Pterostilbene ameliorates type-2 diabetes mellitus – Induced depressive-like behavior by mitigating insulin resistance, inflammation and ameliorating HPA axis dysfunction in rat brain

Patil, Rashmi; Urmila, Aswar; Vyas, Nishant

doi:10.1016/j.brainres.2023.148494

Cited by 8 publications

(1 citation statement)

References 60 publications

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“…Basic research suggests that depression-like behavior caused by type 2 diabetes can be ameliorated by reducing insulin resistance, inflammation, and improving the HPA axis dysfunction [ 32 ]. To determine the causal relationship between insulin resistance and the risk of developing depression, in a Dutch cohort study that predicted the incidence of major depression using three measures of insulin resistance, the development of prediabetes between enrollment and the 2-year study visit was positively associated with the occurrence of major depression and positively predicted the occurrence of major depression over the 9-year follow-up period.…”

Section: Discussionmentioning

confidence: 99%

Association between dietary sugar intake and depression in US adults: a cross-sectional study using data from the National Health and Nutrition Examination Survey 2011–2018

Zhang,

Sun,

Liu

et al. 2024

BMC Psychiatry

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Background Studies examining whether diet sugar intake increases the risk of depression have produced inconsistent results. Therefore, we investigated this relationship, using the US’ National Health and Nutrition Examination Survey (NHANES) database. Methods This cross-sectional study included 18,439 adults (aged ≥ 20 years) from NHANES (2011–2018). Depressive symptoms were assessed using the nine-item version of the Patient Health Questionnaire (PHQ-9). Covariates, including age, sex, race/ethnicity, poverty-income ratio, education, marital status, hypertension, diabetes mellitus, cardiovascular disease, alcohol intake, smoking status, physical activity, and dietary energy intake, were adjusted in multivariate logistic regression models. Subgroup and threshold saturation effect analyses were performed. Results After adjusting for potential confounders, we found that a 100 g/day increase in dietary sugar intake correlated with a 28% higher prevalence of depression (odds ratio = 1.28, 95% confidence interval = 1.17–1.40, P < 0.001). Conclusion Dietary sugar intake is positively associated with depression in US adults.

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Section: Discussionmentioning

confidence: 99%

Association between dietary sugar intake and depression in US adults: a cross-sectional study using data from the National Health and Nutrition Examination Survey 2011–2018

Zhang,

Sun,

Liu

et al. 2024

BMC Psychiatry

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Design, Synthesis and Biological Activities Evaluation of Novel Pterostilbene‐urea Derivatives as Potential Anti‐ inflammatory Agents

Wang,

Huang,

Peng

et al. 2024

Chemistry & Biodiversity

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To remove the toxicity of 10‐Pterostilbene methylamine hydrochloride derivatives (PMDS ． HCl) and develop novel anti‐inflammatory agents, twenty‐five Pterostilbene‐urea derivatives (PUDs, Q1‐Q25) derived from PMDs were designed, synthesized, characterized by spectroscopic techniques and their anti‐inflammatory activity in vitro were evaluated. Results exhibited that compounds (Q1‐Q25) were low toxic or non‐toxic toward RAW264.7 and L02 cell lines at 20 μM/L. Eight bioactive agents (Q4‐Q10, Q20) displayed obvious inhibition ability against LPS‐induced NO release, with IC50(NO) values ranged from 9.96 to 33.89 μM/L. Meanwhile, they were potential COX‐2 inhibitors with IC50(COX‐2) values ranging from 39.42 to 179.84 nM/L. A roughly positive correlation were observed between the inhibitory abilities on LPS‐induced NO release and those on COX‐2. Q7 , Q10and Q20 manifested stronger COX‐2 inhibitory abilities than Celecoxib . The strongest anti‐inflammatory agent, Q20 (IC50 (NO) = 9.96 μM/L, IC50(COX‐2) = 39.42 nM/L) effectively inhibited the secretion of pro‐inflammatory factors such as IL‐1β (IC50 = 12.30 μM/L) and TNF‐α (IC50 = 9.07 μM/L) in a dose‐dependent manner. Western Blot analysis indicated that at low micromolar concentrations, Q20 obviously down‐regulated the expression of COX‐2, iNOS as well as TLR4 protein, and suppressed the activation of NLRP3 inflammasome and NF‐κB signal pathway.

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Comparative analyses of anti-inflammatory effects of Resveratrol, Pterostilbene and Curcumin: in-silico and in-vitro evidences

Patil,

Telang,

Aswar

et al. 2024

In Silico Pharmacol.

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Pterostilbene ameliorates type-2 diabetes mellitus – Induced depressive-like behavior by mitigating insulin resistance, inflammation and ameliorating HPA axis dysfunction in rat brain

Cited by 8 publications

References 60 publications

Association between dietary sugar intake and depression in US adults: a cross-sectional study using data from the National Health and Nutrition Examination Survey 2011–2018

Association between dietary sugar intake and depression in US adults: a cross-sectional study using data from the National Health and Nutrition Examination Survey 2011–2018

Design, Synthesis and Biological Activities Evaluation of Novel Pterostilbene‐urea Derivatives as Potential Anti‐ inflammatory Agents

Comparative analyses of anti-inflammatory effects of Resveratrol, Pterostilbene and Curcumin: in-silico and in-vitro evidences

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