2015
DOI: 10.1016/j.jpba.2015.04.045
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UPLC–MS method for quantification of pterostilbene and its application to comparative study of bioavailability and tissue distribution in normal and Lewis lung carcinoma bearing mice

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Cited by 21 publications
(17 citation statements)
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“…Furthermore, pterostilbene decreased the expression of ERS-related proteins eIF2a, ICAM1, MMP9, and GRP78 under endoplasmic reticulum stress, which effectively reduced the inflammation of vascular endothelial cells [9]. Pterostilbene (IC 50 , 22.4 µmol/L) was more effective as an anti-inflammatory compound than resveratrol (IC 50 , 43.8 µmol/L) in inhibiting the occurrence of colon cancer in HT-29 human adenocarcinoma cell line [16].…”
Section: Anti-inflammation Activitymentioning
confidence: 98%
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“…Furthermore, pterostilbene decreased the expression of ERS-related proteins eIF2a, ICAM1, MMP9, and GRP78 under endoplasmic reticulum stress, which effectively reduced the inflammation of vascular endothelial cells [9]. Pterostilbene (IC 50 , 22.4 µmol/L) was more effective as an anti-inflammatory compound than resveratrol (IC 50 , 43.8 µmol/L) in inhibiting the occurrence of colon cancer in HT-29 human adenocarcinoma cell line [16].…”
Section: Anti-inflammation Activitymentioning
confidence: 98%
“…Pterostilbene had low molecular weight and good liposolubility, and its distribution volume (5.3 L/kg) was larger than that of whole body water (~0.7 L/kg). Li et al specifically revealed the tissue distribution of pterostilbene in C57 BL/6 mice [16]. The tissue concentrations at 20 min after oral administration of 28 mg/kg pterostilbene were in the following order: stomach > liver > testis > kidney > intestine > lung > brain > spleen > skeletal muscle > heart.…”
Section: Distributionmentioning
confidence: 99%
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“…However, different studies on stilbenes have shown that the second absorption peak of the native form occurs at different times depending on the molecule, the doses and the animal model used. This second absorption peak appeared around 60 min after oral administration of pterostilbene [63] and resveratrol [64,65] or more than 10 h for the trimer, α-viniferine [66], for example. Supplemental experiments such as bile analysis could confirm this hypothesis and determine in what form the molecule undergoes this enterohepatic circulation [67,68].…”
Section: Discussionmentioning
confidence: 99%
“…Pterostilbene is having low molecular weight, more lipophilic therefore it can be easily cross the blood-brain barrier, has greater bioavailability, and is more biologically active than resveratrol [35,36]. The brain is hugely susceptible to interruption of the blood supply without energy reserve.…”
Section: Discussionmentioning
confidence: 99%