2013
DOI: 10.1155/2013/476240
|View full text |Cite
|
Sign up to set email alerts
|

PTPIP51: A New Interaction Partner of the Insulin Receptor and PKA in Adipose Tissue

Abstract: Aims. Our previous experiments revealed an association of PTPIP51 (protein tyrosine phosphatase interacting protein 51) with the insulin signalling pathway through PTP1B and 14-3-3beta. We aimed to clarify the role of PTPIP51 in adipocyte metabolism. Methods. Four groups of ten C57Bl/6 mice each were used. Two groups were fed a standard diet; two groups were fed a high-fat diet. Two groups (one high-fat diet and one standard diet) were submitted to endurance training, while the remaining two groups served as u… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
4
0
1

Year Published

2014
2014
2024
2024

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 10 publications
(6 citation statements)
references
References 26 publications
1
4
0
1
Order By: Relevance
“…Regarding the photoreceptor inner segments, the co-localization of PTPIP51 with the ATP-synthase, a mitochondrial marker, suggests the association of PTPIP51 with this organelle, as previously described in other cell types (Lv et al, 2006;De Vos et al, 2012;Stoica et al, 2014). The variability of the subcellular localization in the rat retina is in agreement with previous studies, which reported different localization for PTPIP51 according to the cell type, but also resulting from the phosphorylation status of PTPIP51 and from the type of the interacting proteins involved (Stenzinger et al, 2009b;Brobeil et al, 2010Brobeil et al, , 2012Bobrich et al, 2013). Furthermore, different isoforms of variable molecular weight have been observed in many tissues, including mouse brain and retina (Stenzinger et al, 2005(Stenzinger et al, , 2009aMaerker et al, 2008;Koch et al, 2009;Brobeil et al, 2010).…”
Section: Discussionsupporting
confidence: 90%
“…Regarding the photoreceptor inner segments, the co-localization of PTPIP51 with the ATP-synthase, a mitochondrial marker, suggests the association of PTPIP51 with this organelle, as previously described in other cell types (Lv et al, 2006;De Vos et al, 2012;Stoica et al, 2014). The variability of the subcellular localization in the rat retina is in agreement with previous studies, which reported different localization for PTPIP51 according to the cell type, but also resulting from the phosphorylation status of PTPIP51 and from the type of the interacting proteins involved (Stenzinger et al, 2009b;Brobeil et al, 2010Brobeil et al, , 2012Bobrich et al, 2013). Furthermore, different isoforms of variable molecular weight have been observed in many tissues, including mouse brain and retina (Stenzinger et al, 2005(Stenzinger et al, , 2009aMaerker et al, 2008;Koch et al, 2009;Brobeil et al, 2010).…”
Section: Discussionsupporting
confidence: 90%
“…At least in part, PTP1B is suppressed by SirT1 to activate the IGFR . PTPIP51 (protein tyrosine phosphatase interacting protein 51) was shown to be connected to the insulin signaling pathway via PTP1B and 14–3–3beta in other studies . In a neuroblastoma cell line that resembles motor neurons, overexpression of PTPIP51 (OMM) and VAPB (ER) significantly increased the ER-mito contacts .…”
Section: Discussionmentioning
confidence: 95%
“…The expression of PTPIP51, which, in adipose tissue, acts as an effector in insulin signaling, has been correlated with insulin resistance [106]. Recent evidence has identified a role for this protein in adipocyte metabolism as a mediator between lipogenesis and lipolysis by switching between the lipogenic insulin pathway and the lipolytic PKA pathway via physical interaction with the insulin receptor and PKA [107]. VAPB-PTPIP51 tethers regulate autophagy by controlling Ca 2+ influx to mitochondria from the ER [40].…”
Section: Er-mitochondria Interfacementioning
confidence: 99%