; Kong, Ying; Zhang, Jian; Shi, Lei; Chen, Yunru; Zhang, Xi; Su, Lin

doi:10.1016/j.intimp.2017.05.022

Cited by 56 publications

(31 citation statements)

References 38 publications

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“…Moreover, these results were augmented by histological evidence showing distorted renal and hepatic architecture and increased tissue damage in CLP rats. Our findings are in accordance with several previous reports demonstrating liver and kidney dysfunction in septic rats [12,48,49]. On the other hand, the decreased serum hepatic and renal damage markers, which was substantiated with beneficial histological findings in the silymarin-treated animals highlight its hepatorenal protective effects.…”

Section: Discussionsupporting

confidence: 93%

Silymarin protects against sepsis-induced acute liver and kidney injury via anti-inflammatory and antioxidant mechanisms in the rat

Al-Kadi

Ahmed

El‐Tahawy

et al. 2020

Journal of advanced Biomedical and Pharmaceutical Sciences

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Sepsis is a leading cause of death among intensive care patients. During sepsis, exaggerated reaction to infection leads to massive production of reactive oxygen species and inflammatory mediators, which eventually leads to multiple organ damage. Silymarin is a well-known antioxidant and cytoprotective agent, which showed protective effects in different models of disease. Thus, we hypothesized that silymarin would be protective against sepsis-induced liver and kidney injury. Sepsis was induced in rats by the cecal ligation and puncture (CLP) method. Rats were divided into sham, CLP-non-treated and CLP treated with silymarin (100 mg/kg, i.p. 1 h following CLP). After 24 h, rats were euthanized for blood and tissue samples, which were used for assessment of MDA, NO, GSH, IL-6 and TNF-α levels and SOD activity, in addition to renal and hepatic function parameters. Survival study was conducted using another set of animals following the same previously mentioned procedure. Silymarin showed protective effects evidenced by enhanced overall survival following sepsis (80% in silymarin-treated vs. 20% in septic group), in addition to improvement of hepatic and renal function parameters and reduction of MDA, NO, IL-6 and TNF-α levels. Moreover, silymarin supported the endogenous antioxidant mechanisms via elevation of GSH levels and reinforcement of SOD activity. In conclusion, silymarin protects against sepsis-induced hepatic and renal injury, possibly via antioxidant and anti-inflammatory mechanisms.

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Section: Discussionsupporting

confidence: 93%

Silymarin protects against sepsis-induced acute liver and kidney injury via anti-inflammatory and antioxidant mechanisms in the rat

Al-Kadi

Ahmed

El‐Tahawy

et al. 2020

Journal of advanced Biomedical and Pharmaceutical Sciences

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“…Pterostilbene retard the skeletal muscle oxidative stress injury and mitochondrial dysfunction by activating (SIRT1)‐ forkhead box protein O1 (FOXO1)/p53 pathway in mouse with ischemia reperfusion (IR) injury . Pterostilbene reduces inflammatory response and inhibit hepatic apoptosis to alleviate sepsis‐induced liver injury; its potential mechanism is associated with Sirt1 activation . These studies demonstrate that petrostilbene act as a potent modulator of Sirt1.…”

Section: The Effect Of Resveratrol and Pterostilbene On Age‐related Mmentioning

confidence: 89%

“…In an osteoarthritis model, pterostilbene has protective effect on cartilage degeneration by modulating IL‐1β‐mediated inflammation via nuclear translocation of Nrf2 . Pterostilbene improves the survival rate and alleviate polymicrobial sepsis‐induced liver injury in mice is because of suppressed inflammatory response possibly associated with SIRT1 signaling activation . Pretreatment with pterostilbene lowered the expression of several proinflammatory cytokines, including TNFα, IL‐1β, IL‐6, and critical transcription factor p65 NF‐κB, through upregulating heme oxygenase‐1 (HO‐1) to prevent hypoxic‐ischemic brain injury in neonatal rats .…”

Section: The Effect Of Pterostilbene On Aging Biomarkersmentioning

confidence: 99%

Effect of resveratrol and pterostilbene on aging and longevity

2017

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Over the past years, several studies have found that foods rich in polyphenols protect against age-related disease, such as atherosclerosis, cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2 diabetes (T2D), hypertension and Alzheimer's disease. Resveratrol and pterostilbene, the polyphenol found in grape and blueberries, have beneficial effects as antiaging compounds through modulating the hallmarks of aging, including oxidative damage, inflammation, telomere attrition and cell senescence. In this review, we discuss the relationship between resveratrol and pterostilbene and possible aging biomarker, including oxidative stress, inflammation, and highcalorie diets. Moreover, we also discuss the positive effect of Abbreviations: ABTS, 2,2 0 -Azino-bis (3-ethylbenzothiazoline-6-sulfonic acid; Akt, v-akt murine thymoma viral oncogene; AMPK, AMP-activated kinase; ARE, antioxidant response element; C. elegans, Caenorhabditis elegans; cAMP, cyclic adenosine monophosphate; CCL3, C-C motif chemokine ligand 3; CNS, central nervous system; CREB, cAMP response element binding protein; CRP, c-reactive protein; DPPH, 2,2-diphenyl-1-picryl-hydrazyl; eNOS, endothelial nitric oxide synthase; ERK, extracellular-signal-regulated kinase; ER-a, estrogen receptor alpha; FOXO1, forkhead box protein O1; FOXO3, forkhead box O3A protein; GSH, glutathione; GSH-Px, glutathione peroxidase; GSK3b, glycogen synthase kinase 3 b; hTERT, human telomerase reverse transcriptase; HtrA2, HtrA serine peptidase 2; IDH2, dehydrogenase 2; IFN-c, interferon gamma; IL-18, interleukin-18; IL-1b, interleukin 1 b; IL-6, interleukin-6; LDL, low-density lipoprotein; LPS, lipopolysaccharides; MAPK, mitogen-activated protein kinase; MLC, myosin light chain; MMP-1, matrix metalloproteinase-1; MMP-2, matrix metalloproteinase-2; MMP-9, matrix metalloproteinase-9; MnSOD, manganese superoxide dismutase; mRNA, messenger RNA; mtROS, mitochondrial reactive oxygen species; NADPH, nicotinamide adenine dinucleotide phosphate; NALP-3, NACHT 5 LRR and PYD domainscontaining protein 3; NAMPT, nicotinamide phosphoribosyltransferase; NFAT, nuclear factor of activated T-cells; NF-rB, nuclear factor-jB; NO, nitric oxide; Nrf2, nuclear factor erythroid 2-related factor 2; NS, Nutritional Supplement; OA, osteoarthritis; oxoLDL, oxidized low-density lipoprotein; PARK7, Parkinson disease protein 7; PARKIN, parkinson juvenile disease protein; PGC-1a, peroxisome proliferator-activated receptor gamma coactivator 1-a; PINK1, PTEN-induced putative kinase 1; PKB, protein kinase B; RhoA, Ras homolog gene family 5 member A; ROCK2, Rho-associated 5 coiled-coil containing protein kinase 2; ROS, reactive oxygen species; SAMP8, senescence accelerated mouse-prone 8; SCID, severe combined immunodeficiency; SHR, spontaneously hypertensive rat; SIRT1, sirtuin 1; SIRT4, sirtuin 4; SOD, superoxide peroxidase; STZ, streptozotocin; T2D, type 2 diabetes; TIMP-1, TIMP metallopeptidase inhibitor 1; TLR5, toll-like receptor 5; TNF-a, tumor necrosis factor alpha; UVB, ultraviol...

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“…In the current study, our results suggest that Pte treatment dramatically decrease the levels of IL-1β and TNF-α, indicating the anti-infalmmatory effect of Pte in AKI induced by sepsis. It has been reported that Pte exerts protection against sepsis-induced liver injury (18). Liu et al (18) suggested that Pte decrease the infiltration of neutrophil into the liver.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that Pte exerts protection against sepsis-induced liver injury (18). Liu et al (18) suggested that Pte decrease the infiltration of neutrophil into the liver. So, neutrophil may be, at least, one of the target cells of Pte.…”

Section: Discussionmentioning

confidence: 99%

Pterostilbene attenuates acute kidney injury in septic mice

et al. 2018

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Abstract. Acute kidney injury (AKI) is a severe complication of sepsis with a high mortality and morbidity. Pterostilbene (Pte) has been suggested to confer anti-apoptotic and anti-inflammatory effects. In the current study, the effects of Pte on AKI were evaluated in septic mice. Cecal ligation and puncture surgery was performed to induce sepsis. The results suggested that Pte administration significantly decreased the levels of serum urea nitrogen and creatinine, and improved the survival rate of septic mice. Additionally, the renal injury induced by sepsis was attenuated by pterostilbene treatment. Notably, pterostilbene reduced Bcl-2-associated X protein expression, and levels of interleukin-1β and tumor necrosis factor-α, and upregulated B-cell lymphoma 2 expression. The results indicate that pterostilbene may serve as a potential therapeutic candidate for the treatment of AKI induced by sepsis.

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Pterostilbene alleviates polymicrobial sepsis-induced liver injury: Possible role of SIRT1 signaling

Cited by 56 publications

References 38 publications

Silymarin protects against sepsis-induced acute liver and kidney injury via anti-inflammatory and antioxidant mechanisms in the rat

Silymarin protects against sepsis-induced acute liver and kidney injury via anti-inflammatory and antioxidant mechanisms in the rat

Effect of resveratrol and pterostilbene on aging and longevity

Pterostilbene attenuates acute kidney injury in septic mice

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