PTTG1-interacting protein (PTTG1IP/PBF) predicts breast cancer survival

Repo, Heli; Gurvits, Natalia; Löyttyniemi, Eliisa; Nykänen, Marjukka; Lintunen, Minnamaija; Karra, Henna; Kurki, Samu; Kuopio, Teijo; Talvinen, Kati; Söderström, Mirva; Kronqvist, Pauliina

doi:10.1186/s12885-017-3694-6

Cited by 26 publications

(21 citation statements)

References 22 publications

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“…The mean expression level of FOXM1 was previously reported to be the highest in the TNBC subtype, which was associated with poor prognosis and reduced survival time in patients with breast cancer (29,30). Notably, PTTG1 is an oncogene that is important for the progression of mitosis in the metaphase-anaphase transition (31,32). Additionally, PTTG1 overexpression is associated with malignancy, particularly thyroid, breast and colorectal carcinoma (32).…”

Section: Discussionmentioning

confidence: 99%

“…Notably, PTTG1 is an oncogene that is important for the progression of mitosis in the metaphase-anaphase transition (31,32). Additionally, PTTG1 overexpression is associated with malignancy, particularly thyroid, breast and colorectal carcinoma (32). A previous study indicated that PTTG1 is highly expressed in patients with breast cancer and that the expression levels were correlated with the degree of malignancy in breast cancer cell lines.…”

Section: Discussionmentioning

confidence: 99%

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High WDR34 mRNA expression as a potential prognostic biomarker in patients with breast cancer as determined by integrated bioinformatics analysis

Shi

et al. 2019

Oncol Lett

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The WD-repeat domain (WDR) family is distributed in the majority of eukaryotes and has several unique biological functions. It serves important roles in signal transduction, cytoskeleton assembly, protein transport, RNA processing, chromatin modification and transcription mechanisms. WD repeat domain 34 (WDR34) has been recently identified as a member of the WDR family. Overexpression of WDR34 was accompanied by the presence of multiple centrioles in the cell, suggesting that it was associated with tumor occurrence. However, its association with breast cancer was unclear. To the best of our knowledge, it has not yet been confirmed whether WDR34 gene expression is associated with breast cancer. Therefore, the current study attempted to clarify this by performing a comprehensive study using multiple datasets in the Oncomine, Breast Cancer Gene-Expression Miner and Kaplan-Meier Plotter databases. The analysis indicated that the mRNA expression levels of WDR34 were increased in breast cancer tissues compared with normal tissues. Consistent with this result, the Broad-Novartis Cancer Cell Line Encyclopedia revealed that WDR34 mRNA expression levels were upregulated in breast cancer cell lines compared with other cancer cells. It was noted that high WDR34 mRNA expression was associated with forkhead box M1 and PTTG1 regulator of sister chromatid separation, securing in co-expression analysis. Expression profile characteristics of WDR34 mRNA were identified in different molecular subtypes of breast cancer. Furthermore, survival analysis revealed that increased expression levels of WDR34 mRNA were associated with poor overall survival in patients with breast cancer, particularly in luminal B, lymph node status-positive and estrogen receptor (ER)-negative subgroups. Additionally, Kaplan-Meier curves revealed that high WDR34 mRNA expression was associated with shorter relapse-free survival in patients with breast cancer, particularly in ER-positive, human epidermal growth factor receptor 2-negative and progesterone receptor-positive subgroups. These results suggested that WDR34 may be used as a prognosis predictor in breast cancer and may provide a novel target for the diagnosis and treatment of breast cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

High WDR34 mRNA expression as a potential prognostic biomarker in patients with breast cancer as determined by integrated bioinformatics analysis

Shi

et al. 2019

Oncol Lett

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“…Pituitary tumor-transforming 3, pseudogene (PTTG3P), is a processed pseudogene that shows high homology to its family members, pituitary tumor-transforming 1 (PTTG1) and -2 (PTTG2) 8 . Numerous investigations have shown that PTTG1 and -2 serve as two key oncogenes in a variety of human cancers, including breast cancer,9, 10 lung cancer, 11 pituitary adenoma, 12 and esophageal squamous cell cancer 13 . However, there are only a few reports regarding the expression and roles of PTTG3P in cancer.…”

Section: Introductionmentioning

confidence: 99%

High Expression of Pseudogene PTTG3P Indicates a Poor Prognosis in Human Breast Cancer

Lou

Ding

Fan

2019

Molecular Therapy - Oncolytics

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Pseudogenes play pivotal roles in tumorigenesis. Previous studies have suggested that pituitary tumor-transforming 3, pseudogene (PTTG3P), serves as an oncogene in human cancers. However, its expression pattern, biological function, and underlying mechanism in breast cancer remain unknown. In this study, we demonstrated an elevated expression of PTTG3P in breast cancer and discovered that PTTG3P expression correlated negatively with estrogen receptor (ER) and progesterone receptor (PR) status, but linked positively to basal-like status, triplenegative breast cancer status, Nottingham prognostic index (NPI), and Scarff-Bloom-Richardson grade. High expression of PTTG3P was also found to be associated with a poor prognosis of breast cancer. To explore the potential mechanisms of PTTG3P, a PTTG3P-microRNA (miRNA)-mRNA regulatory network was established. Co-expressed genes of PTTG3P were also obtained. Enrichment analysis for these co-expressed genes revealed that they were significantly enriched in mitotic nuclear division and cell cycle. Subsequent research on mechanism of PTTG3P indicated that its expression correlated positively with PTTG1 expression. However, no significant expression correlation between PTTG3P and PTTG2 was observed. Taken together, our findings suggest that increased expression of pseudogene PTTG3P may be used as a promising prognostic biomarker and novel therapeutic target for breast cancer.

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“…PTTG1-interacting protein (PTTG1IP), which is an oncogenic protein regulated the cell cycle with PTTG1. In thyroid cancer, PTTG1IP acted as a suppressor of p53 to affect the tumorigenesis [ 53 , 54 ]. According to the results of the betweenness and survival analysis in four disease types, LAMC2, GSN, and HIPK2 may respectively be the potential regulator in cell lines with grade 2 carcinoma, grade 3 carcinoma, and transitional cell carcinoma lymphatic metastasis.…”

Section: Discussionmentioning

confidence: 99%

Identification of GSN and LAMC2 as Key Prognostic Genes of Bladder Cancer by Integrated Bioinformatics Analysis

Yang

Wang

Cai

et al. 2020

Cancers

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Bladder cancer is a common malignancy with mechanisms of pathogenesis and progression. This study aimed to identify the prognostic hub genes, which are the central modulators to regulate the progression and proliferation in the specific subtype of bladder cancer. The identification of the candidate hub gene was performed by weighted gene co-expression network analysis to construct a free-scale gene co-expression network. The gene expression profile of GSE97768 from the Gene Expression Omnibus database was used. The association between prognosis and hub gene was evaluated by The Cancer Genome Atlas database. Four gene-expression modules were significantly related to bladder cancer disease: the red module (human adenocarcinoma lymph node metastasis), the darkturquioise module (grade 2 carcinoma), the lightgreen module (grade 3 carcinoma), and the royalblue module (transitional cell carcinoma lymphatic metastasis). Based on betweenness centrality and survival analysis, we identified laminin subunit gamma-2 (LAMC2) in the grade 2 carcinoma, gelsolin (GSN) in the grade 3 carcinoma, and homeodomain-interacting protein kinase 2 (HIPK2) in the transitional cell carcinoma lymphatic metastasis. Subsequently, the protein levels of LAMC2 and GSN were respectively down-regulated and up-regulated in tumor tissue with the Human Protein Atlas (HPA) database. Our results suggested that LAMC2 and GSN are the central modulators to transfer information in the specific subtype of the disease.

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PTTG1-interacting protein (PTTG1IP/PBF) predicts breast cancer survival

Cited by 26 publications

References 22 publications

High WDR34 mRNA expression as a potential prognostic biomarker in patients with breast cancer as determined by integrated bioinformatics analysis

High WDR34 mRNA expression as a potential prognostic biomarker in patients with breast cancer as determined by integrated bioinformatics analysis

High Expression of Pseudogene PTTG3P Indicates a Poor Prognosis in Human Breast Cancer

Identification of GSN and LAMC2 as Key Prognostic Genes of Bladder Cancer by Integrated Bioinformatics Analysis

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