2012
DOI: 10.1371/journal.pone.0044524
|View full text |Cite
|
Sign up to set email alerts
|

Pterostilbene-Induced Tumor Cytotoxicity: A Lysosomal Membrane Permeabilization-Dependent Mechanism

Abstract: The phenolic phytoalexin resveratrol is well known for its health-promoting and anticancer properties. Its potential benefits are, however, limited due to its low bioavailability. Pterostilbene, a natural dimethoxylated analog of resveratrol, presents higher anticancer activity than resveratrol. The mechanisms by which this polyphenol acts against cancer cells are, however, unclear. Here, we show that pterostilbene effectively inhibits cancer cell growth and stimulates apoptosis and autophagosome accumulation … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

6
80
1

Year Published

2013
2013
2018
2018

Publication Types

Select...
7
2

Relationship

0
9

Authors

Journals

citations
Cited by 86 publications
(88 citation statements)
references
References 51 publications
6
80
1
Order By: Relevance
“…However, Mena et al . recently demonstrated that caspase-independent apoptosis is also induced by pterostilbene, the mechanism of which involves lysosomal membrane permeabilization, and caspase 3 activity failed to increase after pterostilbene treatment in MCF-7 cells [15]. The caspase 3 expression was consistently shown in this tudy to be unchanged under pterostilbene treatment in MCF-7 cells with or without ER-α36 overexpression (Fig.…”
Section: Discussionsupporting
confidence: 62%
“…However, Mena et al . recently demonstrated that caspase-independent apoptosis is also induced by pterostilbene, the mechanism of which involves lysosomal membrane permeabilization, and caspase 3 activity failed to increase after pterostilbene treatment in MCF-7 cells [15]. The caspase 3 expression was consistently shown in this tudy to be unchanged under pterostilbene treatment in MCF-7 cells with or without ER-α36 overexpression (Fig.…”
Section: Discussionsupporting
confidence: 62%
“…Moreover, PTER has also been reported to induce LMP-mediated cell death which depends on HSP70 levels in several solid tumor cell lines. This report indicated that endogenous HSP70 levels were found to be higher in cells with lower PTER susceptibility (HT29 and MCF-7 cells) than cells with higher PTER susceptibility (A375 and A549 cells) and knockdown of HSP70 in HT29 or MCF-7 cells can increase the PTER-induced cell death [49]. However, in our preliminary study, the endogenous HSP70 levels did not correlate with their susceptibility for PTER-mediated cell death in AML cell lines (Figure S6 in File S1).…”
Section: Discussionmentioning
confidence: 86%
“…Recently, PTS has drawn more and more attention because of various health-promoting activities, such as antioxidant, anti-inflammatory, anti-diabetic, and prevention of age-related disease [8][9][10][11][12][13][14]. PTS possess anticancer properties against breast, colon, leukemia, liver, prostate, and lung cancers [15][16][17][18][19][20].…”
Section: Introductionmentioning
confidence: 99%