Pterostilbene Supplementation Inhibits Early Inflammatory Response and Oxidative Stress in UVB-Induced BALB/C Mice

Abstract

Extended dermal exposure of ultraviolet B (UVB) can induce erythema, hyperpigmentation, epidermal hyperplasia and cancer. Natural active compound such as pterostilbene (PS) is a potential UV-protecting agent as it has broad biological activities. This study aimed to evaluate the photoprotective effect of pterostilbene on ultraviolet-B-induced BALB/c mice. Twenty-four female mice were randomised into four groups (n=6/group): vehicle control (VC); UVB irradiated only (UVB only); UVB irradiation treated with pterostilbene 10 mg/kg (PS10+UVB); (iv) UVB irradiation treated with pterostilbene 20 mg/kg (PS20+UVB). The PS treatments were given for 14 days, and UVB was given at dose 250 mJ/cm2 on days 9, 11, and 13 of the treatment periods. The results showed that PS lessened redness and scaling on the skin of UVB-irradiated mice. The skinfold thickness and epidermal thickness in the PS-treated group were significantly reduced (p<0.05) in comparison with those in the UVB only group. The PS10 and PS20 groups (5.927 ± 0.354 and 5.660 ± 0.765 nmol/g, respectively) demonstrated significantly decreased MDA levels (P<0.05) relative to the UVB only group (13.343 ± 1.350 nmol/g). The GSH level in both PS10 (0.555 ± 0.020 µmol/mg) and PS20 (0.568 ± 0.055 µmol/mg) groups increased significantly (p<0.05) compared with that in the UVB only group (0.376 ± 0.025 µmol/mg). SOD activity in the PS20 group (1.388 ± 0.172 U/min/mg) increased significantly (p<0.05) compared with that in the UVB only group (0.561 ± 0.034 U/min/mg). Histological observation showed that PS reduced leukocyte infiltration and epidermal hyperplasia. Hence, oral PS may exert a photoprotective effect by acting as an anti-inflammatory and antioxidant agent on UVB-irradiated mice skin.

Potential Chemopreventive Role of Pterostilbene in Its Modulation of the Apoptosis Pathway

“…Recently, pterostilbene has been studied extensively and has been proven to exhibit various pharmacological properties that make it a promising candidate to be developed as a chemopreventive agent, such as the properties of anti-inflammation, antioxidation, anti-proliferation, and detoxifying enzyme enhancement [108][109][110][111]. Numerous studies were carried out and revealed the potential of pterostilbene as an anti-cancer agent against the various types of cancer cell lines via in vitro and/or in vivo models.…”

Evaluation of Phytochemical Composition, Antioxidant and anti-Diabetic Activities of Mitragyna speciosa Methanolic Extract (MSME)

“…No. P1499, Sigma-Aldrich), a naturally occurring polyphenol with strong antioxidant properties, was used as a positive control (14).…”

Chemopreventive Effects of Oral Pterostilbene in Multistage Carcinogenesis of Skin Squamous Cell Carcinoma Mouse Model Induced by DMBA/TPA

“…According to numerous epidemiological and pre-clinical studies, consuming natural food such as vegetables, fruits, herbs, and spices has been linked to lowering the risk of developing cancer [ 9 , 10 ]. Stilbene-based natural compounds, such as resveratrol and pterostilbene, are widely studied polyphenols with numerous pharmacological properties, including anti-inflammatory, antioxidant, anti-cancer, anti-diabetic, and others [ 11 , 12 , 13 , 14 , 15 ]. However, pterostilbene possesses better pharmacokinetic properties compared to resveratrol, with a longer half-life in the body and greater bioavailability [ 16 , 17 ].…”