Pubertal development in daughters of women with pre-eclampsia

Ogland, Bjorn; Nilsen, Stein Tore; Forman, Michéle R.; Vatten, Lars J.

doi:10.1136/adc.2009.178434

Cited by 23 publications

(36 citation statements)

References 14 publications

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“…In girls, the majority entered puberty by the 'thelarche pathway' or the 'synchronous pathway', and only 6.8% of the girls entered puberty by the 'pubarche pathway'. Our results were similar to data from Norway, where 8.4% (16/190) entered puberty by the pubarche pathway (29), whereas the prevalence of girls entering puberty by the pubarche pathway was 11.6% in a UK study and 14.5% in a US study (28,30). In a mixed population of black and white US girls, the prevalence was even higher (31).…”

Section: Pubertal Pathwayssupporting

confidence: 79%

“…Likewise, the percentage of girls entering puberty through the 'synchronous pathway' was lower (15.3%) in our study compared with the Norwegian study (26.3%) and the US studies (46.3 and 55.7% respectively). The difference might reflect the different study designs; one study (29) combining one clinical examination with a later completion of a self-assessment form and another study (28) being longitudinal with annual examinations. The differences could also reflect differences in body fat content between the Scandinavian and the US adolescents.…”

Section: Pubertal Pathwaysmentioning

confidence: 99%

See 1 more Smart Citation

The pubertal transition in 179 healthy Danish children: associations between pubarche, adrenarche, gonadarche, and body composition

Mouritsen

Aksglæde

Soerensen

et al. 2013

European Journal of Endocrinology

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Background: Pubertal onset is usually defined by breast development in girls and testicular growth in boys. Pubarche is defined as the attainment of pubic hair and is considered as a sign of pubertal transition. Pubarche is preceded by a gradual increase in production of adrenal androgens, DHEA and D4-androstenedione (Adione), a process termed adrenarche. Objective: To study the natural course of pubertal transition and the associations with adrenarche, body fat, and linear growth. Design and methods: A longitudinal study of 179 healthy children (89 girls) with higher socioeconomic background examined every 6 months for 5 years. Pubic hair stage, breast stage, genital stage, testicular volume (TV), height, weight, and four skinfolds were measured. Results: In girls, median age (25th and 75th percentiles) at thelarche (B2C) was 10.1 years (9.3-10.9). In boys, median age at attaining a TV O3 ml was 11.5 years (10.9-12.0). Median age at pubarche (PH2C) was 10.9 years (10.3-11.4) in girls and 11.6 years (10.8-12.4) in boys. Only 6.8% (4/59) of the girls and 24.6% (15/61) of the boys developed pubic hair as the first isolated sign of puberty. Serum DHEAS and Adione increased with age, although the increase in Adione was most pronounced in girls. No associations between early age at thelarche/testicular growth and increased body fat (BMI and sum of four skinfolds) were observed. Conclusion: Danish children rarely experience pubarche as the first sign of puberty. No associations between age at pubertal onset and body composition were found. Circulating levels of Adione, but not DHEAS, increased with the onset of puberty, although with large interindividual variability.

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Section: Pubertal Pathwayssupporting

confidence: 79%

Section: Pubertal Pathwaysmentioning

confidence: 99%

The pubertal transition in 179 healthy Danish children: associations between pubarche, adrenarche, gonadarche, and body composition

Mouritsen

Aksglæde

Soerensen

et al. 2013

European Journal of Endocrinology

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show abstract

“…This finding is consistent with reduced risk of breast cancer among offspring and is hypothesized to be an effect of in utero androgen exposure [23,29]. Our results suggest exclusive breastfeeding may also modify the relationship of PE exposure in utero with breast development at 10.8 years.…”

Section: Discussionsupporting

confidence: 90%

“…Of these, 194 pairs (119 NT, 75 PE) returned and provided data at 12.9 years. Anthropometrics were measured and Tanner breast stage was assessed using palpation by trained pediatric research nurses according to protocols described previously [23]. Tanner stage was recorded as 1-5 and nurses were blind to the PE status of the participating children.…”

Section: Data Collectionmentioning

confidence: 99%

In utero preeclampsia exposure, milk intake and pubertal development

Schraw¹,

Ogland

Dong³

et al. 2015

Reproductive Toxicology

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“…Ogland and colleagues1 report that pubic hair development is more likely to precede breast development in girls born from pre-eclamptic pregnancies compared to girls born from uneventful normotensive pregnancies 1. The study included follow-up examination at 11 years of age in 323 girls born from pre-eclamptic pregnancies (n=120) or normotensive pregnancies (n=203).…”

mentioning

confidence: 99%