Pterostilbene reduces oxidative stress, prevents hypertrophy and preserves systolic function of right ventricle in <i>cor pulmonale</i> model

Lacerda, Denise dos Santos; Türck, Patrick; Seolin, Bruna Gazzi de Lima; Colombo, Rafael; Ortiz, Vanessa Duarte; Bonetto, Jéssica Hellen Poletto; Carraro, Cristina Campos; Bianchi, S.; Belló‐Klein, Adriane; Bassani, Valquíria Linck

doi:10.1111/bph.13948

Cited by 39 publications

(31 citation statements)

References 68 publications

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“…Our finding that increased enzymatic antioxidant activity in MCT‐injected rats is not sufficient to prevent oxidative stress leading to lipid peroxidation (Figure , Table ) suggests an altered capacity of the nonenzymatic antioxidant system. Our data showing unchanged thiol‐based nonenzymatic antioxidants in hypertrophied RV is in agreement with similar studies . However, a decline in nonenzymatic antioxidants in the heart was reported in the MCT‐induced RV hypertrophy model .…”

Section: Discussionsupporting

confidence: 93%

“…Similar to other antioxidants B2BrBC and C66 treatment did not prevent RV hypertrophy (Table ) and this might be related to a weak effect of the applied dosages on pulmonary arterial function . Increased ROS are associated with proinﬂammatory and profibrotic events in the pressure‐overloaded myocardium and also induce antioxidant enzymes by direct activation of transcription factors .…”

Section: Discussionmentioning

confidence: 79%

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Antioxidant and anti‐inflammatory effects of the monocarbonyl curcumin analogs B2BRBC and C66 in monocrotaline‐induced right ventricular hypertrophy

Hadzi‐Petrushev

Angelovski

Rebok

et al. 2019

J Biochem & Molecular Tox

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For 22 days after monocrotaline injection two groups of rats received either of the monocarbonyl curcumin analogs (2E,6E)‐2,6‐bis(2‐bromobenzylidene)cycloxehanone (B2BrBC) and (2E,6E)‐2,6‐bis([2‐triﬂuoromethyl]benzylidene)cyclohexanone (C66), and their right ventricle parameters were compared to those from the control and the monocrotaline injected animals. B2BrBC and C66 treatments did not prevent the monocrotaline‐induced right ventricular hypertrophy but attenuated the changes in antioxidant enzyme activities and reduced inflammation. The level of thiol‐based nonenzymatic antioxidants did not change in the function of monocrotaline or curcumin analogs treatment. However, due to its stronger antioxidant properties, only B2BrBC treatment was effective in the reduction of monocrotaline‐associated lipid peroxidation. The obtained results suggest that increasing the levels of antioxidant enzymes may not be sufficient to reduce oxidative stress and chronic inflammation optimally and our current study supports the potential of compounds with more than one beneficial biological activity as a promising treatment against the progression of cardiac hypertrophy.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 79%

Antioxidant and anti‐inflammatory effects of the monocarbonyl curcumin analogs B2BRBC and C66 in monocrotaline‐induced right ventricular hypertrophy

Hadzi‐Petrushev

Angelovski

Rebok

et al. 2019

J Biochem & Molecular Tox

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“…Pterostilbene reduced malondialdehyde (MDA), 4‐hydroxynonenal (4‐HNE), aconitase‐2 and 8‐hydroxydeoxyguanosine (8‐OHdG) level; this suggests protective effects of pterostilbene on hyperosmolarity‐induced oxidative stress in human cornea epithelial cells . In vivo , Dos Santos Lacerda et al found that decrease in NADPH oxidase‐dependent superoxide anion production and oxidative stress may be the underlying mechanic of pterostilbene in cardioprotection, including maladaptative remodeling prevention and protection of systolic function in the right ventricle of rats with pulmonary hypertension . Pterostilbene also exerts protective activity on UVB‐induced skin damage and carcinogenesis by maintaining skin antioxidant defenses, including GSH levels, catalase, superoxide, and GSH peroxidase activities .…”

Section: The Effect Of Pterostilbene On Aging Biomarkersmentioning

confidence: 99%

Effect of resveratrol and pterostilbene on aging and longevity

2017

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Over the past years, several studies have found that foods rich in polyphenols protect against age-related disease, such as atherosclerosis, cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2 diabetes (T2D), hypertension and Alzheimer's disease. Resveratrol and pterostilbene, the polyphenol found in grape and blueberries, have beneficial effects as antiaging compounds through modulating the hallmarks of aging, including oxidative damage, inflammation, telomere attrition and cell senescence. In this review, we discuss the relationship between resveratrol and pterostilbene and possible aging biomarker, including oxidative stress, inflammation, and highcalorie diets. Moreover, we also discuss the positive effect of Abbreviations: ABTS, 2,2 0 -Azino-bis (3-ethylbenzothiazoline-6-sulfonic acid; Akt, v-akt murine thymoma viral oncogene; AMPK, AMP-activated kinase; ARE, antioxidant response element; C. elegans, Caenorhabditis elegans; cAMP, cyclic adenosine monophosphate; CCL3, C-C motif chemokine ligand 3; CNS, central nervous system; CREB, cAMP response element binding protein; CRP, c-reactive protein; DPPH, 2,2-diphenyl-1-picryl-hydrazyl; eNOS, endothelial nitric oxide synthase; ERK, extracellular-signal-regulated kinase; ER-a, estrogen receptor alpha; FOXO1, forkhead box protein O1; FOXO3, forkhead box O3A protein; GSH, glutathione; GSH-Px, glutathione peroxidase; GSK3b, glycogen synthase kinase 3 b; hTERT, human telomerase reverse transcriptase; HtrA2, HtrA serine peptidase 2; IDH2, dehydrogenase 2; IFN-c, interferon gamma; IL-18, interleukin-18; IL-1b, interleukin 1 b; IL-6, interleukin-6; LDL, low-density lipoprotein; LPS, lipopolysaccharides; MAPK, mitogen-activated protein kinase; MLC, myosin light chain; MMP-1, matrix metalloproteinase-1; MMP-2, matrix metalloproteinase-2; MMP-9, matrix metalloproteinase-9; MnSOD, manganese superoxide dismutase; mRNA, messenger RNA; mtROS, mitochondrial reactive oxygen species; NADPH, nicotinamide adenine dinucleotide phosphate; NALP-3, NACHT 5 LRR and PYD domainscontaining protein 3; NAMPT, nicotinamide phosphoribosyltransferase; NFAT, nuclear factor of activated T-cells; NF-rB, nuclear factor-jB; NO, nitric oxide; Nrf2, nuclear factor erythroid 2-related factor 2; NS, Nutritional Supplement; OA, osteoarthritis; oxoLDL, oxidized low-density lipoprotein; PARK7, Parkinson disease protein 7; PARKIN, parkinson juvenile disease protein; PGC-1a, peroxisome proliferator-activated receptor gamma coactivator 1-a; PINK1, PTEN-induced putative kinase 1; PKB, protein kinase B; RhoA, Ras homolog gene family 5 member A; ROCK2, Rho-associated 5 coiled-coil containing protein kinase 2; ROS, reactive oxygen species; SAMP8, senescence accelerated mouse-prone 8; SCID, severe combined immunodeficiency; SHR, spontaneously hypertensive rat; SIRT1, sirtuin 1; SIRT4, sirtuin 4; SOD, superoxide peroxidase; STZ, streptozotocin; T2D, type 2 diabetes; TIMP-1, TIMP metallopeptidase inhibitor 1; TLR5, toll-like receptor 5; TNF-a, tumor necrosis factor alpha; UVB, ultraviol...

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“…Moreover, previous results suggest that the PTS ? HPbCD complex is as effective as noncomplexed PTS in terms of its antioxidant activity, thus indicating that the combination with HPbCD does not change this property (Dos Santos Lacerda et al 2017). Therefore, the decision was made to explore the classical enzymatic antioxidant system in both in vitro protocols.…”

Section: Discussionmentioning

confidence: 99%

“…All reagents were of analytical or HPLC grade. The complex was prepared using 0.3 M HPbCD dissolved in water with an excess of PTS (Dos Santos Lacerda et al 2017;Yeo et al 2013). The complex was solubilised in Dulbecco's modified Eagle's medium (DMEM) and tested at concentrations of 50, 100 and 150 lM to establish the optimal concentration for the pretreatment of cardiac myoblasts (experiment I).…”

Section: Preparation Of Pts ? Hpbcdmentioning

confidence: 99%

Profile of pterostilbene-induced redox homeostasis modulation in cardiac myoblasts and heart tissue

et al. 2018

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This study was designed to investigate the effect of pterostilbene (PTS) on cardiac oxidative stress in vitro, as this is a simple and promising methodology to study cardiac disease. Cardiac myoblasts (H9c2 cells) and homogenised cardiac tissue were incubated with the PTS and cyclodextrin (PTS ? HPbCD) complex for 1 and 24 h, respectively, at concentrations of 50 lM for the cells and 25 and 50 lM for cardiac tissue. The PTS ? HPbCD complex was used to increase the solubility of PTS in water. After the pretreatment period, cardiomyoblasts were challenged with hydrogen peroxide (6.67 lM) for 10 min, while cardiac tissue was submitted to a hydroxyl radical generator system (30 min). Cellular viability, oxidative stress biomarkers (e.g. total reactive oxygen species (ROS), carbonyl assay and lipoperoxidation) and the antioxidant response (e.g. sulfhydryl and the antioxidant enzyme activities of superoxide dismutase, catalase and glutathione peroxidase) were evaluated. In cardiomyoblasts, the PTS ? HPbCD complex (50 lM) increased cellular viability. Moreover, the PTS ? HPbCD complex also significantly increased sulfhydryl levels in the cells submitted to an oxidative challenge. In cardiac tissue, lipid peroxidation, carbonyls and ROS levels were significantly increased in the groups submitted to oxidative damage, while the PTS ? HPbCD complex significantly reduced ROS levels in these groups. In addition, the PTS ? HPbCD complex also provoked increased catalase activity in both experimental protocols. These data suggest that the PTS ? HPbCD complex may play a cardioprotective role through a reduction of ROS levels associated with an improved antioxidant response.

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Pterostilbene reduces oxidative stress, prevents hypertrophy and preserves systolic function of right ventricle in cor pulmonale model

Cited by 39 publications

References 68 publications

Antioxidant and anti‐inflammatory effects of the monocarbonyl curcumin analogs B2BRBC and C66 in monocrotaline‐induced right ventricular hypertrophy

Antioxidant and anti‐inflammatory effects of the monocarbonyl curcumin analogs B2BRBC and C66 in monocrotaline‐induced right ventricular hypertrophy

Effect of resveratrol and pterostilbene on aging and longevity

Profile of pterostilbene-induced redox homeostasis modulation in cardiac myoblasts and heart tissue

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