1996
DOI: 10.1002/jbmr.5650111004
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PTH-related protein is released into the mother's bloodstream during lactation: Evidence for beneficial effects on maternal calcium-phosphate metabolism

Abstract: Recent studies have indicated that parathyroid hormone-related protein (PTHrP) may have important actions in lactation, affecting the mammary gland, and also calcium metabolism in the newborn and the mother. However, there are as yet no longitudinal studies to support the notion of an endocrine role of this peptide during nursing. We studied a group of 12 nursing mothers, mean age 32 years, after they had been nursing for an average of 7 weeks (B) and also 4 months after stopping nursing (A). It was assumed th… Show more

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Cited by 81 publications
(34 citation statements)
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“…They observed the highest concentration of CTX in the first week of lactation in dairy cows. A significant increase in the concentration of PTHrP established in our study in early lactation is in agreement with the study conducted by Lippuner et al (1996) in humans, in which significantly higher PTHrP values were observed in the blood of lactating women than in that of nonlactating ones. The results of our study are probably connected with the role of PTHrP in the mammary gland during lactation, which is assumed to promote calcium transport in milk (Law et al, 1991;Barlet et al, 1992).…”
Section: Discussionsupporting
confidence: 93%
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“…They observed the highest concentration of CTX in the first week of lactation in dairy cows. A significant increase in the concentration of PTHrP established in our study in early lactation is in agreement with the study conducted by Lippuner et al (1996) in humans, in which significantly higher PTHrP values were observed in the blood of lactating women than in that of nonlactating ones. The results of our study are probably connected with the role of PTHrP in the mammary gland during lactation, which is assumed to promote calcium transport in milk (Law et al, 1991;Barlet et al, 1992).…”
Section: Discussionsupporting
confidence: 93%
“…In our study, the concentration of PTH slightly rose in lactation, but the differences were not significant, probably due to the high variability in PTH concentrations. The results of this study are at variance with the findings of a study conducted by Lippuner et al (1996) on humans. The latter authors observed decreased values of PTH in the blood of women in lactation.…”
Section: Discussioncontrasting
confidence: 87%
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“…PTHrP declines significantly during the post-weaning interval (558). Exactly when it disappears from the maternal circulation have not been established, but the variable response of hypoparathyroid women to weaning indicates that it may be gone by weaning or persist for up to many months (see sect.…”
Section: Pthrpmentioning
confidence: 99%
“…Large amounts of PTHrP are also secreted into breast milk [35], which contains 10 2 -10 5 the level of PTHrP in serum. When a large amount of PTHrP from the breast enters the bloodstream, it stimulates the movement of calcium from maternal bone into breast milk [36].…”
Section: Lactation-associated Hypercalcemiamentioning
confidence: 99%