PTPIP51 interaction with PTP1B and 14-3-3β in adipose tissue of insulin-resistant mice

Bobrich, Manuel; Brobeil, Alexander; Mooren, Frank C.; Krüger, Karsten; Steger, Klaus; Tag, Claudia; Wimmer, Monika

doi:10.1038/ijo.2010.283

Cited by 13 publications

(20 citation statements)

References 41 publications

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“…As PTPIP51 and PTP1B interact in neutrophil granulocytes of umbilical cord blood and peripheral venous blood, a signal transducing function of PTPIP51 can be assumed (Brobeil et al 2010). Moreover, Bobrich and coworkers have confirmed the interaction of PTPIP51 and PTP1B in mice adipose tissue (Bobrich et al 2011). Apart from this, the PTPIP51 protein, if overexpressed in HEK293T and in HeLa cells, is connected to the apoptotic machinery (Lv et al 2006). Hallmarks of apoptosis are divided into morphological and biochemical alterations.…”

Section: Present Experimental Data Concerning Ptpip51mentioning

confidence: 85%

“…Figure 6a, d, e illustrates the localization of the two conserved regions of the PTPIP51 protein. Two recent studies have added evidence that PTPIP51 is involved in the MAPK pathway (Bobrich et al 2011;M. Petri, P. Koch, A. Stenzinger, K. Kuchelmeister, U. Nestler, K. Steger, M. Viard, M. Wimmer, in preparation).…”

Section: Ptpip51 Protein: Isoforms Exhibit Functional Adapted Domainsmentioning

confidence: 96%

“…PTPIP51 expression is not correlated with the subtype of AML as classified by the However, the exact cellular function of PTPIP51 is still unknown. Recent studies on the impact of PTPIP51 on signalling pathways have identified PTPIP51 as being involved in the mitogen-activated protein kinase (MAPK) pathway (Yu et al 2008;Bobrich et al 2011). Yu and coworkers (2008) have shown that PTPIP51 is capable of increasing ERK activation by interacting with Raf-1 through 14-3-3 proteins.…”

Section: Present Experimental Data Concerning Ptpip51mentioning

confidence: 99%

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Protein tyrosine phosphatase interacting protein 51—a jack-of-all-trades protein

2011

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Protein tyrosine phosphatase interacting protein 51 (PTPIP51) interacts both in vitro and in vivo with PTP1B, a protein tyrosine phosphatase involved in cellular regulation. PTPIP51 is known to be expressed in many different types of tissues. It is involved in cellular processes such as proliferation, differentiation and apoptosis. Nevertheless, the exact cellular function of PTPIP51 is still unknown. The present review summarizes our current knowledge of the PTPIP51 gene and its mRNA and protein structure.

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Section: Present Experimental Data Concerning Ptpip51mentioning

confidence: 85%

Section: Ptpip51 Protein: Isoforms Exhibit Functional Adapted Domainsmentioning

confidence: 96%

Section: Present Experimental Data Concerning Ptpip51mentioning

confidence: 99%

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Protein tyrosine phosphatase interacting protein 51—a jack-of-all-trades protein

2011

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“…Mice in the training groups were trained in normoxia at 60% of their initial physical capacity (maximal running speed) 5 days/wk for 30 min each. One time per week, physical performance was reassessed as described above, to individually adapt the intensity of the exercise training for the following week (5). Sildenafil-treated mice and placebo-treated control mice that did not perform exercise were exposed daily to hypoxia for the same time period as exercising mice.…”

Section: Methodsmentioning

confidence: 99%

Structural and functional prevention of hypoxia-induced pulmonary hypertension by individualized exercise training in mice

Weißmann

Peters

Klöpping

et al. 2014

American Journal of Physiology-Lung Cellular and Molecular Phys

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Pulmonary hypertension (PH) is a disease with a poor prognosis characterized by a vascular remodeling process and an increase in pulmonary vascular resistance. While a variety of reports demonstrated that exercise training exerts beneficial effects on exercise performance and quality of life in PH patients, it is not known how physical exercise affects vascular remodeling processes occurring in hypoxia-induced PH. Therefore, we investigated the effect of individualized exercise training on the development of hypoxia-induced PH in mice. Training effects were compared with pharmacological treatment with the phosphodiesterase 5 inhibitor Sildenafil or a combination of training plus Sildenafil. Trained mice who received Sildenafil showed a significantly improved walking distance (from 88.9 ± 8.1 to 146.4 ± 13.1 m) and maximum oxygen consumption (from 93.3 ± 2.9 to 105.5 ± 2.2% in combination with Sildenafil, to 102.2 ± 3.0% with placebo) compared with sedentary controls. Right ventricular systolic pressure, measured by telemetry, was at the level of healthy normoxic animals, whereas right heart hypertrophy did not benefit from training. Most interestingly, the increase in small pulmonary vessel muscularization was prevented by training. Respective counterregulatory processes were detected for the nitric oxide-soluble guanylate cyclase-phosphodiesterase system. We conclude that individualized daily exercise can prevent vascular remodeling in hypoxia-induced PH.

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“…(Lv et al, 2006), proliferation or migration (Yu et al, 2008) and has also been linked with different pathological contexts such as acute myeloid leukemia (Brobeil et al, 2010) or insulin resistance . New partners of PTPIP51, such as the vesicle-associated membrane protein-associated protein B (De Vos et al, 2012;Stoica et al, 2014) and the 14-3-3 adaptorscaffold protein (Yu et al, 2008;Bobrich et al, 2011), have been described and their specific interaction with PTPIP51 could be involved in the regulation of calcium homeostatsis (De Vos et al, 2012), cell motility (Yu et al, 2008) and insulin resistance .…”

Section: Introductionmentioning

confidence: 99%

The protein tyrosine phosphatase interacting protein 51 (PTPIP51) is required for the differentiation of photoreceptors

et al. 2015

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Proliferation and differentiation of retinal progenitor cells (RPCs) are tightly controlled by extrinsic cues and distinct combinations of transcription factors leading to the generation of retinal cell type diversity. In this context, we investigated the role of the protein tyrosine phosphatase interacting protein 51 (PTPIP51) in the differentiation of RPCs. The expression pattern of PTPIP51 was analyzed by immunostaining during post-natal retinal development in the rat. Ex vivo electroporation has been used to silence or misexpress PTPIP51 in post-natal retinal explants, and the retinal phenotype was investigated after 3-7days in vitro (div). PTPIP51 expression in the retina started postnatally and was maintained throughout adulthood, especially in retinal ganglion cells and in the inner segment of photoreceptor cells. Silencing of Ptpip51 expression in postnatal retina failed to modify the commitment of late RPCs in the different lineages but severely impaired the final differentiation of photoreceptors, observed by a decrease in the fraction of Rhodopsin-positive cells after 7div. By contrast, misexpression of PTPIP51 in early or late RPCs failed to modify the differentiation of the RPCs. Our data demonstrate that PTPIP51 is implicated in the differentiation process of immature photoreceptors. Because PTPIP51 is specifically localized in the inner segment, PTPIP51 may contribute to the complex stage of maturation of the apical segment of these cells.

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PTPIP51 interaction with PTP1B and 14-3-3β in adipose tissue of insulin-resistant mice

Cited by 13 publications

References 41 publications

Protein tyrosine phosphatase interacting protein 51—a jack-of-all-trades protein

Protein tyrosine phosphatase interacting protein 51—a jack-of-all-trades protein

Structural and functional prevention of hypoxia-induced pulmonary hypertension by individualized exercise training in mice

The protein tyrosine phosphatase interacting protein 51 (PTPIP51) is required for the differentiation of photoreceptors

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